A5021792801- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Nicotinic Acetylcholine Receptors Study
- Immune cells in cancer
- Nerve injury and regeneration
- Cell Image Analysis Techniques
- Axon Guidance and Neuronal Signaling
- Photoreceptor and optogenetics research
- Epilepsy research and treatment
- Neuroendocrine regulation and behavior
- Neurological disorders and treatments
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Advanced Fluorescence Microscopy Techniques
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Protein Degradation and Inhibitors
- Electromagnetic Scattering and Analysis
- Cholinesterase and Neurodegenerative Diseases
- Autoimmune Neurological Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Iron Metabolism and Disorders
- Mitochondrial Function and Pathology
- Advanced Neuroimaging Techniques and Applications
Nagoya University
2020-2025
Nurix (United States)
2020-2024
Chubu Gakuin University
2024
Nagoya City University
2011-2023
National Institute for Physiological Sciences
2018-2023
National Institutes of Natural Sciences
2018-2023
Mizuho (Japan)
2023
Icahn School of Medicine at Mount Sinai
2020-2021
Sapporo City General Hospital
2021
Child Health and Development Institute
2021
Abstract Microglia survey brain parenchyma, responding to injury and infections. also respond systemic disease, but the role of blood–brain barrier (BBB) integrity in this process remains unclear. Using simultaneous vivo imaging, we demonstrated that inflammation induces CCR5-dependent migration resident microglia cerebral vasculature. Vessel-associated initially maintain BBB via expression tight-junction protein Claudin-5 make physical contact with endothelial cells. During sustained...
<h3>Objective</h3> To investigate the morphological features of chronic inflammatory demyelinating polyneuropathy (CIDP) with autoantibodies directed against paranodal junctional molecules, particularly focusing on fine structures paranodes. <h3>Methods</h3> We assessed sural nerve biopsy specimens obtained from 9 patients CIDP anti-neurofascin-155 antibodies and 1 patient anti-contactin-1 antibodies. 13 without these were also examined to compare pathological findings. <h3>Results</h3>...
Microglia are highly motile immunoreactive cells that play integral roles in the response to brain infection and damage, progression of various neurological diseases. During development, microglia also help sculpt neural circuits, via both promoting synapse formation by targeting specific synapses for elimination phagocytosis. active surveyors circuits mature, healthy brain, although functional consequences such microglia-neuron contacts under these conditions is unclear. Using vivo imaging...
Bruton's tyrosine kinase (BTK), a member of the TEC family kinases, is an essential effector B-cell receptor (BCR) signaling. Chronic activation BTK-mediated BCR signaling hallmark many hematological malignancies, which makes it attractive therapeutic target. Pharmacological inhibition BTK enzymatic function now well-proven strategy for treatment patients with these malignancies. We report discovery and characterization NX-2127, degrader concomitant immunomodulatory activity. By design,...
Abstract Social isolation during the juvenile critical window is detrimental to proper functioning of prefrontal cortex (PFC) and establishment appropriate adult social behaviors. However, specific circuits that undergo experience-dependent maturation regulate behavior are poorly understood. We identify a activation pattern parvalbumin-positive interneurons (PVIs) in dorsal-medial PFC (dmPFC) prior an active bout, or bout initiated by focal mouse, but not passive when mice explored stimulus...
Abstract Objective Brain iron accumulation has been proposed as one of the pathomechanisms in Parkinson's disease (PD). This study aimed to examine whole‐brain pattern associated with cognitive impairment patients PD using voxel‐based quantitative susceptibility mapping analysis. Methods We enrolled 24 and mild impairment, 22 normal cognition, 20 age‐matched healthy controls this cross‐sectional study. All participants underwent global physical assessments brain MRI. Using a combined method...
Abstract Maternal infection or inflammation causes abnormalities in brain development associated with subsequent cognitive impairment and an increased susceptibility to schizophrenia autism spectrum disorders. immune activation (MIA) increases serum cytokine levels mediates this association via effects on the fetal brain, microglia can respond maternal status, but consensus how may is lacking no-one has yet examined if microglial process motility impaired. In study we investigated MIA...
Abstract Myelination increases the conduction velocity in long‐range axons and is prerequisite for many brain functions. Impaired myelin regulation or impairment of itself frequently associated with deficits learning cognition neurological psychiatric disorders. However, it has not been revealed what perturbation neural activity induced by causes deficits. Here, we measured motor cortex during transgenic mice a subtle their myelin. This deficit impaired learning, was accompanied decrease...
Although immobility is a common cause of muscle atrophy, the mechanism underlying this causality unclear. We here show that Krüppel-like factor 15 (KLF15) and IL-6 are upregulated in skeletal limb-immobilized mice with KLF15 deficiency or systemic protected from immobility-induced atrophy. A newly developed Ca2+ bioimaging revealed cytosolic concentration ([Ca2+]i) reduced to below basal level by immobilization, which associated downregulation Piezo1. Acute disruption Piezo1 induced Klf15...
Upregulation of N-type Ca 2+ channel dependent subunits increases functional connections and synchronization for pain formation.
The relationships between tissue-resident microglia and early macrophages, especially their lineage segregation outside the yolk sac, have been recently explored, providing a model in which conversion from macrophages seeds during brain development. However, spatiotemporal evidence to support such microglial seeding situ explain how it occurs has not obtained. By cell tracking via slice culture, intravital imaging, Flash tag-mediated or genetic labeling, we find that intraventricular CD206+...
Cross-modal plasticity is the repurposing of brain regions associated with deprived sensory inputs to improve capacity other modalities. The functional mechanisms cross-modal can indicate how recovers from various forms injury and different modalities are integrated. Here, we demonstrate that rewiring microglia-mediated local circuit synapse crucial for induced by visual deprivation (monocular [MD]). MD relieves usual inhibition connectivity between somatosensory cortex secondary lateral...
A pathological excitatory action of the major inhibitory neurotransmitter γ-aminobutyric acid (GABA) has been observed in epilepsy. Blocking Cl- importer NKCC1 with bumetanide is expected to reduce neuronal intracellular concentration ([Cl- ]i ) and thereby attenuate GABA response. Accordingly, several clinical trials for epilepsy were conducted. Although expressed both neurons glial cells, an involvement seizures not yet reported. Astrocytes maintain high [Cl- NKCC1, this gradient promotes...
Cross-sensitivity of rash has been reported between various antiepileptic drugs (AEDs). However, few studies have determined the frequency and management cross-sensitivity in patients with super-refractory status epilepticus (SRSE).To examine optimal AED for treating SRSE cross-sensitivity.We performed a retrospective review adult treated at Nagoya City University Hospital, which we investigated among their clinical medical profiles.We identified 10 SRSE, 5 whom had cross-sensitivity....
Thymic carcinoma is a rare and aggressive tumor, the efficacy of second-line chemotherapy still unclear. Here, we reported case thymic that responded well to administration docetaxel alone as chemotherapy. A 64-year-old woman was diagnosed with (squamous cell type) bone metastasis, she, therefore, received nedaplatin combined etoposide ifosfamide. She partially, after which she irradiation for metastasis. Two months chemotherapy, exhibited gradual regrowth experienced shoulder pain. We...
Neonicotinoid pesticides (NNs) cause behavioral abnormalities in mammals, raising concerns about their effects on neural circuit activity. We herein examined the neurological of NN clothianidin (CLO) by vivo Ca2+ imaging using two-photon microscopy. Mice were fed no-observed-adverse-effect-level (NOAEL) dose CLO for 2 weeks and neuronal activity primary somatosensory cortex (S1) was observed weekly weeks. exposure caused a sustained influx neurons S1 2/3 layers, indicating hyperactivation...
Brain function relies on both rapid electrical communication in neural circuitry and appropriate patterns or synchrony of activity. Rapid between neurons is facilitated by wrapping nerve axons with insulation a myelin sheath composed largely different lipids. Recent evidence has indicated that the extent myelination can adapt based activity levels this adaptive associated improved learning motor tasks, suggesting such plasticity may enhance effective learning. In study, we examined whether...
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a type of autoimmune that can be paraneoplastic and usually responds to tumor resection immunotherapy. More than 75% patients with anti-NMDAR fully recover or have only mild sequelae, whereas the remainder experience severe disability. It remains unknown why certain cases refractory clinical disease courses. We report case bilateral ovarian teratomas who was early initiation During intensive care, immunohistochemical analyses her...
Although several studies have demonstrated correlation between white matter hyperintensities (WMH) and impairment of executive functions, the underlying anatomical-functional relationships are not fully understood. The present study sought to investigate correlations volume WMH medial temporal lobe atrophy (MTA) using quantitative magnetic resonance image (MRI) a variety function assessments. A total 91 patients ranging in age from 58 90 years with mild cognitive (MCI) due Alzheimer's...