A5031424137- Neuroscience and Neuropharmacology Research
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Advanced X-ray Imaging Techniques
- Vascular Malformations Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Brain Metastases and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Cervical and Thoracic Myelopathy
- Advanced Radiotherapy Techniques
- Nicotinic Acetylcholine Receptors Study
- Pluripotent Stem Cells Research
- Advanced MRI Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Spinal Dysraphism and Malformations
- Lung Cancer Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
Shizuoka General Hospital
2018-2023
Shinko Hospital
2011-2022
Nerima General Hospital
2021
Kobe University
2004-2016
Gifu Heart Center
2015
Canon (Japan)
2011-2014
High Pressure Gas Safety Institute of Japan
2009
Japan Synchrotron Radiation Research Institute
2006
Tokyo University of Science
2006
Hokkaido University
1977-2002
MicroRNAs (miRNAs) are effective post-transcriptional regulators of gene expression and important in many biological processes. Although the oncogenic tumor suppressive functions several miRNAs have been characterized, role mediating invasion migration remains largely unexplored. Recently, miR-10b was identified as an miRNA highly expressed metastatic breast cancer, promoting cell invasion. Here, we performed real-time reverse transcriptase polymerase chain reaction (RT-PCR) assays on 43...
Abstract A low concentration (10 nM) of adenosine potentiated hippocampal neuronal activity via 2a receptors without affecting presynaptic glutamate release or postsynaptic glutamatergic conductance. Adenosine inhibited uptake through the glial transporter, GLT‐1, receptors. In addition, stimulated GLT‐1‐independent from astrocytes, possibly in response to a rise intracellular Ca 2+ , involving PKA activation. Those actions could lead an increase synaptic concentrations responsible for...
We demonstrate a single shot two-dimensional grating-based X-ray phase-contrast imaging using synchrotron radiation source. A checkerboard designed phase grating for π modulation at 17 keV and 35 keV, lattice-shaped amplitude with high aspect ratio to shield X-rays up were fabricated. Fourier analysis of Moiré fringe generated by the gratings was introduced obtain differential image exposure. The results show that soft tissues cartilages chicken wing sample are clearly seen variation in...
OBJECTIVE In order to obtain better local tumor control for large (i.e., > 3 cm in diameter or 10 volume) brain metastases (BMs), 3-stage and 2-stage Gamma Knife surgery (GKS) procedures, rather than a palliative dose of stereotactic radiosurgery, have been proposed. Here, authors conducted retrospective multi-institutional study compare treatment results between GKS BMs. METHODS This involved 335 patients from 19 facilities Japan. Major inclusion criteria were 1) newly diagnosed BMs, 2)...
We, for the first time, performed in vivo x-ray angiography mouse brain using SPring-8, a third-generation synchrotron radiation facility.A thin PE-50 tube was placed unilateral external carotid artery adult male C57BL/6J mice. While maintaining blood flow internal artery, 33 muL of contrast agent injected and then selective hemisphere performed.The average diameters cerebral were as follows: 142.5+/-7.90 microm middle 138.3+/-9.35 anterior 120.5+/-5.53 posterior 162.6+/-10.87 (n=5). To...
OBJECTIVE This study aimed to explore the efficacy and safety of stereotactic radiosurgery in patients with jugular foramen schwannomas (JFSs). METHODS was a multiinstitutional retrospective analysis 117 JFSs who were treated Gamma Knife surgery (GKS) at 18 medical centers Japan Leksell Society. The median age 53 years. Fifty-six underwent GKS as their initial treatment, while 61 had previously undergone resection. At time GKS, 46 (39%) hoarseness, 45 (38%) hearing disturbances, 43 (36%)...
A Talbot-Lau interferometer using two-dimensional gratings and a conventional x-ray tube has been used to investigate phase-contrast imaging technique that is sensitive phase gradients in two orthogonal directions. Fourier analysis of Moiré fringe patterns was introduced obtain differential images scattering from single exposure. Two-dimensional structures plastic phantoms characteristic features soft tissue were clearly obtained at 17.5 keV. The phase-stepping also examined the spatial...
Taxol is an effective anti-tumour drug against a variety of tumour cells. directly induces apoptosis in addition to G2/M cell cycle arrest. However, it remains poorly understood how the secretion inflammatory cytokines murine macrophages toll-like receptor-4 (TLR-4)-dependent manner its effects, but effect on human controversial. In this study, we demonstrated that low doses (less than 1000 nmol/l) induced expression necrosis factor (TNF)-alpha myelomonocytic cells and induction TNF-alpha...
The tumoricidal mechanisms of microbeam radiation therapy, and the more recently proposed minibeam for treatment brain tumors are as yet unclear. Moreover, from among various parameters beam geometry impact changing width is unknown. In this study, suppression tumor growth in human glioma cells implanted mice was evaluated experimentally using microbeams two different widths: a conventional narrow (20 µm width, 100 center-to-center distance) wide (100 500 distance). ratio compared acute cell...
A group study for symptomatic cavernous malformation (CM) treated with gamma knife (GK) surgery was performed.A total of 298 cases collected from 23 GK centers across Japan were included. Hemorrhage the most common manifestation, followed by seizures and neurological deficits. Most lesions located in brainstem basal ganglia, cerebral or cerebellar hemispheres. The CMs, which had a mean diameter 14.8 mm, using marginal dose 14.6 Gy.In terms hemorrhage-free survival (HFS), marked dissociation...
Abstract Micro-slit-beam radiation therapy (MRT) using synchrotron-generated X-ray beams allows for extremely high-dose irradiation. However, the toxicity of MRT in central nervous system (CNS) use is still unknown. To gather baseline toxicological data, we evaluated mortality normal mice following CNS-targeted MRT. Male C57BL/6 J were head-fixed a stereotaxic frame. Synchrotron X-ray-beam was provided by SPring-8 BL28B2 beam-line. For MRT, delivered to groups 10 × 12 mm unidirectional array...
Twenty-four intracranial aneurysms over 20 mm in diameter were studied with magnetic resonance (MR) imaging. MR imaging follow-up of eight cases revealed induced thrombus homogeneous intensity and decreased size even after complete intraluminal thrombosis. Most demonstrated contrast to the heterogeneous spontaneous thrombus. The clinical symptoms could not be explained retrospectively by characteristics. Perianeurysmal high intensity, indicating cerebral edema, was detected one case...
A 49-year-old man was admitted suffering from headache persisting for a month. He had history of primary spinal intramedullary malignant melanoma at the T6 level 18 years previously, which remained stable years. Magnetic resonance imaging revealed central nervous system (CNS) dissemination melanoma. Whole brain radiation therapy (30 Gy), local (15 and routine intrathecal injection interferon beta were performed. The progression CNS controlled without neurological deterioration 38 months....
The incidences of metastatic brain tumors from malignant melanomas have increased and survival has been prolonged by novel molecular targeted agents immunotherapy. However, are uncommon in Asian populations.We retrospectively analyzed treatment efficacy identified prognostic factors impacting tumor control Japanese melanoma patients with metastases treated gamma knife radiosurgery (GKRS).We reviewed the medical records 177 1,500 who underwent GKRS for melanomas. This study was conducted...