A5004541632- Radiopharmaceutical Chemistry and Applications
- Atomic and Molecular Physics
- Medical Imaging Techniques and Applications
- Advanced Chemical Physics Studies
- Nuclear physics research studies
- Cold Atom Physics and Bose-Einstein Condensates
- Radioactive element chemistry and processing
- Pancreatic and Hepatic Oncology Research
- Medical Imaging and Analysis
- Nanoparticle-Based Drug Delivery
- Nanocluster Synthesis and Applications
- Advanced Semiconductor Detectors and Materials
- Peptidase Inhibition and Analysis
- Neutrino Physics Research
- Atomic and Subatomic Physics Research
- Medical Imaging and Pathology Studies
- Advanced Antenna and Metasurface Technologies
- Click Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Chemical Synthesis and Analysis
- Advanced NMR Techniques and Applications
- Crystallization and Solubility Studies
- Chemical Synthesis and Characterization
- Lung Cancer Treatments and Mutations
TU Wien
2016-2024
St Thomas' Hospital
2024
King's College London
2023-2024
We present a measurement of the low-energy (0–60 keV) γ-ray spectrum produced in α decay U233 using dedicated cryogenic magnetic microcalorimeter. The energy resolution ∼10 eV, together with exceptional gain linearity, allows us to determine low-lying isomeric state Th229 four complementary evaluation schemes. most precise scheme determines isomer be 8.10(17) corresponding 153.1(32) nm, superseding precision previous values based on γ spectroscopy, and agreeing recent internal conversion...
Abstract We have grown $$^{232}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mrow/> <mml:mn>232</mml:mn> </mml:msup> </mml:math> Th:CaF $$_2$$ <mml:msub> <mml:mn>2</mml:mn> </mml:msub> and $$^{229}$$ <mml:mn>229</mml:mn> single crystals for investigations on the VUV laser-accessible first nuclear excited state of Th, with aim building a solid-state clock. To reach high doping concentrations despite extreme scarcity (and radioactivity) we scaled down crystal...
Manganese dioxide (MnO2)-based nanostructures have emerged as promising tumour microenvironment (TME) responsive platforms. Herein, we used a one-pot reaction to prepare MnO2 with Pt(IV) prodrugs redox- (and thus TME-) theranostics for cancer therapy, in which the complexes act of cisplatin (Pt(II)), clinical chemotherapeutic drug. The cytotoxicity these MnO2-Pt(IV) probes was evaluated two and three dimensional (2D 3D) A549 cell models found be effective active drug 3D models. Moreover,...
Bioorthogonal ligations have emerged as highly versatile chemical tools for biomedical research. The exceptionally fast reaction between 1,2,4,5-tetrazines and trans-cyclooctenes (TCOs), also known tetrazine ligation, is frequently used in this regard. Growing numbers of applications the ligation led to an increased demand TCO compounds, whose commercial availability still very limited. Reported photochemical procedures preparation TCOs using flow chemistry are straightforward high yielding...
Natural-abundance phosphomolybdic acid (H
The first excited isomeric state of Th-229 has an exceptionally low energy only a few eV and could form the gateway to high-precision laser spectroscopy nuclei. excitation been inferred from precision $\ensuremath{\gamma}$ spectroscopy, but its uncertainty is still too large commence spectroscopy. Reducing this one most pressing challenges in field. Here we present approach infer isomer electron which emitted when de-excites through internal conversion (IC). experiment builds on U-233,...
Radiotheranostics are designed by labeling targeting (bio)molecules with radionuclides for diagnostic or therapeutic application. Because the pharmacokinetics of compounds play a pivotal role, chemically closely related imaging agents used to evaluate overall feasibility approach. "Theranostic relatives" that utilize different elements frequently in clinical practice. However, variations pharmacokinetics, biodistribution, and target affinity due chemical properties radioisotopes remain as...
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Abstract Neutron irradiation of gold foils in H 2 O causes the release 198 Au into liquid measurable quantities. Experiments prove that water indeed yields 10 times more activity than when foil is removed from before irradiation. The shows no correlation with yield ejected ions, but duration neutron does. However, not all experiments are fully conclusive as linearity between and emitted apparent. A speciation experiment by crystallization reveals nuclear reaction produces 3+ ions quantitatively.
We report here the improved synthesis of tripodal picolinate chelator Tpaa, with an overall yield 41% over five steps, in comparison to previously reported 6% yield. Tpaa was investigated for its coordination chemistry Ga(III) and radiolabeling properties gallium-68 (68Ga). The obtained crystal structure [Ga(Tpaa)] shows that three arms coordinate ion, fully occupying octahedral geometry. This is supported by 1H NMR which are symmetrical when coordinated Ga(III). Assessment thermodynamic...
We have grown $^{232}$Th:CaF$_2$ and $^{229}$Th:CaF$_2$ single crystals for investigations on the VUV laser-accessible first nuclear excited state of $^{229}$Th. To reach high doping concentrations despite extreme scarcity (and radioactivity) $^{229}$Th, we scaled down crystal volume by a factor 100 compared to established commercial or scientific growth processes. use vertical gradient freeze method 3.2 mm diameter seed with 2 drilled pocket, filled co-precipitated CaF$_2$:ThF$_4$:PbF$_2$...