A5044806057- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Neurofibromatosis and Schwannoma Cases
- Cancer, Hypoxia, and Metabolism
- Spinal Fractures and Fixation Techniques
- Facial Nerve Paralysis Treatment and Research
- Advanced MRI Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- CNS Lymphoma Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Moyamoya disease diagnosis and treatment
- Mitochondrial Function and Pathology
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Trigeminal Neuralgia and Treatments
Kobe University
2016-2025
Kinki Central Hospital
2021-2025
Kobe Design University
2024
Kobe University Hospital
2005-2022
Kobe Institute Of Computing
2020
Teijin (Japan)
2013-2020
Oxford University Press (United Kingdom)
2020
The University of Tokyo
2019
SAS Institute (United States)
2019
Environmental Systems Research Institute (United States)
2019
MicroRNAs (miRNAs) are effective post-transcriptional regulators of gene expression and important in many biological processes. Although the oncogenic tumor suppressive functions several miRNAs have been characterized, role mediating invasion migration remains largely unexplored. Recently, miR-10b was identified as an miRNA highly expressed metastatic breast cancer, promoting cell invasion. Here, we performed real-time reverse transcriptase polymerase chain reaction (RT-PCR) assays on 43...
The mechanistic target of rapamycin (mTOR) is hyperactivated in many types cancer, rendering it a compelling drug target; however, the impact mTOR inhibition on metabolic reprogramming cancer incompletely understood. Here, by integrating and functional studies glioblastoma multiforme (GBM) cell lines, preclinical models, clinical samples, we demonstrate that compensatory upregulation glutamine metabolism promotes resistance to kinase inhibitors. Metabolomic GBM cells revealed glutaminase...
Aurora-A, a member of the Aurora/Ipl1-related kinase family, is overexpressed in various types cancer and considered to play critical roles tumorigenesis. To better understand pathological effect Aurora-A activation, it first necessary elucidate physiological functions Aurora-A. Here, we have investigated mitotic progression with small interfering RNA, antibody microinjection, time lapse microscopy using human cells. We demonstrated that suppression by RNA caused multiple events fail...
Here we report the cloning and functional characterization of a rat novel peptide/histidine transporter (PHT1), which was expressed in brain retina. The cDNA encodes predicted protein 572 amino acid residues with 12 putative membrane-spanning domains. sequence has moderate homology nonspecific peptide found plant. When Xenopus laevis oocytes, PHT1 cRNA induced high affinity proton-dependent histidine transport activity. This process inhibited by dipeptides tripeptides but not free acids such...
In the focal infarction model of rat middle cerebral artery (MCA), thalamus occluded side becomes gradually atrophic, mainly because retrograde degeneration. We determined whether basic fibroblast growth factor (bFGF) administered intracisternally could prevent this thalamic atrophy. left MCA through a small cranial opening, and animals were then divided into two groups. One group received intra-cisternal injections recombinant bFGF (1 μg dissolved in 0.1 ml saline with 2% serum) starting 1...
The diagnosis of primary central nervous system lymphoma (PCNSL) by radiographical examination is often difficult because its similarity to other brain tumors. To test whether interleukin-10 (IL-10) and IL-6 can be used distinguish PCNSL from tumors that are radiographically similar, cerebrospinal fluid (CSF) levels IL-10 were measured in 66 patients with intracranial (PCNSLs: 26 cases; tumors: 40 cases). In the PCNSLs, median CSF 27 pg/mL 5.4 pg/mL, respectively. significantly higher PCNSLs...
Recently, successful predictions using machine learning (ML) algorithms have been reported in various fields. However, traumatic brain injury (TBI) cohorts, few studies examined modern ML algorithms. To develop a simple model for TBI outcome prediction, we conducted performance comparison of nine algorithms: ridge regression, least absolute shrinkage and selection operator (LASSO) random forest, gradient boosting, extra trees, decision tree, Gaussian naïve Bayes, multi-nomial support vector...
Object. Twenty-nine nonimmunocompromised patients with primary central nervous system (CNS) lymphoma were treated high-dose methotrexate (MTX) therapy followed by irradiation. The authors investigated the correlation of infusion schedules MTX penetration into cerebrospinal fluid (CSF), tumor response, and survival to develop a regimen that would lead better clinical results. Methods. In this study, 100 mg/kg was administered on either rapid (3-hour) or regular (6-hour) schedule for two three...
Metabolomics has recently undergone rapid development; however, metabolomic analysis in cerebrospinal fluid (CSF) is not a common practice. We analyzed the metabolite profiles of preoperative CSF samples from 32 patients with histologically confirmed glioma using gas chromatography/mass spectrometry (GC/MS). assessed how alterations levels were related to World Health Organization (WHO) tumor grades, location, gadolinium enhancement on magnetic resonance imaging (MRI), and isocitrate...
Traumatic brain injury (TBI) often impairs cognitive function. Diffusion tensor (DT) imaging, a novel modality, permits evaluation of the effects head trauma on white matter nerve fibers. The objectives current study were to investigate where following mild moderate TBI is specifically located DT imaging in acute disease stage and examine relationship between severity lesion future function chronic stage.Twenty adult patients with (Glasgow Coma Scale score 9 15) underwent conventional MR...
In 1998, the Guidelines Committee on Management of Severe Head Injury was established by Japan Society Neurotraumatology, and performed a critical review national international studies published over past 10 years. The guidelines were first in 2000 based results this literature consensus, 2nd revised edition 2006. This English version is intended to promote its concepts use worldwide.
Mutations in the isocitrate dehydrogenase 1 (IDH1) gene that are frequently observed low-grade glioma strongly associated with accumulation of 2-hydroxyglutarate (2HG), which is a valuable diagnostic and prognostic biomarker IDH1 mutant glioma. However, conventional MR spectroscopy (MRS)–based noninvasive detection 2HG challenging. In this study, we aimed to determine additional value other metabolites predicting mutations MRS. Forty-seven patients underwent single voxel short echo time MRS...
Abstract BACKGROUND Microvascular decompression (MVD) is the most effective procedure for long-term management of trigeminal neuralgia (TGN). However, retrospective and single-center studies are inherently biased, there currently no prospective, multicenter studies. OBJECTIVE To evaluate short- outcomes complications in patients with TGN who underwent MVD at specialized Japanese institutions. METHODS We enrolled between April 2012 March 2015. recorded their facial pain grade 7 d (short...
Abstract Cancer cells optimize nutrient utilization to supply energetic and biosynthetic pathways. This metabolic process also includes redox maintenance epigenetic regulation through nucleic acid protein methylation, which enhance tumorigenicity clinical resistance. However, less is known about how cancer exhibit flexibility sustain cell growth survival from starvation. Here, we find that serine glycine levels were higher in low-nutrient regions of tumors glioblastoma multiforme (GBM)...
alpha-Carotene inhibited the proliferation of human neuroblastoma cell line GOTO in a dose- and time-dependent manner. In addition, it was about 10 times more inhibitory than beta-carotene. Northern blot analysis indicated that alpha-carotene caused maximum suppression level N-myc messenger RNA cells. This occurred within 18 hours treatment, after which gradually recovered to basal level. Analysis by flow cytometry when cells were exposed alpha-carotene, they arrested G0-G1 phase their...
Background and Purpose— Hyperperfusion syndrome is a rare but disastrous complication after carotid endarterectomy (CEA). The aim of this study was to investigate the relationship between preoperative cerebral blood flow (CBF) abnormalities postoperative hyperperfusion through use statistical brain mapping analysis. Methods— For 41 patients with unilateral stenosis ≥70%, CBF vasoreactivity (CVR) were investigated resting acetazolamide-challenge single photon emission CT before CEA. 1 day CEA...
Object. To enhance visual confirmation of regional anatomy, endoscopy was introduced during microsurgery for cerebral aneurysms. The risks and benefits are analyzed in the present study. Methods. endoscopic technique used 54 aneurysms 48 patients. Forty-three were located anterior circulation 11 posterior circulation. Thirty-eight (70.4%) had not ruptured. All ruptured series produced Hunt Hess Grade I or II subarachnoid hemorrhage. After initial exposure achieved with aid a microscope,...