A5002097553- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Obsessive-Compulsive Spectrum Disorders
- Psychedelics and Drug Studies
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Photoreceptor and optogenetics research
- Biochemical Analysis and Sensing Techniques
- Autism Spectrum Disorder Research
- Nicotinic Acetylcholine Receptors Study
- Functional Brain Connectivity Studies
- Cannabis and Cannabinoid Research
- Glioma Diagnosis and Treatment
- Eating Disorders and Behaviors
- Optical Imaging and Spectroscopy Techniques
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Laser Applications in Dentistry and Medicine
University of Southern Denmark
2022-2024
Odense University Hospital
2023-2024
Copenhagen University Hospital
2021
Rigshospitalet
2021
Rapamycin, an inhibitor of the mechanistic target rapamycin (mTOR), has shown promise as a neuroprotective compound in preclinical studies. Reduced brain glucose metabolism and loss synaptic density are key features Alzheimer's disease that can be measured vivo using positron emission tomography (PET) imaging, allowing for assessment treatment effects on function. Here, we used PET to investigate acute single-dose Long-Evans rats. In repeated measures design, quantified changes [18F]FDG...
Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain serotonin 5-HT2A receptors by N,N-dimethyltryptamine (DMT). To reduce first pass metabolism oral DMT, preparations additionally contain reversible monoamine oxidase A (MAO-A) inhibitors, namely β-carboline alkaloids such harmine. However, there is lacking biochemical evidence substantiate this pharmacokinetic potentiation DMT in via systemic MAO-A...
Parkinson's disease (PD) is caused by progressive neurodegeneration and characterised motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which has been hypothesised to lead non-motor symptoms such as depression. Individuals with PD have both lower synaptic density changes in neuronal metabolic function basal ganglia, measured using [11C]UCB-J [18F]FDG positron emission tomography (PET),...
Abstract The combination of neuroimaging and targeted neuromodulation is a crucial tool to gain deeper understanding neural networks at circuit level. Infrared neurostimulation (INS) promising optical modality that allows evoke neuronal activity with high spatial resolution without need for the introduction exogenous substances in brain. Here, we report use whole-brain functional [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) imaging during INS dorsal striatum, performed...
Abstract The combination of neuroimaging and targeted neuromodulation is a crucial tool to gain deeper understanding neural networks at circuit level. Infrared neurostimulation (INS) promising optical modality that allows evoke neuronal activity with high spatial resolution without need for the introduction exogenous substances in brain. Here, we report use whole-brain functional [ 18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) imaging during INS dorsal striatum, performed...
Serotonergic psychedelic drugs have shown promising benefits in trials for various neuropsychiatric disorders. While the acute effects of these psychedelics last only a few hours, positive therapeutic can persist long after single administration. produce their by activating serotonin 2A receptors, but they differ other pharmacological aspects. To guide safest and most effective treatment specific disorders, it is crucial to gain better understanding distinct long-term on living brain. Here...
Abstract Dorsal striatal dopamine transmission engages the cortico-striato-thalamo-cortical (CSTC) circuit, which is implicated in many neuropsychiatric diseases, including obsessive-compulsive disorder (OCD). Yet it unknown if dorsal hyperactivity cause or consequence of changes elsewhere CSTC circuit. Classical pharmacological and neurotoxic manipulations other brain circuits suffer from various drawbacks related to off-target effects adaptive changes. Chemogenetics, on hand, enables a...
Abstract Parkinson’s disease (PD) is caused by progressive neurodegeneration and characterised motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which has been hypothesised to lead non-motor symptoms such as depression. Individuals with PD have both lower synaptic density changes in neuronal metabolic function basal ganglia, measured using [ 11 C]UCB-J 18 F]FDG positron emission tomography (PET),...
RationaleThe psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are attributed to N,N-dimethyltryptamine (DMT) at brain serotonin 5-HT2A receptors. To make oral DMT bioavailable, additionally contains reversible monoamine oxidase A (MAO-A) inhibitors, namely β-carboline alkaloids such harmine. However, there is lacking biochemical evidence substantiate this pharmacokinetic potentiation in brain. ObjectivesTherefore, we measured profile harmine and rat...