A5038823335- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Organic Chemistry Cycloaddition Reactions
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Mycotoxins in Agriculture and Food
- Radiopharmaceutical Chemistry and Applications
- X-ray Diffraction in Crystallography
- Synthesis and Catalytic Reactions
- Synthesis and Biological Evaluation
- Thyroid Cancer Diagnosis and Treatment
- Fungal Plant Pathogen Control
- Chemical Reactions and Isotopes
- Chemistry and Chemical Engineering
- Medical Imaging Techniques and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Asymmetric Synthesis and Catalysis
- Plant Disease Resistance and Genetics
- Molecular Junctions and Nanostructures
- Plant Pathogens and Fungal Diseases
TU Wien
2013-2025
Tumor targeting using agents with slow pharmacokinetics represents a major challenge in nuclear imaging and targeted radionuclide therapy as they most often result low contrast high radiation dose to healthy tissue. To address this challenge, we developed polymer-based agent that can be used for pretargeted thus separates tumor accumulation from the step time. The is based on polypeptide-graft-polypeptoid polymers (PeptoBrushes) functionalized trans-cyclooctene (TCO). complementary...
Bioorthogonal chemistry is bridging the divide between static chemical connectivity and dynamic physiologic regulation of molecular state, enabling in situ transformations that drive multiple technologies. In spite maturing mechanistic understanding new bioorthogonal bond-cleavage reactions, broader goal ON/OFF control has been limited by inability existing systems to achieve both fast (i.e., seconds minutes, not hours) complete >99%) cleavage. To attain stringent performance characteristics...
Bioorthogonal bond-cleavage reactions are powerful tools for investigating biological dynamics and advancing therapeutic strategies. Primed by click reactivity, the multi-step cascades that lead to bioorthogonal release have nevertheless been challenging navigate. For widely recognized tetrazine-triggered cleavage of trans-cyclooctenes (TCO), complexities post-click tautomerization key barrier achieving next-level molecular tools. Strategies anchor directing functionalities tetrazines (Tz)...
Bioorthogonal ligations have emerged as highly versatile chemical tools for biomedical research. The exceptionally fast reaction between 1,2,4,5-tetrazines and trans-cyclooctenes (TCOs), also known tetrazine ligation, is frequently used in this regard. Growing numbers of applications the ligation led to an increased demand TCO compounds, whose commercial availability still very limited. Reported photochemical procedures preparation TCOs using flow chemistry are straightforward high yielding...
We have investigated the inverse electron-demand Diels–Alder reactions of trans-cyclooctene (TCO) and endo-bicyclo[6.1.0]nonyne (BCN) with a 1,2,4,5-tetrazine, cyclopentadienone, an ortho-benzoquinone. Tetrazines react significantly faster TCO compared to BCN because highest occupied molecular orbital (HOMO) is higher in energy than HOMO there less distortion tetrazine. Despite different energies, similar reactivities toward cyclopentadienones, while more reactive cycloaddition find that...
Modified trans-cyclooctenes (TCO) are capable of highly efficient molecular manipulations in biological environments, driven by the bioorthogonal reaction with tetrazines (Tz). The development click-cleavable TCO has fueled field vivo chemistry and enabled design therapeutic strategies that have already started to enter clinic. A key element for most these approaches is implementation a cleavable linker. So far, only one member this class been developed, compound requires high synthetic...
Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, tetrazine-triggered elimination cleavable trans-cyclooctenes (click-to-release) stands out due to high reaction rates, versatility, and selectivity. Despite an increasing understanding underlying mechanisms, application this remains limited by cumulative performance trade-offs (i.e., click kinetics, release...
Bioorthogonal bond‐cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, tetrazine‐triggered elimination cleavable trans‐cyclooctenes (click‐to‐release) stands out due to high reaction rates, versatility, and selectivity. Despite an increasing understanding underlying mechanisms, application this remains limited by cumulative performance trade‐offs (i.e., click kinetics, release...
Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, tetrazine-triggered elimination cleavable trans-cyclooctenes (click-to-release) stands out due to high reaction rates, versatility, and selectivity. Despite an increasing understanding underlying mechanisms, application this remains limited by cumulative performance trade-offs (i.e., click kinetics, release...
Bond-cleavage reactions triggered by bioorthogonal tetrazine ligation have emerged as strategies to chemically control the function of (bio)molecules and achieve activation prodrugs in living systems. While most these approaches make use caged amines, current methods for release phenols are limited unfavorable reaction kinetics or insufficient stability Tz-responsive reactants. To address this issue, we implemented a self-immolative linker that enables connection cleavable trans-cyclooctenes...
Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, tetrazine-triggered elimination cleavable trans-cyclooctenes (click-to-release) stands out due to high reaction rates, versatility, and selectivity. Despite an increasing understanding underlying mechanisms, application this remains limited by cumulative performance trade-offs (i.e., click kinetics, release...
Bioorthogonal bond‐cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, tetrazine‐triggered elimination cleavable trans‐cyclooctenes (click‐to‐release) stands out due to high reaction rates, versatility, and selectivity. Despite an increasing understanding underlying mechanisms, application this remains limited by cumulative performance trade‐offs (i.e., click kinetics, release...
The title cyclobutane derivative, C 36 H 40 S 4 , formed serendipitously through a photochemically initiated [2 + 2] cycloaddition. asymmetric unit contains half molecule with the 2-(ethylsulfanyl)phenyl substituents in cis configuration, other of being generated by application twofold rotation operation. both halves molecules are trans arrangement relative to each other. ring shows angular and torsional strains, C—C—C bond angles 89.80 (8) 88.40 (8)°, an average absolute torsion angle 14.28...
Bond-cleavage reactions triggered by bioorthogonal tetrazine ligation have emerged as strategies to chemically control the function of (bio)molecules and achieve activation prodrugs in living systems. While most these approaches make use caged amines, current methods for release phenols are limited unfavorable reaction kinetics or insufficient stability Tz-responsive reactants. To address this issue, we implemented a self-immolative linker that enables connection cleavable trans-cyclooctenes...