A5003682246- Neuroinflammation and Neurodegeneration Mechanisms
- Behavioral and Psychological Studies
- Alzheimer's disease research and treatments
- Neurotransmitter Receptor Influence on Behavior
- Psychotherapy Techniques and Applications
- Neurology and Historical Studies
- Peripheral Artery Disease Management
- Neuroscience and Neuropharmacology Research
- Psychedelics and Drug Studies
- Diet and metabolism studies
Eli Lilly (United Kingdom)
2017
The choice and appropriate use of animal models in drug discovery for Alzheimer's disease (AD) is pivotal to successful clinical translation novel therapeutics, yet true alignment research challenging. Current do not fully recapitulate the human disease, even exhibit various degrees regional pathological burden diverse functional alterations. Given this, relevant endpoints must be determined on a model-by-model basis. present work explores rTg4510 mouse model tauopathy as case study define...
IntroductionCognitive flexibility is essential for adapting behavior in response to environmental changes and implicated various neuropsychiatric disorders. Psilocybin, a serotonergic psychedelic, has shown potential enhancing cognitive flexibility, though results are mixed. This study investigates the effects of psilocybin on using three-choice visual reversal learning task rats.MethodsSixteen Long-Evans rats were trained touchscreen-based task. Following training initial testing, (COMP360,...