A5041032357- Attention Deficit Hyperactivity Disorder
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Heart Rate Variability and Autonomic Control
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Optical Imaging and Spectroscopy Techniques
- Neural and Behavioral Psychology Studies
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Music Perception
- Child and Adolescent Psychosocial and Emotional Development
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Nerve injury and regeneration
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Perfectionism, Procrastination, Anxiety Studies
- Memory and Neural Mechanisms
Nara Medical University
2016-2025
Icahn School of Medicine at Mount Sinai
2019-2021
Child Health and Development Institute
2019-2021
Allen Institute for Brain Science
2019-2021
Nara Medical University Hospital
2018
Microglia, the brain resident macrophages, critically shape forebrain neuronal circuits. However, their precise function in cerebellum is unknown. Here we show that human and mouse cerebellar microglia express a unique molecular program distinct from microglia. Cerebellar microglial identity was driven by CSF-1R ligand CSF-1, independently of alternate ligand, IL-34. Accordingly, CSF-1 depletion Nestin+ cells led to severe transcriptional alterations microglia, while remained intact....
Abstract Microglia and brain-derived neurotrophic factor (BDNF) are essential for the neuroplasticity that characterizes critical developmental periods. The experience-dependent development of social behaviors—associated with medial prefrontal cortex (mPFC)—has a period during juvenile in mice. However, whether microglia BDNF affect remains unclear. Herein, we aimed to elucidate effects microglia-derived on behaviors mPFC development. Mice underwent isolation p21–p35 had increased Bdnf...
Abstract Social isolation during the juvenile critical window is detrimental to proper functioning of prefrontal cortex (PFC) and establishment appropriate adult social behaviors. However, specific circuits that undergo experience-dependent maturation regulate behavior are poorly understood. We identify a activation pattern parvalbumin-positive interneurons (PVIs) in dorsal-medial PFC (dmPFC) prior an active bout, or bout initiated by focal mouse, but not passive when mice explored stimulus...
Juvenile social experience is crucial for the functional development of forebrain regions, especially prefrontal cortex (PFC). We previously reported that isolation 2 weeks after weaning induces dysfunction and hypomyelination. However, effect on physiological properties PFC neuronal circuit remained unknown. Since hypomyelination due to prominent in deep-layer medial (mPFC), we focused types Layer-5 pyramidal cells mPFC: h-current (PH) nonprominent (non-PH) cells. found a 2-week leads...
Social isolation is an important factor in the development of psychiatric disorders. It necessary to develop effective psychological treatment, such as cognitive rehabilitation, for children who have already suffered from social isolation, neglect and rejection. We used socially isolated mice validate whether elaborate re-socialization after juvenile can restore hypomyelination medial prefrontal cortex (mPFC) attendant functions manifested mice. While underwent with (Re-IS mice) demonstrated...
Functional neuroimaging studies have suggested that prefrontal cortex dysfunction occurs in individuals with autism spectrum disorder (ASD). Near-infrared spectroscopy (NIRS) is a noninvasive optical tool used to investigate oxygenation and hemodynamic responses the cerebral by measuring changes oxygenated hemoglobin. Previous using NIRS male children ASD exhibit reduced dorsolateral cortex; however, only few examined this response adults ASD. We characteristics of 114 84 typically...
Abstract Background Neuromodulation has become a promising treatment approach for psychiatric disorders. Previous studies have suggested that repetitive transcranial magnetic stimulation(rTMS) may modulate neuronal activity and improve variety of mental health conditions, including depression, catatonia, insomnia, as well hallucinations obsessive-compulsive disorder, post-traumatic stress drug abuse also been (Richter, 2023. Rashidi, 2017). However, its effects on diverse symptoms the...
Abstract Aim Autism spectrum disorder (ASD) is a neurodevelopmental condition that markedly impairs the physical, emotional, and social domains of health‐related quality life (HRQOL). Children with ASD typically report lower HRQOL than their neurotypical peers. This study investigated impact self‐esteem depressive symptoms on in children explored discrepancies between parent‐reported self‐reported HRQOL. Methods involved 94 participants, comprising 50 44 developed. was measured using...
Abstract Dendritic spine abnormalities are believed to be one of the critical etiologies autism spectrum disorder (ASD). Over past decade, importance microglia in brain development, particularly synaptic elimination, has become evident. Thus, microglial may lead dysfunction, which underlie pathogenesis ASD. Several human studies have demonstrated aberrant activation brains individuals with ASD, and animal models ASD also shown a relationship between dysfunction abnormalities. However, there...
A growing body of evidence suggests that immune dysfunction and inflammation in the peripheral tissues as well central nervous system are associated with neurodevelopmental deficits observed autism spectrum disorder (ASD). Elevated expression pro-inflammatory cytokines plasma, serum, blood mononuclear cells ASD has been reported. These cytokine levels severity behavioral impairments symptoms ASD. In a prior study, our group reported tumor necrosis factor-α (TNF-α) granulocyte-macrophage...
Recent studies have revealed that social experience affects myelination. These findings important implications for disorders feature abnormal myelination, such as multiple sclerosis (MS), previous shown psychosocial stress exacerbates the pathobiology of MS. However, most focused on during demyelination phase MSand not investigated effects remyelination. Thus, current study sought to determine whether can alter remyelination aftermyelindepletion. Myelininthemousemedialprefrontal...
Cognitive impairment is an important predictor of functional outcome in patients with attention deficit/hyperactivity disorder (ADHD). However, the neurophysiology ADHD-related cognitive impairments remains unclear. Event-related potentials (ERPs) represent noninvasive measurement neural correlates function. Mismatch negativity (MMN) ERP component that presumed to index preattentive monitoring changes auditory environment.Previous studies have shown altered MMN amplitude and latency ADHD....
During brain development, the design of primary neural networks is primarily determined by environmental stimuli after their formation. In particular, juvenile period critical, during which neuronal circuits that consist both excitatory and inhibitory neurons are remodeled experience. Social isolation profoundly affects development contributes to psychiatric disorders. We previously reported 2 weeks social weaning reduced synaptic inputs intrinsic excitability in a subtype layer 5 pyramidal...
Abstract Despite some slight differences in symptomatology, differential diagnosis of methamphetamine-induced psychosis (MAP) versus schizophrenia can be challenging because both disorders present a large overlap their clinical symptoms. However, recent study has shown that near-infrared spectroscopy (NIRS) performed during cognitive task powerful tool to differentiate between these two disorders. Here, we evaluated verbal fluency performance NIRS 15 patients diagnosed with MAP and 19...
Aim Adverse childhood experiences are potentially traumatic events with long‐lasting effects on the health and well‐being of patients autism spectrum disorder (ASD). It is important to clarify which types autism‐related symptoms influenced by design future intervention studies. However, few studies have examined association between autistic in large samples adults ASD individuals typical development (TD). In this study, we evaluate adverse multiple phenotypes among both those TD. Method We...
Tourette's disorder (TD) is a chronic childhood-onset characterized by the presence of multiple motor and vocal tics. Despite strong evidence that pathophysiology TD involves structural functional disturbances basal ganglia cortical frontal areas, in vivo imaging studies have produced conflicting results. Recent developments near-infrared spectroscopy (NIRS) technology enabled noninvasive assessment brain function people with psychiatric disorders. We asked 10 individuals pediatric healthy...
The etiology of autism spectrum disorder (ASD) is complex, and its pathobiology characterized by enhanced inflammatory activities; however, the precise underlying causes ASD remain unclear. This study was performed to identify indicators useful for diagnosing ASD. mRNA expression cytokines, including tumor necrosis factor-α (TNF-α), measured in cultured M1 M2 macrophages from patients with (n = 29) typically developed (TD) individuals 30). Additionally, TNF-α monocytes 7), showing...