A5029766452- Neurotransmitter Receptor Influence on Behavior
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Psychedelics and Drug Studies
- Receptor Mechanisms and Signaling
- Medical Imaging Techniques and Applications
- Chemical synthesis and alkaloids
- Pharmacological Receptor Mechanisms and Effects
- Drug Transport and Resistance Mechanisms
- Click Chemistry and Applications
- Parkinson's Disease Mechanisms and Treatments
- Nicotinic Acetylcholine Receptors Study
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Nanoparticle-Based Drug Delivery
- Obsessive-Compulsive Spectrum Disorders
- Amino Acid Enzymes and Metabolism
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
- Nanoplatforms for cancer theranostics
- Biochemical Analysis and Sensing Techniques
- Advanced Neuroimaging Techniques and Applications
- Neuropeptides and Animal Physiology
- Pharmacological Effects and Toxicity Studies
- Monoclonal and Polyclonal Antibodies Research
Odense University Hospital
2021-2024
University of Southern Denmark
2021-2024
Copenhagen University Hospital
2010-2024
Rigshospitalet
2008-2024
University of Copenhagen
2009-2024
Stanford University
2013-2016
Stanford Medicine
2014
Chonnam National University Hwasun Hospital
2011
Columbia University
2010
New York Psychoanalytic Society and Institute
2010
Species differences occur in the brain concentrations of drugs, but reasons for these are not yet apparent. This study was designed to compare uptake three radiolabeled P-glycoprotein (P-gp) substrates across species using positron emission tomography. Brain and brain-to-plasma ratios were compared; [<sup>11</sup>C]verapamil rats, guinea pigs, monkeys; [<sup>11</sup>C](<i>S</i>)-(2-methoxy-5-(5-trifluoromethyltetrazol-1-yl)-phenylmethylamino)-2(<i>S</i>)-phenylpiperidine (GR205171) monkeys,...
Materials with persistent luminescence are attractive for in vivo optical imaging since they have a long lifetime that allows the separation of excitation fluorophores and image acquisition time-delay imaging, thus eliminating tissue autofluorescence associated fluorescence imaging. Persistently luminescent nanoparticles previously been fabricated from toxic rare-earth metals. This work reports made conjugated polymer MEH-PPV can generate persisting an hour upon single excitation. A...
Drug Design: An (18)F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of (18)F apoptotic tumors is achieved through intramolecular macrocyclization situ aggregation upon activation (see picture).
Abstract Materials with persistent luminescence are attractive for in vivo optical imaging since they have a long lifetime that allows the separation of excitation fluorophores and image acquisition time‐delay imaging, thus eliminating tissue autofluorescence associated fluorescence imaging. Persistently luminescent nanoparticles previously been fabricated from toxic rare‐earth metals. This work reports made conjugated polymer MEH‐PPV can generate persisting an hour upon single excitation. A...
Early detection of tumor response to therapy is crucial the timely identification most efficacious treatments. We recently developed a novel apoptosis imaging tracer, <sup>18</sup>F-C-SNAT (C-SNAT caspase-sensitive nanoaggregation tracer), that undergoes an intramolecular cyclization reaction after cleavage by caspase-3/7, biomarker apoptosis. This caspase-3/7–dependent leads enhanced accumulation and retention <sup>18</sup>F activity in apoptotic tumors. study aimed fully examine vivo...
This detailed case report explores the application of ketamine-assisted psychotherapy (KAP) in treatment a 39-year-old male patient with Generalized Anxiety Disorder (GAD) and depressive symptoms. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine represents significant breakthrough mood anxiety disorders due to its rapid robust antidepressant effects. Preclinical studies demonstrate that promotes biological alterations brain, including enhancing neuroplasticity. However, no date...
IntroductionCognitive flexibility is essential for adapting behavior in response to environmental changes and implicated various neuropsychiatric disorders. Psilocybin, a serotonergic psychedelic, has shown potential enhancing cognitive flexibility, though results are mixed. This study investigates the effects of psilocybin on using three-choice visual reversal learning task rats.MethodsSixteen Long-Evans rats were trained touchscreen-based task. Following training initial testing, (COMP360,...
Rapamycin, an inhibitor of the mechanistic target rapamycin (mTOR), has shown promise as a neuroprotective compound in preclinical studies. Reduced brain glucose metabolism and loss synaptic density are key features Alzheimer's disease that can be measured vivo using positron emission tomography (PET) imaging, allowing for assessment treatment effects on function. Here, we used PET to investigate acute single-dose Long-Evans rats. In repeated measures design, quantified changes [18F]FDG...
Small-molecule α<sub>7</sub> nicotinic acetylcholine receptor (α<sub>7</sub>nAChR) agonists are currently validated for use as treatment cognitive disturbances in schizophrenia and Alzheimer disease. A suitable radiolabeled α<sub>7</sub>nAChR PET tracer would be important vivo quantification of binding humans to measure occupancy drug candidates. Here, we present the radiosynthesis evaluation <sup>11</sup>C-NS14492 a selective radioligand. <b>Methods:</b> The high-affinity...
Wirkstoff-Design: Ein 18F-markiertes Nanoaggregat-bildendes Capase-3-empfindliches Radiopharmakum für die Positronenemissionstomographie wurde hergestellt und Abbildung der Caspase-3-Aktivität in Doxorubizin-behandelten Tumorxenotransplantaten bewertet. Eine verstärkte Retention 18F-Aktivität apoptotischen Tumoren wird durch intramolekulare Makrocyclisierung In-situ-Aggregation nach Caspase-3-Aktivierung erhalten (siehe Bild).
Pretargeting is a powerful nuclear imaging strategy to achieve enhanced contrast for nanomedicines and reduce the radiation burden healthy tissue. based on bioorthogonal chemistry. The most attractive reaction this purpose currently tetrazine ligation, which occurs between trans-cyclooctene (TCO) tags tetrazines (Tzs). Pretargeted beyond blood-brain barrier (BBB) challenging has not been reported thus far. In study, we developed Tz agents that are capable of ligating in vivo targets BBB. We...
PET brain imaging of the serotonin 2A (5-hydroxytryptamine 2A, or 5-HT<sub>2A</sub>) receptor has been widely used in clinical studies, and currently, several well-validated radiolabeled antagonist tracers are for vivo cerebral 5-HT<sub>2A</sub> receptor. Access to agonist would, however, enable active, high-affinity state receptors, which may provide a more meaningful assessment membrane-bound receptors. In this study, we radiolabel...
Chemogenetic studies with the ligand clozapine N-oxide (CNO) are predicated upon assumption that CNO is devoid of actions at natural neuroreceptors. However, recent evidence shows may be converted back to (CLZ) in vivo, which could yield plasma concentrations sufficient occupy inter alia dopamine D2/3 and serotonin 5HT2A receptors living brain. To test this phenomenon, we measured striatal receptor occupancy [18F]fallypride PET ex vivo using [18F]MH.MZ. We found a dose-dependent effect on...
Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain serotonin 5-HT2A receptors by N,N-dimethyltryptamine (DMT). To reduce first pass metabolism oral DMT, preparations additionally contain reversible monoamine oxidase A (MAO-A) inhibitors, namely β-carboline alkaloids such harmine. However, there is lacking biochemical evidence substantiate this pharmacokinetic potentiation DMT in via systemic MAO-A...
Abstract The sharing of circulation between two animals using a surgical procedure known as parabiosis has created wealth information towards our understanding physiology, most recently in the neuroscience arena. systemic milieu is complex reservoir tissues, immune cells and circulating molecules that surprisingly not well understood terms its communication across organ systems. While model been used to probe physiological questions for many years, critical parameters recovery exchange...
Parkinson's disease (PD) is caused by progressive neurodegeneration and characterised motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which has been hypothesised to lead non-motor symptoms such as depression. Individuals with PD have both lower synaptic density changes in neuronal metabolic function basal ganglia, measured using [11C]UCB-J [18F]FDG positron emission tomography (PET),...
This study aims to further evaluate the specificity and selectivity of [18F]FTC-146 obtain additional data support its clinical translation. The binding [19F]FTC-146 vesicular acetylcholine transporter (VAChT) was evaluated using [3H]vesamicol PC12A123.7 cells in an vitro assay. uptake kinetics S1R-knockout mice (S1R-KO) compared wild-type (WT) littermates assessed dynamic positron emission tomography (PET) imaging. Ex vivo autoradiography histology were conducted a separate cohort S1R-KO/WT...