A5030328260- Click Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- HER2/EGFR in Cancer Research
- Radiopharmaceutical Chemistry and Applications
- Synthesis and Biological Evaluation
TU Wien
2021-2025
A simple, scalable and reliable direct 18 F-labeling procedure has been developed applied to obtain a pretargeting tetrazine-based imaging agent with favorable in vivo characteristics.
Bioorthogonal bond-cleavage reactions are powerful tools for investigating biological dynamics and advancing therapeutic strategies. Primed by click reactivity, the multi-step cascades that lead to bioorthogonal release have nevertheless been challenging navigate. For widely recognized tetrazine-triggered cleavage of trans-cyclooctenes (TCO), complexities post-click tautomerization key barrier achieving next-level molecular tools. Strategies anchor directing functionalities tetrazines (Tz)...
Tetrazines (Tz) have been applied as bioorthogonal agents for various biomedical applications, including pretargeted imaging approaches. In radioimmunoimaging, pretargeting increases the target-to-background ratio while simultaneously reducing radiation burden. We recently reported a strategy to directly 18F-label highly reactive tetrazines based on 3-(3-fluorophenyl)-Tz core structure. Herein, we report kinetic study this versatile scaffold. A library of 40 different was prepared, fully...
Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, tetrazine-triggered elimination cleavable trans-cyclooctenes (click-to-release) stands out due to high reaction rates, versatility, and selectivity. Despite an increasing understanding underlying mechanisms, application this remains limited by cumulative performance trade-offs (i.e., click kinetics, release...
Bioorthogonal bond‐cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, tetrazine‐triggered elimination cleavable trans‐cyclooctenes (click‐to‐release) stands out due to high reaction rates, versatility, and selectivity. Despite an increasing understanding underlying mechanisms, application this remains limited by cumulative performance trade‐offs (i.e., click kinetics, release...
Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, tetrazine-triggered elimination cleavable trans-cyclooctenes (click-to-release) stands out due to high reaction rates, versatility, and selectivity. Despite an increasing understanding underlying mechanisms, application this remains limited by cumulative performance trade-offs (i.e., click kinetics, release...
Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, tetrazine-triggered elimination cleavable trans-cyclooctenes (click-to-release) stands out due to high reaction rates, versatility, and selectivity. Despite an increasing understanding underlying mechanisms, application this remains limited by cumulative performance trade-offs (i.e., click kinetics, release...
Bioorthogonal bond‐cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context. Among these chemistries, tetrazine‐triggered elimination cleavable trans‐cyclooctenes (click‐to‐release) stands out due to high reaction rates, versatility, and selectivity. Despite an increasing understanding underlying mechanisms, application this remains limited by cumulative performance trade‐offs (i.e., click kinetics, release...
Tetrazines (Tz) have been applied as bioorthogonal agents for various biomedical applications including pretargeted imaging approaches. In radioimmunoimaging, pretargeting increases the target-to-background ratio while simultaneously reducing radiation burden. We recently reported a strategy to directly 18F-label highly reactive tetrazines based on 3-(3-fluorophenyl)-Tz core structure. Herein, we report kinetic study this versatile scaffold. A library of 40 different was prepared, fully...
Pretargeted bioorthogonal imaging can be used to visualize and quantify slow accumulating targeting vectors with short-lived radionuclides such as fluorine-18 - the most clinically applied Positron Emission Tomography (PET) radionuclide. Pretargeting results in higher target-to-background ratios compared conventional approaches using long-lived radionuclides. Currently, tetrazine ligation is popular reaction for pretargeted imaging, but a direct18 F-labeling strategy highly reactive...
Tetrazines (Tz) have been applied as bioorthogonal agents for various biomedical applications including pretargeted imaging approaches. In radioimmunoimaging, pretargeting increases the target-to-background ratio while simultaneously reducing radiation burden. We recently reported a strategy to directly 18F-label highly reactive tetrazines based on 3-(3-fluorophenyl)-Tz core structure. Herein, we report kinetic study this versatile scaffold. A library of 40 different was prepared, fully...