A5046405766- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Drug Transport and Resistance Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Statistical Methods in Clinical Trials
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Radiopharmaceutical Chemistry and Applications
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Angiogenesis and VEGF in Cancer
- Frailty in Older Adults
- Obsessive-Compulsive Spectrum Disorders
- Statistical Methods and Inference
- Trace Elements in Health
- Body Composition Measurement Techniques
- Migraine and Headache Studies
- Radiomics and Machine Learning in Medical Imaging
- Cerebrovascular and Carotid Artery Diseases
- Epilepsy research and treatment
Antaros Medical (Sweden)
2022-2025
Lund University
2016-2023
Copenhagen University Hospital
2018-2023
Rigshospitalet
2019-2022
Columbia University
2016-2020
New York State Psychiatric Institute
2018
New York Psychoanalytic Society and Institute
2018
Karolinska Institutet
2011-2017
Stockholm County Council
2017
Columbia University Irving Medical Center
2017
A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve the diagnosis, and ultimately treatment of α-synuclein-related diseases. Here we show that PET ligand, [
Progressive supranuclear palsy (PSP) is difficult to diagnose accurately. The recently developed tau PET tracers may improve the diagnostic work-up of PSP.Regional accumulation was studied using 18 F-AV-1451 in 11 patients with PSP and age-matched healthy controls Swedish BioFinder study.18 standard uptake volume ratios were significantly higher basal ganglia when compared (globus pallidus 1.75 vs 1.50; putamen 1.51 1.35). Retention correlated age both groups (r = .43-.78, P < .05). In PSP,...
It is a growing concern that outcomes of neuroimaging studies often cannot be replicated. To counteract this, the magnetic resonance (MR) community has promoted acquisition standards and created data sharing platforms, based on consensus how to organize share MR data. Here, we take similar approach positron emission tomography (PET) facilitate comparison findings across studies, first recommend publication for tracer characteristics, image acquisition, preprocessing, outcome estimation PET...
Aggregation of hyperphosphorylated tau is a major hallmark many neurodegenerative diseases, including Alzheimer disease (AD). In vivo imaging with PET may offer important insights into pathophysiologic mechanisms, diagnosis, and progression. We describe different strategies for quantification 18F-AV-1451 (T807) binding, models blood sampling noninvasive alternatives. Methods: Fifteen subjects (4 controls, 6 AD, 3 progressive supranuclear palsy, 2 cortico basal syndrome) underwent 180-min...
Developing positron emission tomography (PET) radioligands for the detection of endogenous serotonin release will enable investigation serotonergic deficits in many neuropsychiatric disorders. The present study investigates how acute challenges that aim to increase or decrease cerebral levels affect binding 2A receptor (5-HT2AR) agonist radioligand [11C]Cimbi-36. In a randomized, double-blind, placebo-controlled, three-arm design, 23 healthy volunteers were PET scanned twice with...
<h3>Importance</h3> Triptans, the most efficient acute treatment for migraine attacks, are 5-HT<sub>1B/1D</sub>receptor agonists, but their precise mechanism of action is not completely understood. The extent to which triptans enter central nervous system and bind 5-HT<sub>1B</sub>receptors in brain unknown. <h3>Objectives</h3> To determine occupancy sumatriptan 5-HT<sub>1B</sub>receptors, investigate changes serotonin levels during attacks. <h3>Design, Setting, Participants</h3> This study...
Changes in P-glycoprotein and ABCG2 densities may play a role amyloid-beta accumulation Alzheimer's disease. However, previous studies report conflicting results from different brain regions, without correcting for changes vessel density. We developed an automated method to measure transporter density exclusively within the vascular space, thereby then examined variability across matter, disease using two cohorts of post-mortem brains patients age-matched controls. were also investigated...
A metabolite corrected arterial input function is a prerequisite for quantification of positron emission tomography (PET) data by compartmental analysis. This quantitative approach also necessary radioligands without suitable reference regions in brain. The measurement laborious and requires cannulation peripheral artery, procedure that can be associated with patient discomfort potential adverse events. non invasive obtaining the thus preferable. In this study, we present novel method to...
<sup>18</sup>F-(E)-<i>N</i>-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β-(4′methylphenyl)nortropane (<sup>18</sup>F-FE-PE2I) is a newly developed dopamine transporter (DAT) PET radioligand. Full quantification methods rely on dynamic acquisition of <sup>18</sup>F-FE-PE2I, but in clinical setting simplified protocol preferable. The aims this study were to identify the optimal time window for <sup>18</sup>F-FE-PE2I and validate specific binding ratio (SBR) as method. <b>Methods:</b> Ten...