A5070831623- Mental Health Research Topics
- Digital Mental Health Interventions
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Personality Disorders and Psychopathology
- Psychotherapy Techniques and Applications
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Mental Health Treatment and Access
- Cerebral Palsy and Movement Disorders
- Psychosomatic Disorders and Their Treatments
- Sleep and related disorders
- Autism Spectrum Disorder Research
- Treatment of Major Depression
- Impact of Technology on Adolescents
- Resilience and Mental Health
- Gastrointestinal motility and disorders
- Healthcare professionals’ stress and burnout
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Grit, Self-Efficacy, and Motivation
- Sleep and Wakefulness Research
- Occupational Therapy Practice and Research
- Obsessive-Compulsive Spectrum Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Technology Adoption and User Behaviour
Stockholm Health Care Services
2018-2024
Karolinska Institutet
2013-2024
Karolinska University Hospital
2021-2022
Stockholm County Council
2018-2019
Linköping University
2019
St Göran's Children's Hospital
2008
Saint Göran Hospital
1998
It is unclear whether d-cycloserine (DCS), a partial N-methyl-d-aspartate agonist that enhances fear extinction, can augment the effects of exposure-based cognitive behavioral therapy (CBT) for obsessive-compulsive disorder (OCD).To examine DCS augments CBT OCD and to explore (post hoc) concomitant antidepressant medication moderates DCS.A 12-week, double-blind randomized clinical trial with 3-month follow-up conducted at an academic medical center between September 4, 2012, 26, 2013....
This study aimed to demonstrate proof of concept for an adaptive treatment strategy in Internet-delivered cognitive-behavioral therapy (ICBT), where risk failure is assessed early and at-risk patients adapted prevent failure.A semiautomated algorithm 251 undergoing ICBT insomnia with therapist guidance. At-risk were randomly assigned continue standard or receive ICBT. The primary outcome was self-rated symptoms using the Insomnia Severity Index a linear mixed-effects model. main secondary...
<b><i>Introduction:</i></b> Insomnia and depression are highly prevalent disorders commonly occur together. Cognitive behavioral therapy for insomnia, CBT-I, has been shown to be effective in treating insomnia also comorbid depression. However, it is unclear whether effects of CBT-I on specific or nonspecific. Also, depressive symptoms often remain too high after indicating a need improved treatments. The objective was determine combining with CBT depression, without...
Background: Internet-administered self-report measures of social anxiety, depressive symptoms, and sleep difficulties are widely used in clinical trials routine care, but data loss is a common problem that could render skewed estimates symptom levels treatment effects. One way reducing the negative impact missing be to use telephone administration as means complete from online collection. Objective: The aim study was compare convergence Internet difficulties. Methods: Liebowitz Social...
Although the effectiveness of therapist-guided internet-based cognitive behaviour therapy (ICBT) for treating depression has been well documented, knowledge outcome predictors and risk factors associated with lower treatment response is limited, especially when conducted within a naturalistic clinical setting. Identification such important clinicians making recommendations.Data from large cohort (N = 1738) adult outpatients having treated ICBT at an outpatient psychiatric clinic were...
Major depressive disorder is heritable and a leading cause of disability. Cognitive behavior therapy an effective treatment for major depression. By quantifying genetic risk scores based on common variants, the aim this report was to explore utility psychiatric cognitive trait scores, predicting response 894 adults with therapy. The participants were recruited in setting, primary outcome score measured using Montgomery Åsberg Depression Rating Scale-Self Rated. Single-nucleotide polymorphism...
Abstract Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood anxiety disorders. shortening counteracted by the enzyme telomerase protection also provided antioxidant glutathione peroxidase (GPx). Here, telomerase, GPx, were investigated 46 social disorder (SAD) patients within-subject design with repeated measures before after cognitive behavioral therapy. Treatment outcome was assessed Liebowitz Social Anxiety Scale (self-report), administered...
Previous studies have supported acceptance and commitment therapy (ACT) for reducing impairment related to various chronic conditions. ACT may possibly be beneficial bipolar disorder (BD) with co-existing anxiety, which is associated a poorer treatment outcome. Efforts are needed identify suitable psychological interventions BD anxiety. In this open clinical trial, we included 26 patients type 1 or 2 at an outpatient psychiatric unit specializing in affective disorders. The intervention...
The DSM‐IV section of the and ICD‐10 Personality Questionnaire (DIP‐Q) was used to screen for personality disorders in 448 subjects from three clinical samples (general forensic psychiatric patients candidates psychotherapy) a sample 139 healthy volunteers. Differences between with regard patterns pathology relation concurrent Axis I sociodemographic variables were analysed. prevalence according DIP‐Q 14% among volunteers, compared 59% general sample, 68% up 90% psychotherapy candidates....
The aim of this study was to evaluate the reliability and validity Swedish version self-rated 36-item WHODAS 2.0 in patients from psychiatric outpatient settings, using classical test theory.The 2.0, together with Sheehan Disability Scale (SDS), filled by a sample 780 participating patients: 512 (65.6%) women, 263 (33.7%) men, 5 (0.6%) who did not report any sex.The internal consistency, measured Cronbach's alpha, for different domains functioning were between 0.70 0.94, interpreted as good....
The 14-item Short Health Anxiety Inventory (SHAI-14) is a common measure of health anxiety but its screening properties have not been studied. aims this study were to evaluate the SHAI-14 as instrument, identify cut-offs for clinically significant and investigate which scores correspond different severity levels. included 1729 psychiatric patients 85 healthy controls. Participants completed underwent diagnostic interview. Cut-off evaluated in three scenarios approximate 1) clinic, 2) low...
The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is a generic instrument for the assessment of functioning in six domains, resulting total health-related disability score. aim this study was to investigate psychometric properties Swedish-language version self-rated 36-item psychiatric outpatients with various common diagnoses using Rasch analysis. A secondary explore correlation between two methods calculating overall scores guide clinical practice: WHODAS simple...
To minimize the burden in detecting and monitoring Panic Disorder Agoraphobia by developing a very brief scale with selected items from Severity Scale-Self Report (PDSS-SR), to investigate proposed scale's psychometric properties comorbid sample.A sample of 5103 patients Internet Psychiatry Clinic Sweden, diagnosed treated Internet-based cognitive behavioral therapy for panic disorder (n = 1390), social anxiety 1313) or depression 2400), responded PDSS-SR. Six criteria related factor...
Purpose Depression and anxiety afflict millions worldwide causing considerable disability. MULTI-PSYCH is a longitudinal cohort of genotyped phenotyped individuals with depression or disorders who have undergone highly structured internet-based cognitive-behaviour therapy (ICBT). The overarching purpose to improve risk stratification, outcome prediction secondary preventive interventions. precision medicine initiative that combines clinical, genetic nationwide register data. Participants...
A better understanding is needed of factors behind the long-term outcome dysthymic and panic disorders. Combining patients' perceptions that help hind remission with objective assessments may give greater insight into mechanisms for maintaining recovery. Twenty-three 15 disorder patients participated in a 9-year follow-up investigation naturalistic study psychotherapy antidepressants. Degree was determined by reassessments SCID-I & II interviews, self-reported symptoms life-charting (aided...
The highly prevalent psychiatric disorders dysthymia and panic disorder have often a chronic or recurrent course with superimposed major depression. prominent comorbidity between these diagnoses constitutes confounding factor in the study of long-term outcome. We performed 9-year follow-up 38 patients “pure” diagnoses, i.e. without comorbid disorder, selected from two 2-year naturalistic treatment studies psychotherapy antidepressant medication. aims present were to investigate 1) stability...
Disorder-specific internet treatment, based on cognitive-behavioral therapy, has been a part of routine psychiatric care in Sweden since 2007, provided at the Internet Psychiatry Clinic Stockholm. Individually tailored treatments, with opportunity to target more than one condition within same then evaluated randomized trials promising results. To introduce an individually treatment into clinical setting originally designed for disorder-specific processes creates challenges, such as how...
Internet-Based Cognitive Behavioral Therapy (iCBT) holds great potential in addressing mental health issues, yet its real-world implementation poses significant challenges. While prior research has predominantly focused on centralized care models, this study explores the of iCBT context decentralized organizational structures within Swedish primary setting, where all interventions traditionally are delivered at local Primary Care Centers (PCCs). This aims to enhance our understanding and...
Background Patients with irritable bowel syndrome (IBS) may benefit from psychological treatment when diet changes and medications do not sufficiently reduce symptoms. Our research team has developed an exposure based cognitive behavioral therapy protocol (ECBT), which been shown to be effective in several randomized controlled trials.Aim To investigate the effectiveness of ECBT clinical routine care at a gastroenterological clinic Stockholm find predictors for outcome.Method A ten session...
Abstract Background Irritable bowel syndrome (IBS) is a debilitating and costly disorder. Cognitive behavior therapy (CBT) effective in the treatment of IBS, both when delivered over internet face-to-face settings. CBT consists different components little known about their relative importance. We have an earlier study showed that inclusion exposure for IBS makes it even more effective. In present we wanted to evaluate economic effects society vs exclusion IBS. Methods used data from previous...
Irritable bowel syndrome (IBS) is a common and debilitating disorder. When dietary pharmacological interventions are not satisfactory, psychological treatment may produce good results. However, the access to such scarce, therefore, it of importance make use technical solutions. In this study, we wanted investigate real-world effectiveness an Internet-delivered exposure-based cognitive behavior therapy (ECBT) for IBS replicate earlier finding regarding working mechanism treatment.