A5046422563- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Cerebral Palsy and Movement Disorders
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Traumatic Brain Injury Research
- Parkinson's Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Diet and metabolism studies
- Bipolar Disorder and Treatment
- Electrolyte and hormonal disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutrition, Genetics, and Disease
- Ion Transport and Channel Regulation
- Genetic Associations and Epidemiology
- Pelvic floor disorders treatments
- Estrogen and related hormone effects
- Cerebrovascular and Carotid Artery Diseases
- Neurological and metabolic disorders
- Prion Diseases and Protein Misfolding
- Neurological disorders and treatments
- Attention Deficit Hyperactivity Disorder
- Electroconvulsive Therapy Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurogenesis and neuroplasticity mechanisms
Nara Medical University
2010-2023
Nara Medical University Hospital
2009-2023
Sakai Municipal Hospital
2014
Japanese Society of Clinical Neuropsychopharmacology
2006
Tract-based analysis can be used to investigate required tracts extracted from other fiber tracts. However, the fractional anisotropy (FA) threshold influences tractography analysis. The current study evaluated influence of FA in measuring diffusion tensor parameters for tract-based uncinate fasciculus subjects with Alzheimer disease (AD).Subjects included 30 patients AD and 10 healthy controls. We acquired tractographies by using different thresholds. measured mean apparent coefficient...
Objective Metabolic syndrome contains many risks for medical diseases such as cardiovascular disease and diabetes, which might precipitate depressive symptoms in the older people. However, association between metabolic Japanese community‐dwelling people is unclear. This study was performed to answer this important question. Methods Cross‐sectional analyses were on 3796 independent (≥65 years, 1911 men 1885 women) from 2007–2008 baseline examination of Fujiwara‐kyo study, a prospective cohort...
Subjective cognitive impairment may be a very early at-risk period of the continuum dementia. However, it is difficult to discriminate states from normal aging. Thus, detection pathological changes in subjective needed. To elucidate these changes, we employed diffusion tensor imaging and volumetry analysis, compared with normal, mild Alzheimer's disease. The subjects this study were 39 disease, 43 impairment, 28 41 controls. There no statistically significant differences between control...
It is difficult to distinguish between bipolar disorder and major depressive (MDD) in patients lacking a clear history of mania. There an urgent need for objective biomarker differential diagnosis. Using diffusion tensor imaging, this study investigated the differences brain white matter microstructure with MDD.Participants included 16 23 MDD having depressed or euthymic states based on DSM-IV-TR criteria healthy volunteers. Whole-brain voxel-based morphometric analysis was used detect any...
Neuroimaging studies show increased diffusivity and decreased anisotropy in Alzheimer's disease (AD) patients by diffusion tensor imaging (DTI). Previous reports have analyzed a correlation with cognitive function DTI parameters, but their results are inconsistent. A reason for this might be region of interest (ROI) method, used to calculate parameters DTI, because method has various usages how place ROI includes summations values neuronal fiber tracts, resulting contamination unintended...
Objective A few studies have been performed on chronic structural changes after stroke. The primary purpose of the present study was to investigate regional cortical volume onset stroke and examine how affected neuropsychiatric symptoms. Methods Participants were 20 patients 14 control subjects. T1‐MRI twice, once at subacute stage again 6 months later, whole brain voxel‐based morphometric (VBM) analysis used detect significant gray matter in patients. We also assessed correlation between...
Polydipsia frequently occurs in schizophrenia patients. The excessive water loading polydipsia occasionally induces a hyponatremic state and leads to intoxication. Whether schizophrenic patients correlates with neuropsychological impairments or structural brain changes is not clear remains controversial.Eight polydipsic patients, eight nonpolydipsic healthy controls were recruited. All subjects underwent magnetic resonance imaging (MRI) testing. Structural abnormalities analyzed using...
Hemispherical asymmetry, sex differences and age-related changes have been reported for the human brain. Meanwhile it was still unclear presence of asymmetry or in brain occurred whether as a normal development consequences any pathological changes. The aim this study to investigate hemispherical by using tract-based analysis nerve bundles. 40 healthy elderly subjects underwent magnetic resonance diffusion tensor imaging, we calculated fractional anisotropy (FA) apparent coefficient (ADC)...
Abstract Background When the relationship between ageing and changes in personality traits is considered, it important to know how they are influenced by biological environmental factors. The present study examined relationships various factors associated with effect of on traits, including structural brain such as education. Methods We recruited 41 healthy subjects. administered NEO Five‐Factor Inventory assess Magnetic resonance imaging was performed, regional grey matter ( GM ) volumes...
Objective Caregivers of patients with dementia experience physical and mental deterioration. We have previously reported a correlation between caregiver burden the Frontal Assessment Battery (FAB) total scores Alzheimer's disease (AD), especially regarding dependency factor from Zarit Burden Interview. The present study aimed to identify an objective biomarker for predicting burden. Methods participants were 26 pairs caregivers AD mild‐to‐moderate dementia. Correlations regional gray matter...
The purpose of the current study was to assess feasibility diffusion tensor imaging (DTI) parameters for determining prognosis Alzheimer's disease (AD). We also analyzed correlation among DTI, voxel-based morphometry (VBM), and results mini-mental state examination (MMSE). subjects this prospective were patients with AD mild cognitive impairment. performed annual follow-ups VBM, MMSE 2 or 3 years. On apparent coefficient (ADC) fractional anisotropy (FA) uncinate fascicles measured. VBM...
Alzheimer's disease (AD) is associated with impairments in not only memory but also visuospatial cognitive function. Despite its adverse effects on the quality of life, patients early-stage AD are often neglected. Emerging evidence suggests that exhibit increased vulnerability myelin, a crucial component for neuronal conduction and survival. To test our hypothesis myelin damage was deficits AD, we examined correlations integrity, quantified by T1-weighted/T2-weighted (T1w/T2w) ratios,...
Abstract The present paper reports on a 68‐year‐old man with 10‐year history of parkinsonism who developed hallucinations and delusions after admission to an intensive care unit for the treatment organophosphate intoxication. His initial diagnosis was delirium. On basis brain computed tomography findings clinical symptoms, we diagnosed drug‐induced psychosis in multiple cysts bilateral striata.
A 55-year-old man with schizophrenia developed water intoxication due to primary polydipsia. His manner of antidiuretic hormone secretion was investigated by loading and infusion hypertonic saline clarify the form syndrome inappropriate secretion. The plasma level, which may be involved in occurrence intoxication, consistently low this patient, linked type D secretion, designated "hypovasopressinemic antidiuresis". Although is not common, it should considered as a pathophysiology for patients.