A5037193251- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Bioinformatics and Genomic Networks
- Cardiovascular Disease and Adiposity
- Metabolomics and Mass Spectrometry Studies
- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Pancreatic function and diabetes
- Diet and metabolism studies
- Dietary Effects on Health
- Iron Metabolism and Disorders
- Caveolin-1 and cellular processes
- Obesity and Health Practices
- Galectins and Cancer Biology
- Machine Learning in Bioinformatics
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
- Nuts composition and effects
- Gut microbiota and health
- Cardiovascular Health and Disease Prevention
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
Uppsala University
2025
Lund University
2017-2024
Skåne University Hospital
2017-2023
Genomics (United Kingdom)
2022
University of Dundee
2022
Background Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with without type 2 diabetes (T2D). Early diagnosis of NAFLD important, as this can help prevent irreversible damage to the and, ultimately, hepatocellular carcinomas. We sought expand etiological understanding develop a diagnostic tool for using machine learning. Methods findings utilized baseline data from IMI DIRECT, multicenter prospective cohort study 3,029...
Abstract Obesity and type 2 diabetes are causally related, yet there is considerable heterogeneity in the consequences of both conditions mechanisms action poorly defined. Here we show a genetic-driven approach defining two obesity profiles that convey highly concordant discordant diabetogenic effects. We annotate then compare association signals for these across clinical molecular phenotypic layers. Key differences identified wide range traits, including cardiovascular mortality, fat...
<title>Abstract</title> Obesity is a significant risk factor for Type 2 diabetes (T2D), disease that affects about 10% of the global population. also heterogeneous condition, and molecular mechanisms linking it to T2D are not yet fully understood. The aim this study was elucidate causal pathways between obesity characterize their signatures using an innovative multi-omics approach, thereby highlighting why some, but all, obese individuals develop T2D. We identified 513 independent...
While a dose-response relationship between physical activity and risk of diabetes has been demonstrated, few studies have assessed the relative importance different measures on risk. The aim was to examine association self-reported type 2 in prospective cohort study.Out 26,615 adults (45-74 years, 60% women) population-based Swedish Malmö Diet Cancer Study cohort, 3791 cases were identified from registers during 17 years follow-up. Leisure-time (17 activities), occupational domestic through...
Abstract Leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins have been implicated as regulators of growth factor signaling; however, the possible redundancy among mammalian LRIG1, LRIG2, LRIG3 has hindered detailed elucidation their physiological functions. Here, we show that Lrig -null mouse embryonic fibroblasts (MEFs) are deficient in adipogenesis bone morphogenetic protein (BMP) signaling. In contrast, transforming factor-beta (TGF-β) receptor tyrosine kinase (RTK)...
Excess adiposity is differentially associated with increased risk of cardiometabolic disease in men and women, according to observational studies. Causal inference studies largely assume a linear relationship between BMI outcomes, which may not be the case. In this study, we investigated shapes causal relationships diseases factors. We further sex differences within framework.
The association between leisure-time physical activity and cardiovascular mortality has been previously studied, but few studies have focused on specific activities intensities.The different was investigated among 25,876 individuals without diabetes or disease from the population-based Malmö Diet Cancer Study cohort. estimated average duration spent 17 at baseline in 1991-1996 after 5 years. Cardiovascular obtained a register during mean of 20 years follow-up.A total 15-25 metabolic...
Background Diet and physical activity (PA) are modifiable risk factors thought to influence the of ischemic stroke (IS). However, few studies have examined their effect on different subtypes IS. Aim To examine components overall diet quality types PA in relation atherothrombotic IS (aIS). Materials methods The study population included 23,797 participants (mean age 58 years; 63% women) from Malmö Cancer Study cohort. Participants were enrolled between 1991 1996 followed until end 2016...
ABSTRACT Background Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in type 2 diabetes (T2D) beyond. Early diagnosis of NAFLD important, as this can help prevent irreversible damage to the ultimately hepatocellular carcinomas. Methods Findings Utilizing baseline data from IMI DIRECT participants (n=1514) we sought expand etiological understanding develop a diagnostic tool for using machine learning. Multi-omic (genetic, transcriptomic,...
Abstract Obesity and type 2 diabetes are causally related, yet the underlying mechanisms poorly defined. We aimed to subclassify obesity into etiological subtypes using a genetic-driven agnostic approach. Genetic instruments for body mass index were classified profiles that convey highly concordant (48 SNPs) discordant (19 diabetogenic effects. annotated association signals these across clinical molecular phenotypic layers, spanning > 5,000 traits. Using combination of machine-learning...
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20663-6