A5053890395- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Neurofibromatosis and Schwannoma Cases
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Genetic factors in colorectal cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Soft tissue tumor case studies
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Cancer and Skin Lesions
- Neuroblastoma Research and Treatments
- Advanced X-ray Imaging Techniques
- Ovarian cancer diagnosis and treatment
Nara Medical University
2015-2024
Shinko Hospital
2023-2024
National Archives and Records Administration
2023
National Hospital Organization
2023
Nara Medical University Hospital
2013-2022
Asahikawa Medical University
2021
Saiseikai Suita Hospital
2016
Kyoto Prefectural University of Medicine
2016
Kobe University
2005-2014
Kobe University Hospital
2001-2013
CT-Guided Transthoracic Needle Aspiration Biopsy of Small (≤ 20 mm) Solitary Pulmonary NodulesYoshiharu Ohno1, Hiroto Hatabu2, Daisuke Takenaka1, Takanori Higashino1, Hirokazu Watanabe1, Chiho Ohbayashi3 and Kazuro Sugimura1Audio Available | Share
Nectin-like molecule-5 (Necl-5) is an immunoglobulin (Ig)-like molecule that up-regulated in many types of cancer cells. It was shown experimentally Necl-5 enhances cell migration, proliferation, and metastasis, but its clinical significance has not been documented. The aim this study to observe the expression surgically resected primary lung adenocarcinomas investigate significance. A total 63 pulmonary adenocarcinoma tissues were investigated by immunohistochemistry for Necl-5....
PURPOSE: To evaluate short inversion time inversion-recovery (STIR) turbo spin-echo (TSE) magnetic resonance (MR) imaging for detection of metastases in lymph nodes by using quantitative and qualitative analyses. MATERIALS AND METHODS: One hundred ten patients (68 men 42 women) with non–small cell lung cancer who ranged age from 36 to 82 years (mean age, 64 years) were examined respiratory-triggered STIR TSE MR imaging. Ratios signal intensity a node that 0.9% saline phantom (lymph...
Abstract Purpose To conduct a prospective comparison of the accuracy short inversion time (TI) inversion‐recovery (STIR) turbo spin‐echo (SE) imaging and coregistered 2‐[fluorine‐18] fluoro‐2‐deoxy‐D‐glucose (FDG)–positron emission tomography (PET) with computed (CT) (coregistered FDG‐PET/CT) to assess N‐stage in non‐small‐cell lung cancer (NSCLC) patients. Materials Methods A total 115 consecutive NSCLC patients prospectively underwent CT, STIR SE imaging, FDG‐PET, as well surgical...
To estimate the phenotypic characterization of fibrotic process in adenomyosis occurring at inner or outer myometrium.Eight cases myometrium (Subtype I) and 10 II), normal counterparts were used this study. A immunohistochemical study for smooth muscle cells (SMCs) was performed using cytoskeletal proteins, Type I III collagen, TGF-β its signaling molecules.An increased expression collagen observed extracellular matrix adenomyotic foci. In uteri, immunostaining SMC differentiation marker...
Sleep apnea syndrome (SAS), characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia [IH]), is a risk factor for insulin resistance. Recently, IH considered to independently cause adipose tissue inflammation/dysfunction, leading worsening resistance; however, the detailed mechanism remains unknown. We exposed mouse 3T3-L1 human SW872 adipocytes experimental or normoxia 24 h, analyzed mRNA expression several adipokines. found that levels RETN, TNFα,...
The role of surgical treatment for malignant pleural mesothelioma (MPM) continues to be controversial. We carried out a retrospective review the prognosis in patients who had radical surgery MPM. Of 87 consecutive on whom exploration biopsy-proven MPM was performed, 31 underwent extrapleural pneumonectomy (EPP) and 34 pleurectomy/decortication (P/D). Sixty-five having EPP or P/D included 58 men (89%). median age 60 years (range 35-78) histologic type epithelial 48 (74%). IMIG staging...
Abstract Purpose To compare the nodule management capabilities of dynamic MRI, multidetector‐row computed tomography (MDCT) and coregistered positron emission (PET)/CT. Materials Methods Dynamic MDCT, PET, microbacterial, pathological examinations were administered to 175 consecutive patients with 202 nodules (<30 mm in diameter). The final diagnoses resulted classification into two groups: requiring further intervention treatment ( N = 163) no evaluation 39) groups. Maximum relative...
The pathophysiology of inflammatory bowel disease (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members have been reported to be expressed in Crohn's (CD) ulcerative colitis (UC) involved as proliferative factors IBD. However, expression all REG genes IBD is still unclear. Here, we analyzed (REG Iα, Iβ, III, HIP/PAP, IV) biopsy specimens UC CD by real-time RT-PCR. IV were overexpressed samples. was also We further the...
This real-world study examined the prevalence of programmed death ligand-1 (PD-L1) expression and assessed frequency microsatellite instability-high (MSI-H) status Epstein-Barr virus (EBV) positivity in Japanese patients with advanced gastric gastroesophageal junction (GEJ) adenocarcinoma. multicenter (5 sites), retrospective, observational (November 2018-March 2019) evaluated GEJ adenocarcinoma after surgical resection (Stage II/III at initial diagnosis) or unresectable cancer IV). The...
Abstract We retrospectively reviewed fine‐needle aspiration biopsy (FNAB) specimens of 301 soft tissue lesions the extremities and trunk. Final diagnoses were 137 benign 86 malignant neoplasms 78 nonneoplastic lesions. Of FNAB samples, 279 (93%) adequate for cytologic diagnosis. The initially grouped into three broad categories: (197 cases), (57 suspicious malignancy (25 cases). Sensitivity specificity diagnosis a lesion 92% 97%, respectively. cytomorphologically classified nine small round...
Sleep apnea syndrome is characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia [IH]) a risk factor for insulin resistance/type 2 diabetes. However, the mechanisms linking IH stress resistance remain elusive. We exposed human hepatocytes (JHH5, JHH7, HepG2) to experimental or normoxia 24 h, measured mRNA levels real-time reverse transcription polymerase chain reaction (RT-PCR), found that significantly increased selenoprotein P (SELENOP) —...
Genetic analysis on formalin‐fixed paraffin‐embedded (FFPE) tissue specimens has become a mainstream method, from conventional direct sequencing to comprehensive using next‐generation (NGS). In this study, we evaluated the quality of DNA and RNA extracted FFPE sections, derived surgical different tumor types. Electrophoresis was performed 4200 TapeStation evaluate fragmentation. Ct values were higher significantly increased over period 4 years compared with those cell lines or frozen...