A5026104657- Click Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Chemical Synthesis and Analysis
- Radiopharmaceutical Chemistry and Applications
- Synthetic Organic Chemistry Methods
- Crystallography and molecular interactions
- Solid-state spectroscopy and crystallography
- Advanced Chemical Physics Studies
TU Wien
2020-2024
Bioorthogonal chemistry is bridging the divide between static chemical connectivity and dynamic physiologic regulation of molecular state, enabling in situ transformations that drive multiple technologies. In spite maturing mechanistic understanding new bioorthogonal bond-cleavage reactions, broader goal ON/OFF control has been limited by inability existing systems to achieve both fast (i.e., seconds minutes, not hours) complete >99%) cleavage. To attain stringent performance characteristics...
Tetrazines (Tz) have been applied as bioorthogonal agents for various biomedical applications, including pretargeted imaging approaches. In radioimmunoimaging, pretargeting increases the target-to-background ratio while simultaneously reducing radiation burden. We recently reported a strategy to directly 18F-label highly reactive tetrazines based on 3-(3-fluorophenyl)-Tz core structure. Herein, we report kinetic study this versatile scaffold. A library of 40 different was prepared, fully...
Pretargeting is a powerful nuclear imaging strategy to achieve enhanced contrast for nanomedicines and reduce the radiation burden healthy tissue. based on bioorthogonal chemistry. The most attractive reaction this purpose currently tetrazine ligation, which occurs between trans-cyclooctene (TCO) tags tetrazines (Tzs). Pretargeted beyond blood-brain barrier (BBB) challenging has not been reported thus far. In study, we developed Tz agents that are capable of ligating in vivo targets BBB. We...
Abstract Halogen bonds are typically observed to have a linear arrangement with 180° angle between the nucleophile and halogen bond acceptor X−R. This linearity is commonly explained using σ‐hole model, although there been alternative explanations involving exchange repulsion forces. We employ two‐dimensional Distortion/Interaction Energy Decomposition Analysis examine archetypal H 3 N⋯X 2 systems. Our results indicate that predominantly electrostatic, their directionality largely due...
Tetrazines (Tz) have been applied as bioorthogonal agents for various biomedical applications including pretargeted imaging approaches. In radioimmunoimaging, pretargeting increases the target-to-background ratio while simultaneously reducing radiation burden. We recently reported a strategy to directly 18F-label highly reactive tetrazines based on 3-(3-fluorophenyl)-Tz core structure. Herein, we report kinetic study this versatile scaffold. A library of 40 different was prepared, fully...
Tetrazines (Tz) have been applied as bioorthogonal agents for various biomedical applications including pretargeted imaging approaches. In radioimmunoimaging, pretargeting increases the target-to-background ratio while simultaneously reducing radiation burden. We recently reported a strategy to directly 18F-label highly reactive tetrazines based on 3-(3-fluorophenyl)-Tz core structure. Herein, we report kinetic study this versatile scaffold. A library of 40 different was prepared, fully...