A5060663599- Treatment of Major Depression
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Medical Imaging Techniques and Applications
- Electroconvulsive Therapy Studies
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Nicotinic Acetylcholine Receptors Study
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Cardiac Arrhythmias and Treatments
- Garlic and Onion Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Tryptophan and brain disorders
- Genetic Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Optical Imaging and Spectroscopy Techniques
- Cardiac Imaging and Diagnostics
- Receptor Mechanisms and Signaling
- Pharmacological Effects of Natural Compounds
- Nerve injury and regeneration
Karolinska Institutet
2007-2020
Stockholm County Council
2017-2020
Stockholm Health Care Services
2017
Mitsubishi Group (Japan)
2014
Mitsubishi Tanabe Pharma Corporation
2014
Suzuki (Japan)
2014
Tohoku University
2014
Nippon Medical School
2009-2010
Tokyo Medical and Dental University
1998-2001
Chiba Rosai Hospital
2001
The human serotonin transporter (5-HTT) gene is one of the most extensively studied in psychiatry. A functional polymorphism promoter region 5-HTT (5-HTTLPR) has been associated with several psychiatric disorders as well anxiety-related personality traits. In search a mechanistic understanding implications 5-HTTLPR, influence this on regional 5-HT1A receptor density previously examined two positron emission tomography (PET) studies humans, yielding, however, contradictory results. present...
Article AbstractResults: There were no significant differences in D2 receptor binding between patients with MDD and controls. All 7 showed clinical improvements response to ECT treatment (P†‰<†‰.001). Significant changes binding, a mean of 25.2% reduction, found the right rostral anterior cingulate (AC) following
In our previous positron emission tomography (PET) study, we demonstrated that ECT decreased dopamine D2 receptor in major depressive disorder (MDD). Although many animal studies have focused on the effect of serotonergic neurotransmission, no human study has directly examined brain serotonin [5-hydroxytryptamine (5-HT)] 1A receptors (5-HT1ARs). Using PET with [11C]WAY 100635, aimed to evaluate 5-HT1ARs patients MDD. Nine underwent scans before and after a series 6–7 bilateral ECTs....
Background:Central substance P receptors, termed NK-1 have been considered as therapeutic targets in the development of drugs against diverse conditions, including emesis, overactive bladder, and depression.
Extrastriatal D2 dopamine receptors represent an important target of research into the pathophysiology and pharmacotherapy psychiatric disorders. The high affinity radioligand [11C]FLB 457 makes possible measurement low concentrations in extrastriatal regions using positron emission tomography (PET). aim this study was to assess test/retest variability reliability binding a reference tissue model. Eight healthy male subjects (aged 20-33 years) underwent two PET examinations. Radioactivity...
Abstract Recent studies of the brain using magnetic resonance imaging (MRI) have suggested progressive structural changes in schizophrenics. However, those were conducted over periods less than 5 years and thus lacked sufficient capacity to determine course nature this process. In study, MRI scans obtained 15 schizophrenics 12 controls at baseline after 4‐ 10‐year follow ups. Volumes lateral ventricles measured. Patients assessed by Brief Psychiatric Rating Scale (BPRS) same two time points:...
The opioid antagonist naltrexone has been shown to attenuate the subjective effects of amphetamine. However, mechanisms behind this modulatory effect are currently unknown. We hypothesized that would diminish striatal dopamine release induced by amphetamine, which is considered an important mechanism many its stimulant properties. used positron emission tomography and D2-receptor radioligand [11C]raclopride in healthy subjects study dopaminergic amphetamine injection after pretreatment with...
The aim of the study was to test: (i) if D2 /D3 binding in three functional subsections striatum is different patients with severe major depressive episodes than controls; and (ii) this difference normalized after electroconvulsive therapy (ECT).Nine inpatients were examined positron emission tomography (PET) radioligand [11 C]raclopride before an average 8.4 ECT sessions. Treatment response assessed using Montgomery-Åsberg Depression Rating Scale. Nine age- sex-matched controls twice PET...
Abstract: Neuroleptics can induce not only physical adverse effects but also mental that produce deficit status in thought, affect, cognition, and behavior. This condition is known as neuroleptic-induced syndrome (NIDS), which includes apathy, lack of initiative, anhedonia, indifference, blunted reduced insight into disease. Although this old concept now appears almost forgotten, neuroleptics, whether typical or atypical, make depression bipolar disorder resemble other more refractory...
C-WAY 100635 has been used widely in the PET research field to measure 5-HT1A receptors living human brain. Reference tissue model analysis, which cerebellum was as reference tissue, employed clinical studies. However, reported binding potentials varied greatly among reports. In this study, regions of interest (ROIs) for were determined five different approaches six healthy male volunteers, and effects on potential parametric images compared.First, ROIs cerebellar cortex decided based...
Evidence-based psychopharmacological algorithms for the treatment of patients with schizophrenia have been developed in many countries last decade. While it would be interest to consider a common algorithm based on international consensus, and information antipsychotics available each country are limited. Inspired by generated International Psychopharmacology Algorithm (IPA) Project, this has Japan Psychophamacology (JPA) Project. New antipsychotics, such as clozapine, olanzapine quetiapine,...
Functional neuroimaging techniques enable noninvasive measurements of cognitive functions in humans.We used functional to assess disturbance a patient with mild impairment.The was 58-year-old male memory disturbance, mini-mental state examination (MMSE) score 22! 30, and Clinical Dementia Rating Scale 0.5.On the Wechsler Adult Intelligence (WAIS-iii), intelligence quotient tests indicated total IQ=64, verbal IQ=71, performance IQ=61.The showed cortical atrophy on structural magnetic...