A5021704586- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- Nutritional Studies and Diet
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Bladder and Urothelial Cancer Treatments
- Diet and metabolism studies
- Glutathione Transferases and Polymorphisms
- Birth, Development, and Health
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- Multiple and Secondary Primary Cancers
- Alcohol Consumption and Health Effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Endometrial and Cervical Cancer Treatments
- Esophageal Cancer Research and Treatment
- Prostate Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Prostate Cancer Treatment and Research
- Cardiovascular Disease and Adiposity
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
Lund University
2016-2025
Malmö University
2016
Umeå University
2007-2015
Copenhagen University Hospital
2011-2014
Mid Yorkshire Hospitals NHS Trust
2012
King's College London
2012
Amsterdam Public Health
2011
Sahlgrenska University Hospital
2010
Norwegian Institute of Public Health
2010
Skåne University Hospital
2010
Observational studies have shown inconsistent results for the association between blood pressure and cancer risk. We investigated in 7 cohorts from Norway, Austria, Sweden. In total, 577799 adults with a mean age of 44 years were followed for, on average, 12 years. Incident cancers 22184 men 14744 women, deaths 8724 4525, respectively. Cox regression was used to calculate hazard ratios per 10-mmHg increments midblood pressure, which corresponded 0.7 SDs and, example, an increment...
The epidemiological evidence for an obesity-cancer association is solid, whereas the between obesity-associated lipoprotein levels and cancer less evident. We investigated circulating of Apolipoprotein A1 (ApoA1), B (ApoB), LDL-cholesterol (LDL-C) HDL-cholesterol (HDL-C) to risk overall common forms. Malmö Diet Cancer Study, a population-based prospective cohort study, enrolled 17,035 women 11,063 men (1991-1996). Incident cases were ascertained by record linkage with Swedish Registry until...
Background Prospective studies have indicated that elevated blood glucose levels may be linked with increased cancer risk, but the strength of association is unclear. We examined between and risk in a prospective study six European cohorts. Methods Findings The Metabolic syndrome Cancer project (Me-Can) includes cohorts from Norway, Austria, Sweden; current included 274,126 men 275,818 women. Mean age at baseline was 44.8 years mean follow-up time 10.4 years. Excluding first year follow-up,...
Few studies have assessed the metabolic syndrome (MetS) as an entity in relation to breast cancer risk, and results been inconsistent. We aimed examine association between MetS factors (individually combined) risk of incidence mortality.Two hundred ninety thousand women from Austria, Norway, Sweden were enrolled during 1974-2005, with measurements height, weight, blood pressure, levels glucose, cholesterol, triglycerides. Relative risks (RR) estimated using Cox proportional hazards...
Initial studies have indicated diabetes and obesity to be risk factors for hepatocellular carcinoma; but the association between other metabolic primary liver cancer (PLC) has not been investigated. The syndrome project (Me-Can) includes cohorts from Norway, Austria Sweden with data on 578,700 subjects. We used Cox proportional hazard models calculate relative risks (RRs) of PLC by body mass index (BMI), blood pressure plasma levels glucose, cholesterol triglycerides as continuous...
Background: There are few data on the joint influence of metabolic factors risk separate cancers. Methods: We analysed body mass index, blood pressure and plasma levels glucose, total cholesterol triglycerides from seven European cohorts comprising 564 596 men women with a mean age 44 years. weighted those equally into standardized score [MRS, = 0, standard deviation (SD) 1], an individual's level indicated as SDs sex- cohort-specific means. Cancer hazard ratios were calculated by Cox...
Objective To investigate the association between total serum cholesterol (TSC) and cancer incidence in Metabolic syndrome Cancer project (Me-Can). Methods Me-Can consists of seven cohorts from Norway, Austria, Sweden including 289,273 male 288,057 female participants prospectively followed up for (n = 38,978) with a mean follow-up 11.7 years. Cox regression models age as underlying time metric were used to estimate hazard ratios (HR) their 95% confidence intervals (CI) quintiles levels per 1...
Obesity is associated with an increased risk of esophageal adenocarcinoma (EAC) and a decreased squamous cell carcinoma (ESCC). However, little known about the EAC ESCC related to other metabolic factors. We aimed examine in relation factors, separately combined prospective cohort study.The Metabolic Syndrome Cancer includes cohorts Austria, Norway Sweden, blood pressure, lipids, glucose BMI available from 578 700 individuals. Relative (RR) for was calculated using Cox's proportional hazards...
The role of insulin resistance as a mediator in the association body mass index (BMI) with site-specific cancer risk has, to our knowledge, never been systematically quantified.Altogether 510 471 individuals from six European cohorts, mean age 43.1 years, were included. We used triglyceride glucose product (TyG index) surrogate measure for resistance. fitted Cox models, adjusted relevant confounders, investigate associations TyG 10 common obesity-related cancers, and quantified proportion...
Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association systolic (SBP) and diastolic (DBP) blood pressure development incident cancer at anatomical sites in European Prospective Investigation into Cancer Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) estimated using multivariable Cox proportional hazards models, stratified by EPIC‐participating center age recruitment, adjusted for sex,...
Studies of obesity with or without metabolic aberrations, commonly termed metabolically unhealthy healthy obesity, in relation to cancer risk are scarce.We investigated body mass index (normal weight, overweight, obesity) jointly and interaction health status obesity-related (n = 23 630) among 797 193 European individuals. A score comprising mid-blood pressure, plasma glucose, triglycerides was used define status. Hazard ratios (HRs) multiplicative interactions were assessed using Cox...
Obesity, assessed by body mass index (BMI), is an established risk factor for 13 cancers. We aimed to identify further potential obesity-related cancers and quantify their association with BMI relative that of
The authors examined the association between metabolic syndrome and risk of incident endometrial fatal uterine corpus cancer within a large prospective cohort study. Approximately 290,000 women from Austria, Norway, Sweden were enrolled during 1974–2005, with measurements height, weight, systolic diastolic blood pressure, circulating levels glucose, total cholesterol, triglycerides. Relative risks estimated using Cox proportional hazards regression. was assessed as composite z score,...
Abstract BACKGROUND: The metabolic syndrome (MetS) has been related to an increased risk of colorectal cancer, but the modest size previous studies precluded detailed characterization role individual MetS factors and their interaction on risk. METHODS: In Metabolic Syndrome Cancer Project (Me‐Can), data body mass index (BMI), blood pressure, levels glucose, cholesterol, triglycerides were available for 578,700 men women. mean age participants at baseline was 44 years, follow‐up 12 years....
Abstract Background: The aim of this study was to investigate the association between factors in metabolic syndrome (MetS; single and combined) risk pancreatic cancer. Methods: Metabolic Syndrome Cancer Project is a pooled cohort containing data on body mass index, blood pressure, levels glucose, cholesterol, triglycerides. During follow-up, 862 individuals were diagnosed with Cox proportional hazards analysis used calculate relative risks (RR) 95% confidence intervals using abovementioned...
Abstract BACKGROUND: There are inconsistent data regarding the association between metabolic factors, separately and combined, risk of prostate cancer death from cancer. METHODS: In Metabolic Syndrome Cancer Project (Me‐Can), on body mass index (BMI); blood pressure; levels glucose, cholesterol, triglycerides were collected for 289,866 men. Cox proportional hazard models used to calculate relative risks (RRs) by exposures in quintiles as well z scores (with a mean 0 standard deviation 1)...
Previous studies have shown that obesity and hypertension are associated with increased risk of renal cell carcinoma (RCC), but less is known about the association to other metabolic factors. In Metabolic Syndrome Cancer project (Me-Can) data on body mass index (BMI, kg/m2), blood pressure, circulating levels glucose, cholesterol, triglycerides were collected from 560,388 men women in cohorts Norway, Austria, Sweden. By use Cox proportional hazard models, ratios (HR) calculated for separate...
To assess the association between height and risk of cancer death.The metabolic syndrome project is a prospective pooled cohort study 585,928 participants from seven cohorts in Austria, Norway, Sweden. Hazard ratios (HRs) 95 % confidence intervals (CIs) for incidence death were estimated categories per 5-cm increment each site using Cox proportional hazards model.During mean follow-up 12.7 years (SD = 7.2), 38,862 diagnosed with 13,547 died cancer. Increased (per increment) was associated an...
Obesity is an established risk factor for several cancers. Adult weight gain has been associated with increased cancer risk, but studies on timing and duration of adult are relatively scarce. We examined the impact BMI (body mass index) changes over time, as well excess weight, obesity- non-obesity-related cancers.We pooled health data from six European cohorts included 221 274 individuals two or more height measurements during 1972-2014. Several measures were constructed. Cancer cases...
Prospective and detailed investigations of smoking prostate cancer (PCa) risk death are lacking.To investigate prediagnosis habit (status, intensity, duration, cessation) as a factor, on its own combined with body mass index (BMI), for PCa incidence death.We included 351448 men information from five Swedish cohorts.We used Cox regression to calculate hazard ratios (HRs) confidence intervals (CIs) (n = 24731) 4322).Smoking was associated lower any (HR 0.89, 95% CI 0.86-0.92), which most...
Importance Prostate cancer, a leading cause of cancer death among men, urgently requires new prevention strategies, which may involve targeting men with an underlying genetic susceptibility. Objective To explore differences in risk early prostate higher vs lower to inform efforts. Design, Setting, and Participants This cohort study used combined analysis genotyped without at inclusion lifestyle data 2 prospective studies Sweden the US, Malmö Diet Cancer Study (MDCS) Health Professionals...
Background: A large number of prospective studies have shown that overweight and diabetes are related to an increased risk many cancers, including colorectal cancer. In contrast, has been a decreased prostate cancer, fatal, but not incident, Data from on metabolic factors diabetes, the association with cancer risk, limited. Aim: The aim this thesis was study in relation (paper I III), II V), overall VI). Methods: Study designs were i) case-control studies, nested within Northern Sweden...