A5062030862- Hemoglobinopathies and Related Disorders
- Clinical Laboratory Practices and Quality Control
- Traumatic Brain Injury and Neurovascular Disturbances
- Iron Metabolism and Disorders
- Infrastructure Maintenance and Monitoring
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Traumatic Brain Injury Research
- Biomedical Text Mining and Ontologies
- LGBTQ Health, Identity, and Policy
- Blood transfusion and management
- Venous Thromboembolism Diagnosis and Management
- Structural Health Monitoring Techniques
- AI in cancer detection
- Platelet Disorders and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Chronic Lymphocytic Leukemia Research
- Microfluidic and Capillary Electrophoresis Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Single-cell and spatial transcriptomics
- Radiomics and Machine Learning in Medical Imaging
- Acute Myeloid Leukemia Research
- Blood groups and transfusion
- Prenatal Screening and Diagnostics
- Atrial Fibrillation Management and Outcomes
VA Palo Alto Health Care System
2014-2024
Palo Alto Veterans Institute for Research
2016-2024
The University of Texas Health Science Center at Houston
2012-2023
Global Blood Therapeutics (United States)
2021-2023
AbbVie (United States)
2023
Stanford University
2014-2022
ImmunityBio (United States)
2021
Saint Louis University
2021
Olive View-UCLA Medical Center
2020
Augusta University
2020
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, biocompatible near-infrared II fluorophore for in vivo imaging TBI designed. transient hypoperfusion the injured cerebral region, followed by leakage, observed. NIR-II fluorophores can provide noninvasive assessment TBI. As service to our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may be re-organized online...
Mild traumatic brain injury (mTBI, also referred to as concussion) accounts for the majority of all injuries. The consequences repetitive mTBI have become particular concern individuals engaged in certain sports or military operations. Many patients suffer long-lasting neurobehavioral impairments. In order expedite pre-clinical research and therapy development, there is a need animal models that reflect long-term cognitive pathological features seen patients. present study, we developed...
Chimeric antigen receptor (CAR) T-cell therapies are currently administered at a limited number of cancer centers and primarily delivered in an inpatient setting. However, variations total costs associated with these remain unknown.
Alzheimer disease (AD) represents a genetically heterogeneous entity. To elucidate neuropathologic features of autosomal dominant AD ([ADAD] due to PSEN1 , APP or PSEN2 mutations), we compared hallmark pathologic findings in 60 cases ADAD and 120 sporadic matched for sex, race, ethnicity, duration. Greater degrees neuritic plaque neurofibrillary tangle formation cerebral amyloid angiopathy (CAA) were found (p values < 0.01). Moderate severe CAA was more prevalent (63.3% vs. 39.2%, p =...
Feedback reduces opioid prescriptions Most people addicted to opioids began taking them because they were legally prescribed. Little attention has been paid changing physicians' prescribing behavior. Using a randomized controlled trial format, Doctor et al. monitored the effect of notifying physicians who had patient die overdose within 12 months prescription. The received an injunction prescribe safely from their county's medical examiner. This intervention led reductions in high-intensity...
Recent studies have shown promising results in using Deep Learning to detect malignancy whole slide imaging, however, they were limited just predicting a positive or negative finding for specific neoplasm. We attempted use with convolutional neural network (CNN) algorithm build lymphoma diagnostic model four categories: (1) benign lymph node, (2) diffuse large B-cell lymphoma, (3) Burkitt and (4) small lymphocytic lymphoma. Our software was written Python language. obtained digital...
Transforming growth factor-β (TGF-β) plays an important role in the development and maintenance of embryonic dopaminergic (DA) neurons midbrain. To study function TGF-β signaling adult nigrostriatal system, we generated transgenic mice with reduced mature neurons. These display age-related motor deficits degeneration system. Increasing substantia nigra through adeno-associated virus expressing a constitutively active type I receptor significantly reduces...
SignificanceNeurodegenerative diseases are poorly understood and difficult to treat. One common hallmark is lysosomal dysfunction leading the accumulation of aggregates other undegradable materials, which cause damage brain resident cells. Lysosomes acidic organelles responsible for breaking down biomolecules recycling their constitutive parts. In this work, we find that antiinflammatory neuroprotective compound, discovered via a phenotypic screen, imparts its beneficial effects by targeting...
What is known and objectives The two most common methods for monitoring unfractionated heparin (UFH) infusion are the activated partial thromboplastin time (aPTT) antifactor Xa assay (anti-Xa). purpose of this study to compare performance an aPTT protocol vs. anti-Xa in adult patients as defined by reach therapeutic range, percentage values were within goal range number times laboratory was conducted. We then analysed discordance between paired aPTT. Methods This a single-centre prospective...
Background Sickle cell disease (SCD) is a genetic that impacts patients' quality of life, healthcare costs, and life expectancy. Elevated sickle hemoglobin (HbS), which readily polymerizes, causes red blood sickling, leading to chronic hemolytic anemia complications often requiring hospitalization transfusions. In 2019, voxelotor, inhibits HbS polymerization, was approved for SCD treatment.Objectives This study uses real-world evidence assess voxelotor's effectiveness in patients typical...
The utility of bone marrow aspiration and biopsy (BMAB) as a diagnostic tool in patients with HIV/AIDS fever unknown origin (FUO) is subject debate. Because highly active antiretroviral therapy has reduced incidence opportunistic infections, it important to reassess the efficacy BMAB for this purpose. To our knowledge, no such studies have been performed Harris County which highest HIV state Texas.We reviewed all BMABs from FUO or persistent cytopenia(s) 2007 2011.Of 57 evaluable patients,...
Abstract The sharing of circulation between two animals using a surgical procedure known as parabiosis has created wealth information towards our understanding physiology, most recently in the neuroscience arena. systemic milieu is complex reservoir tissues, immune cells and circulating molecules that surprisingly not well understood terms its communication across organ systems. While model been used to probe physiological questions for many years, critical parameters recovery exchange...
Abstract Chimeric antigen receptor (CAR) T-cell therapies have demonstrated high response rates in patients with relapsed/refractory large B-cell lymphoma (LBCL); however, these are associated 2 CAR T cell–specific potentially severe adverse events (AEs): cytokine release syndrome (CRS) and neurological (NEs). This study estimated the management costs CRS/NEs among LBCL using data from pivotal TRANSCEND NHL 001 trial of lisocabtagene maraleucel, an investigational CD19-directed defined...
Patients who undergo cardiopulmonary bypass (CPB) are at risk for coagulopathy. Suboptimal turnaround time (TAT) of laboratory coagulation testing results in empiric administration blood products to treat massive bleeding. We describe our initiative establishing the coagulation-based hemotherapy (CBH) service, a clinical pathology consultation service that uses rapid TAT and provides comprehensive assessment bleeding patients undergoing CPB. A transfusion algorithm treats underlying cause...
ABSTRACT In response to the need for a safe, efficacious vaccine that elicits vigorous T cell as well humoral protection against SARS-CoV-2 infection, we have developed dual-antigen COVID-19 comprising both viral spike (S) protein modified increase cell-surface expression (S-Fusion) and nucleocapsid (N) with an Enhanced T-cell Stimulation Domain (N-ETSD) enhance MHC class I II presentation responses. The antigens are delivered using human adenovirus serotype 5 (hAd5) platform E1, E2b, E3...
*Harvard Medical School, Harvard University, Boston, MA †Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School Medicine ‡Division Health Sciences Informatics, §Department Policy Management, Bloomberg Public ∥Armstrong Institute for Patient Safety Quality, ¶Center Transgender Health, Medicine, Baltimore MD B.D.L.: is supported by the Excellence in Education Berkheimer Faculty Scholar Grant a contract (AD-1306-03980) from Patient-centered Outcomes Research...
Background Anal cancer is a rare malignancy that disproportionately affects men who have sex with (MSM) and HIV-infected people. associated human papillomavirus (HPV) in upward of 90% cases preceded by pre-cancerous changes cells the anal canal. High-resolution anoscopy (HRA) used for detection, treatment continued monitoring dysplasia. Practice guidelines regarding prevention vary jurisdiction institution, patient engagement low high-risk populations such as MSM. The purpose this study to...
Abstract Introduction Extended-release calcifediol (ERC), active vitamin D hormones and analogs (AVD) nutritional (NVD) are commonly used therapies for treating secondary hyperparathyroidism (SHPT) in adults with stage 3–4 chronic kidney disease (CKD) insufficiency (VDI). Their effectiveness increasing serum total 25-hydroxyvitamin (25D) reducing elevated plasma parathyroid hormone (PTH), the latter of which is associated increased morbidity mortality, has varied across controlled clinical...
Voxelotor is a first-in-class sickle hemoglobin-polymerization inhibitor that was approved in 2019 by the US Food and Drug Administration for treatment of patients with cell disease (SCD) aged ≥12 years; 2021, approval extended to children SCD 4 11 years. Additionally, both Ministry Health Prevention United Arab Emirates European Commission granted marketing authorization voxelotor September 2021 February 2022, respectively, adults pediatric Thus, additional information on patient experience...