A5101660513- Glioma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Lymphoma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Cancer, Hypoxia, and Metabolism
- Vascular Malformations Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cerebrovascular and Carotid Artery Diseases
- Cerebrospinal fluid and hydrocephalus
- Cancer-related molecular mechanisms research
- Neurofibromatosis and Schwannoma Cases
- Neuroendocrine Tumor Research Advances
- Head and Neck Surgical Oncology
- Lung Cancer Research Studies
- Vascular Malformations and Hemangiomas
- Cancer Treatment and Pharmacology
- Salivary Gland Tumors Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Colorectal Cancer Treatments and Studies
- Fetal and Pediatric Neurological Disorders
- Diet and metabolism studies
Kobe University
2001-2024
Kobe City Nishi-Kobe Medical Center
2016-2024
Kobe Medical Center
2013-2022
CTO Andrea Alesini
2016
Fondazione IRCCS Istituto Neurologico Carlo Besta
2016
Institut de génétique et de développement de Rennes
2013
Fujita Health University Hospital
2013
Inserm
2013
Sorbonne Université
2013
Institut du Cerveau
2013
MicroRNAs (miRNAs) are effective post-transcriptional regulators of gene expression and important in many biological processes. Although the oncogenic tumor suppressive functions several miRNAs have been characterized, role mediating invasion migration remains largely unexplored. Recently, miR-10b was identified as an miRNA highly expressed metastatic breast cancer, promoting cell invasion. Here, we performed real-time reverse transcriptase polymerase chain reaction (RT-PCR) assays on 43...
The diagnosis of primary central nervous system lymphoma (PCNSL) by radiographical examination is often difficult because its similarity to other brain tumors. To test whether interleukin-10 (IL-10) and IL-6 can be used distinguish PCNSL from tumors that are radiographically similar, cerebrospinal fluid (CSF) levels IL-10 were measured in 66 patients with intracranial (PCNSLs: 26 cases; tumors: 40 cases). In the PCNSLs, median CSF 27 pg/mL 5.4 pg/mL, respectively. significantly higher PCNSLs...
Metabolomics has recently undergone rapid development; however, metabolomic analysis in cerebrospinal fluid (CSF) is not a common practice. We analyzed the metabolite profiles of preoperative CSF samples from 32 patients with histologically confirmed glioma using gas chromatography/mass spectrometry (GC/MS). assessed how alterations levels were related to World Health Organization (WHO) tumor grades, location, gadolinium enhancement on magnetic resonance imaging (MRI), and isocitrate...
Abstract Increased tumor‐associated macrophages ( TAMs ) have been reported to be associated with poor prognosis in various tumors; however, the importance of primary central nervous system lymphoma PCNSL has not clarified. In 47 patients who were treated high‐dose methotrexate MTX and radiotherapy, relationships between infiltration levels clinicopathological parameters analyzed. Univariate analysis Cox proportional hazards model using continuous scales revealed that increased CD68 positive...
Abstract The ketogenic diet (KD) is a high fat and low carbohydrate that produces ketone bodies through imitation of starvation. combination KD Bevacizumab (Bev), VEGF inhibitor, considered to further reduce the supply glucose tumor. metabolite changes in U87 glioblastoma mouse models treated with and/or Bev were examined using gas chromatography-mass spectrometry. therapy showed decrease rate tumor growth an increase survival time mice, although alone did not have benefit. In metabolome...
Abstract Tumor biopsy is essential for the definitive diagnosis of central nervous system (CNS) lymphoma. However, procedure carries risk complications such as bleeding, convulsions, and infection. Cerebrospinal fluid (CSF) β2‐microglobulin (β2‐MG), soluble IL‐2 receptor (sIL‐2R), interleukin‐10 (IL‐10) are known to be useful diagnostic biomarkers CNS The C‐X‐C motif chemokine ligand 13 (CXCL13) was recently reported another biomarker purpose this study establish a algorithm that can avoid...
We compared the diagnostic yield and morbidity by frame-based computed tomography-guided stereotactic biopsy (CTSTB) with Brown-Roberts-Wells (BRW) unit neuronavigation-guided frameless (NSTB) using magnetic resonance imaging (MRI).The subjects' age range was 15-83 years. CTSTB BRW performed for 59 tumors (58 cases, 1988-2007). NSTB 38 (35 2007-2013) needle sheath attached to head holder. By NSTB, target locations of sampling points trajectories were confirmed MRI. Diffusion tensor...
A 49-year-old man was admitted suffering from headache persisting for a month. He had history of primary spinal intramedullary malignant melanoma at the T6 level 18 years previously, which remained stable years. Magnetic resonance imaging revealed central nervous system (CNS) dissemination melanoma. Whole brain radiation therapy (30 Gy), local (15 and routine intrathecal injection interferon beta were performed. The progression CNS controlled without neurological deterioration 38 months....
A 55-year-old woman presented with a rare xanthogranuloma of the sellar region after complaining severe headache and visual disturbance 3 months previously. Clinical examination showed she was alert early signs bitemporal hemianopsia. Endocrinological revealed hypopituitarism. Magnetic resonance imaging an intrasellar mass extending into suprasellar compressing optic chiasma, which appeared homogeneously hyperintense on T1-weighted images. Endonasal transsphenoidal resection tumor performed....
Abstract Background The purpose of the present study was to analyze recurrence pattern high-grade glioma treated with a multimodal treatment approach and evaluate whether MIB-1 labeling index (LI) could be useful marker for predicting failure in glioblastoma (GB). Methods materials We evaluated histologically confirmed 131 patients either anaplastic astrocytoma (AA) or GB. A median dose 60 Gy. Concomitant adjuvant chemotherapy were administered 111 patients. LI assessed by...
A 35-year-old female complained of right-sided watery nasal discharge persisting for 2 weeks. Neuroimaging investigations revealed a defect in the lateral side middle cranial fossa, temporal lobe encephalocele protruding into extension sphenoid sinus, and cerebrospinal fluid (CSF) collection on right sinus. The transcranial approach was performed resection obliteration base anterolateral to foramen spinosum with multilayered closure using autologous fat, bone graft, vascularized split...
A 33-year-old woman presented with rare brain metastases from undifferentiated high-grade sarcoma manifesting as headache and vomiting. Magnetic resonance (MR) imaging demonstrated multiple tumors in the brain, subcutaneous soft tissue, mediastinum. The patient underwent surgery, followed by chemotherapy radiotherapy. histological diagnosis was sarcoma. Radiotherapy effective, but recurred 6 months later. high-dose methotrexate therapy, showed no response. Promoter hypermethylation...