A5051390519- Anesthesia and Pain Management
- Pain Mechanisms and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Pain Management and Opioid Use
- Pain Management and Treatment
- Pituitary Gland Disorders and Treatments
- Airway Management and Intubation Techniques
- Diabetes Management and Research
- Sepsis Diagnosis and Treatment
- Musculoskeletal pain and rehabilitation
- Electrolyte and hormonal disorders
- Electroconvulsive Therapy Studies
- Spine and Intervertebral Disc Pathology
- Nausea and vomiting management
- Cancer, Stress, Anesthesia, and Immune Response
- Mechanical Circulatory Support Devices
- Adrenal and Paraganglionic Tumors
- Nerve injury and regeneration
Kobe University Hospital
2016-2025
Kobe University
2016-2025
Himeji Medical Center
2023
Kobe Institute Of Computing
2023
Creative Research Enterprises (United States)
2018
Alexandria University
2016
Okayama University
2003-2014
Marymount University
2004
Okayama University Hospital
1997-2003
Okayama Prefectural University
2002
Chronic pain conditions such as phantom limb and complex regional syndrome are difficult to treat, traditional pharmacological treatment invasive neural block not always effective. Plasticity in the central nervous system occurs these may be associated with pain. Mirror visual feedback therapy aims restore normal cortical organization is applied of chronic conditions. However, all patients benefit from this treatment. Virtual reality technology increasingly attracting attention for medical...
Upregulation of N-type Ca 2+ channel dependent subunits increases functional connections and synchronization for pain formation.
If the epidural spread of contrast medium can be well correlated with local anesthetics, epidurography predict dermatomal distribution anesthetic block. The authors evaluated relation between radiographic and analgesic spread.An catheter was inserted in 90 patients, predicted tip position recorded. area determined by pinprick after a 5-ml injection 1.5% lidocaine, performed 240 mg I/ml iotrolan. Patients were assigned to three groups according (group C: C-T4; group T: T5-T10; L: T11-L),...
General anesthesia for patients with poor pulmonary function is a risk factor perioperative complications, and it should be avoided as much possible, depending on the specifics of each case. Herein, anesthetic management partial mastectomy in patient using intertransverse process block (ITPB) reported. A woman her 80s (height 149 cm, weight 45.9 kg) was scheduled to undergo right breast cancer. She had bronchiectasis interstitial pneumonia. ITPB performed, intravenous dexmedetomidine...
Under general anesthesia, lidocaine shortens the onset time of vecuronium but it does not affect that rocuronium. We suspected dose rocuronium used in previous reports, 0.6 mg/kg, was too high to detect any difference due lidocaine's effect. investigated effects 1.5 mg/kg on time, 50% depression 100% and duration action 0.4 Sixty adult patients who underwent elective operation under anesthesia without tracheal intubation were randomly divided into two groups: including a group (LG) placebo...
Abstract Background Postoperative patients constitute majority of critically ill patients, although factors predicting extubation failure in this group remain unidentified. Aiming to propose clinical predictors reintubation postoperative we conducted a post-hoc analysis multicenter prospective observational study. Methods This study included who underwent mechanical ventilation for > 24 h and were extubated after successful 30-min spontaneous breathing trial. The primary outcome was...
Purpose Nafamostat mesilate (NM) can be used as a regional anticoagulant for continuous renal replacement therapy (CRRT). The primary aim of this study was to assess the association use NM with risk bleeding complications and compare it unfractionated heparin (UFH). Methods We conducted single-center retrospective observational study. included adult patients who required CRRT in our intensive care unit from 2011 2013. outcome during secondary filter life first CRRT. Results 101 (76 NM, 25...
Acute kidney injury (AKI) often occurs after cardiac surgery. During surgery, plasma free hemoglobin (fHb) would increase due to hemolysis. Since fHb is thought be nephrotoxic, haptoglobin, which an scavenger, may have the potential prevent postoperative AKI (pAKI). However, there been few studies in association of intraoperative administration haptoglobin with incidence surgery was assessed.This study a retrospective observational assess independent pAKI patients. We screened patients who...
The long-term effect of percutaneous electrical nerve stimulation (PENS) on chronic low back pain (LBP) is unclear. We evaluated the number sessions for which PENS should be performed to alleviate LBP and how long analgesia sustained. Patients underwent treatment a twice-weekly schedule 8 wk. Group A (n = 18) received wk, group B 17) first 4 wk transcutaneous (TENS) second C TENS Pain level, degree physical impairment, daily intake nonsteroidal antiinflammatory drugs (NSAIDs) were assessed...
Abstract Background Although 5-aminolevulinic acid is useful for the photodynamic diagnosis of bladder tumors, it often causes severe intraoperative hypotension. We report a case postoperative cardiac arrest in addition to hypotension, probably owing use acid. Case presentation An 81-year-old Japanese man was scheduled undergo transurethral resection tumor. The patient took orally 2 hours before entering operating room. After induction anesthesia, his blood pressure decreased 47/33 mmHg....
Summary Background Exposure to some anesthetic agents during the fetal period has been shown induce neurodegeneration or learning deficits in animal models. Sevoflurane is one of most prevalent general anesthetics; however, influence sevoflurane at a clinically relevant concentration on developing brain remains unknown. Objective We investigated whether single exposure would affect neuronal development and learning/memory ability mice. Methods Pregnant mice gestational day 17 were...
Objective To investigate whether tin chloride pretreatment ameliorates renal injury in rats with ischemic acute failure (IARF) by virtue of its kidney-specific heme oxygenase-1 induction. Design Randomized, masked, controlled animal study. Setting University-based research facility. Subjects Sprague-Dawley male rats, weighing 200–230 g (n = 359). Interventions Rats were injected subcutaneously, because subcutaneous administration is known to specifically and potently induce oxygenase...
Secreted frizzled-related protein 2, (SFRP2) is a Wnt inhibitor whose promoter CpGs were recently found to be methylated at high frequency in colorectal cancers (CRCs). We hypothesized that the pattern of SFRP2 methylation may differ throughout during progressive tumorigenesis. Using combined bisulfite restriction analysis (COBRA), two methylation-sensitive regions (Regions A and B) investigated 569 specimens tissue:222 CRCs, 103 adenomatous polyps (APs), 208 normal colonic mucosa from CRC...
Abstract Background Various factors can cause vascular endothelial damage during cardiovascular surgery (CVS) with cardiopulmonary bypass (CPB), which has been suggested to be associated postoperative complications. However, few studies have specifically investigated the relationship between degree of and acute kidney injury (pAKI). The objectives this study were measure perioperative serum syndecan-1 concentrations in patients who underwent CVS CPB, evaluate their trends, determine...
Abstract: Metastatic bone cancer causes severe pain, but current treatments often provide insufficient pain relief. One of the reasons is that mechanisms underlying are not solved completely. Our previous studies have shown brain-derived neurotrophic factor (BDNF), known as a member family, an important molecule in pathological state some models. We hypothesized expression changes BDNF may be one factors related to pain; this study, we investigated dorsal root ganglia rat model. As expected,...
Kinesin superfamily proteins are microtubule-based molecular motors driven by the energy of ATP hydrolysis. Among them, kinesin-4 family is a unique motor that inhibits microtubule dynamics. Although mutations cause several diseases, its mechanism unclear because difficulty visualizing high-resolution structure working at plus-end. Here, we report KLP-12, C. elegans ortholog KIF21A and KIF21B, essential for proper length control axons, domain represses polymerization in vitro. The crystal...
Although epidural anesthesia prevents immune suppression during surgery, no reports have elucidated how block affects response in nonsurgical patients. We examined changes proportion of lymphocyte subsets and natural-killer (NK) cell activity patients with without pain. Fifteen pain (Pain group) 15 preoperative (Preoperative received three different treatments random order: 7 mL 1% lidocaine, injection an identical volume normal saline, IV 1 mg/kg lidocaine. Blood samples were drawn before...
In Brief Heme oxygenase-1 (HO-1) is induced by oxidative stress and thought to confer protection against tissue injuries. HO-1 catalyzes the conversion of heme moiety hemeproteins, such as hemoglobin, myoglobin, cytochrome P450, biliverdin, liberating carbon monoxide (CO) in process. CO reacts with hemoglobin form carboxyhemoglobin. this study, examine effect anesthesia and/or surgery on endogenous production, we measured amount exhaled arterial carboxyhemoglobin concentration patients who...