A5101465191- Inflammasome and immune disorders
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Immune Cell Function and Interaction
- 3D Printing in Biomedical Research
- Pancreatic function and diabetes
- Insect Resistance and Genetics
- Hydrogels: synthesis, properties, applications
- Invertebrate Immune Response Mechanisms
- interferon and immune responses
- Schizophrenia research and treatment
- Atomic and Subatomic Physics Research
- Microfluidic and Capillary Electrophoresis Applications
- Treatment of Major Depression
- Cholinesterase and Neurodegenerative Diseases
- Insect Utilization and Effects
- Personality Disorders and Psychopathology
- Plant Pathogens and Fungal Diseases
- Epilepsy research and treatment
- IL-33, ST2, and ILC Pathways
- Obsessive-Compulsive Spectrum Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adenosine and Purinergic Signaling
- IgG4-Related and Inflammatory Diseases
- Plant Pathogens and Resistance
Kanagawa Dental University
2023
Duke University
2003-2016
Duke Medical Center
2000-2015
Duke University Hospital
2012-2015
The Nakamura Hajime Eastern Institute
2015
Nara Medical University
2000-2014
Karolinska Institutet
2009
Japan Science and Technology Agency
2001-2002
University of Miyazaki
2002
Tottori University
1988
In situ photopolymerization is an exciting new technique for tissue engineering. Two photocrosslinkable polysaccharides composed of alginate and hyaluronan are described that upon photolysis form soft, flexible, viscoelastic hydrogels. The degree methacrylate modification thus covalent affects mechanical properties such as swelling, compression, creep compliance. Significant swelling observed in aqueous solution; these hydrogels can swell up to 14 times their dry weight. Both exhibit low...
The NLRP3 inflammasome is a multiprotein complex consisting of three kinds proteins, NLRP3, ASC, and pro-caspase-1, plays role in sensing pathogens danger signals the innate immune system. thought to be involved development experimental autoimmune encephalomyelitis (EAE), an animal model multiple sclerosis (MS). However, mechanism by which induces EAE not clear. In this study, we found that played critical inducing T-helper cell migration into CNS. To gain migratory ability, CD4 + T cells...
Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently most fully characterized known to a wide array of microbes endogenous damage-associated molecules. Possible involvement (or inflammasomes) development multiple sclerosis (MS) was suggested number studies. Recent studies showed exacerbates experimental autoimmune encephalomyelitis (EAE), an animal model MS, although EAE can also develop without...
Summary Calcineurin plays essential roles in virulence and growth of pathogenic fungi is a target the natural products FK 506 C yclosporine A . In mucoralean fungus M ucor circinelloides , calcineurin mutation or inhibition confers yeast‐locked phenotype indicating that governs dimorphic transition. Genetic analysis this study reveals two catalytic subunits (out three) are functionally diverged. Homology modeling illustrates modes resistance resulting from amino substitutions interface...
Significance Appropriate development of inflammation is essential to protect hosts from microbial infections, but can occasionally overshoot and cause collateral damage in hosts. Such hyperinflammation happens during endotoxemia sepsis, attributed excessive production proinflammatory cytokines by host cells, such as macrophages. In this study, we demonstrate an unconventional mechanism which T cells regulate cytokine It our general understanding that fast-acting immune (such macrophages)...
Abstract We found that absence of osteopontin (OPN) in immunocompromised Rag2−/− mice, which lack T and B cells, made the mice extremely susceptible to an opportunistic fungus Pneumocystis, although immunocompetent OPN-deficient could clear Pneumocystis as well wild-type mice. OPN has been studied extracellular protein, role intracellular isoform (iOPN) is still largely unknown. In this study, we elucidated mechanism by iOPN was involved antifungal innate immunity. First, essential for...
Abstract An effective immune response to Ag challenge is critically dependent on the size of effector cell population generated from clonal activation Ag-specific T cells. The transcription network involved in regulating population, particularly for CD4 Th cells, poorly understood. In this study, we investigate role Id2, an inhibitor E protein factors, generation effectors. Using a cell-specific conditional Id2 knockout mouse model, show that DNA binding (Id)2 essential development...
Childhood- and adolescence-onset schizophrenic patients with obsessive-compulsive symptoms (OCS) constitute a specific subgroup of schizophrenia. We performed magnetic resonance imaging in this group seeking evidence neurodevelopmental insults.Thirty-two were compared 19 controls. Schizophrenic subjects divided into 15 OCS (SOCS+ group; onset at 15.5 +/- 1.6 years) 17 without (SOCS- 15.3 1.3 years). Areas the hippocampus, frontal lobe, corpus callosum putamen analysed morphometrically.The...
The following co-authors, Daijiro Miki, Anne Pfister-Serres, Kourosh Dastgheib, Makoto Inoue, and Diane L. Hatchell, were omitted from the original published article. A corrected page listing all authors appears opposite.
The injection of live or heat-killed bacteria into larvae trie silkworm, Bombyx mori, induced antibacterial activity in the hemolymph. A wide variety gram-negative and gram-positive were effective as inducing agents, but saline alone, yeast cells fungal spores not effective. activities separated six bands on native polyacrylamide gel electrophoresis, which sensitive to trypsin. Some these proteins partially purified by CM-cellulose column chromatography. heat-stable showed no lysozyme...
The purpose of this study was to determine whether the subretinal space would provide immune privilege for pancreatic islet transplantation. Islets from outbred Sprague Dawley (SD) rats were isolated by collagenase digestion, and about 200 handpicked islets transplanted into SD rats. Similar grafts subconjunctival as controls. Transplanted eyes enucleated after 2 60 days, fixed embedded in paraffin immunoperoxidase staining insulin, glucagon, CD8+ lymphocytes. Clinical examination rat...
The purpose of this study was to examine the biological response a hydroxyapatite (HA)/titanium dioxide (TiO2) hybrid (Hyb) coated implant surface after ultraviolet UV irradiation. After acid etching, titanium (Ti) disc and surfaces were modified using HA TiO2 targets, employing single-target dual-target sputter deposition techniques, subjected (UV) roughness hydrophilicity analyzed, biomechanical strength bone-implant interface assessed an push-in test. We found that irradiation improved...
Survival of pancreatic islet cells transplanted into the subretinal space in rat eyes was studied relation with apoptosis infiltrating lymphocytes. Islets isolated from inbred DA rats were fully MHC-mismatched Lewis rats. Syngeneic transplants and allogeneic Sprague-Dawley (SD) performed as controls. From 7 to 60 days after transplantation, immunoperoxidase staining for insulin, glucagon, CD4, CD8, interleukin (IL)-2, evaluation using nick-end labeling (TUNEL) performed. Fully grafts...
Interspecific somatic hybrids were obtained by electric protoplast fusion of cotyledon protoplasts Lycopersicon esculentum Mill. cv. Kyoryokutoko treated with iodoacetamide (IOA) and suspension-culture-derived L. chmielewskii (LA1330). A multiple-step selection procedure was used in selecting the depending on IOA treatments a culture medium that only allows to regenerate. Plants regenerated calli derived from fused protoplasts. After acclimation, hybrid plants fruits through self-pollination...