A5082268022- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Trauma Management and Diagnosis
- RNA modifications and cancer
- Myasthenia Gravis and Thymoma
- Congenital Diaphragmatic Hernia Studies
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- DNA Repair Mechanisms
- Cardiac tumors and thrombi
- Sarcoma Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Pneumothorax, Barotrauma, Emphysema
- Medical Imaging Techniques and Applications
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Salivary Gland Tumors Diagnosis and Treatment
- Gut microbiota and health
- Protease and Inhibitor Mechanisms
Kobe University Hospital
2007-2025
Kobe University
2015-2024
Kobe Institute Of Computing
2021
Juntendo University
2021
Yokohama City University
2021
Kyoto University
2006
National Institutes of Health
2003
Memorial Sloan Kettering Cancer Center
2003
UNC Lineberger Comprehensive Cancer Center
2003
Akashi Medical Center
1994-1999
The human DNA damage sensors, Rad17-replication factor C (Rad17-RFC) and the Rad9-Rad1-Hus1 (9-1-1) checkpoint complex, are thought to be involved in early steps of response. Rad17-RFC 9-1-1 complex have been shown structurally similar replication factors, RFC clamp loader proliferating cell nuclear antigen polymerase clamp, respectively. Here, we demonstrate functional similarities between loader/DNA pairs. When all eight subunits two complexes coexpressed insect cells, a stable...
Nectin-like molecule-5 (Necl-5) is an immunoglobulin (Ig)-like molecule that up-regulated in many types of cancer cells. It was shown experimentally Necl-5 enhances cell migration, proliferation, and metastasis, but its clinical significance has not been documented. The aim this study to observe the expression surgically resected primary lung adenocarcinomas investigate significance. A total 63 pulmonary adenocarcinoma tissues were investigated by immunohistochemistry for Necl-5....
BACKGROUND The efficacy of postoperative radiotherapy (PORT) for thymic epithelial tumors is still controversial. Using the Japanese Association Research on Thymus (JART) database, this study was aimed at clarifying PORT Masaoka stage II and III carcinoma thymoma. METHODS JART database registered records 2835 patients collected from 32 institutions 1991 to 2010. Thymic thymoma or were extracted. with respect relapse‐free survival (RFS) overall (OS) evaluated Kaplan‐Meier method Cox...
To prospectively compare the capability of quantitative first-pass perfusion 320-detector row computed tomography (CT) (ie, area-detector CT) with that combined positron emission and CT (PET/CT) for differentiation between malignant benign pulmonary nodules.This prospective study was approved by institutional review board, written informed consent obtained from 50 consecutive patients 76 nodules. All underwent dynamic CT, PET/CT, microbacterial and/or histopathologic examinations. nodules...
The molecular etiology of idiopathic pulmonary fibrosis (IPF) has been extensively investigated to identify new therapeutic targets. Although anti-inflammatory treatments are not effective for patients with IPF, damaged alveolar epithelial cells play a critical role in lung fibrogenesis. Here, we establish an organoid-based model using mouse and human tissues assess the direct communication between type II (AT2)-lineage fibroblasts by excluding immune cells. Using this vitro genetics,...
The linkage of sister chromatids after DNA replication ensures the faithful inheritance chromosomes by daughter cells. In budding yeast, establishment chromatid cohesion requires Ctf8, Dcc1, and Ctf18, a homologue p140 subunit factor C (RFC). this report we demonstrate that in 293T cells, Flag-tagged Ctf18 forms seven-subunit cohesion-RFC complex comprised RFCp40, RFCp38, RFCp37, RFCp36 (Ctf18-RFC). We stoichiometric heteroheptameric Ctf18-RFC can be assembled coexpressing seven proteins...
Purpose To prospectively compare the diagnostic capability of short inversion time inversion-recovery (STIR) turbo spin-echo (SE) imaging, diffusion-weighted (DW) magnetic resonance (MR) and fluorodeoxyglucose (FDG) combined positron emission tomography (PET) computed (CT) in N stage assessment patients with non–small cell lung cancer (NSCLC). Materials Methods This prospective study was approved by institutional review board, written informed consent obtained from all patients. A total 250...
Abstract Purpose To compare the nodule management capabilities of dynamic MRI, multidetector‐row computed tomography (MDCT) and coregistered positron emission (PET)/CT. Materials Methods Dynamic MDCT, PET, microbacterial, pathological examinations were administered to 175 consecutive patients with 202 nodules (<30 mm in diameter). The final diagnoses resulted classification into two groups: requiring further intervention treatment ( N = 163) no evaluation 39) groups. Maximum relative...
The underlying mechanism why segmentectomy has demonstrated the non-inferiority to lobectomy in several randomized trials remains unclear. Computed tomography (CT)-measured pulmonary artery (PA) enlargement reflects PA pressure and predicts prognosis of certain respiratory diseases. We compared preoperative postoperative diameter ascending aorta (PA/A) ratio, investigating its impact on right ventricular function lung resection. This retrospective study was conducted patients with lower-lobe...
Abstract In the present study, we successfully generated lung cancer stem cell (CSC)-like cells by introducing a small set of transcription factors into line. addition to properties that are conventionally referred as CSC properties, induced CSCs exhibited ability form cancer-like tissues in vitro with vascular and mesenchymal cells, which showed structures immunohistological patterns were similar human tissues. We named them “lung organoids”. found interleukin-6 (IL-6), was expressed CSCs,...
We aimed to clarify the clinical features and surgical outcomes of descending necrotizing mediastinitis (DNM) provide a guide for its treatment, focusing on type extension deployed procedures.As joint study Japan Broncho-esophagological Society Japanese Association Chest Surgery (JBES1703/JACS1806 study), data consecutive patients with DNM who underwent drainage between 2012 2016 were collected from 131 participating institutions. The infection limited area superior carina level was defined...
DNA damage response pathways are important for maintaining genomic stability. The oncogenic phosphatase Wip1 plays a crucial role in by inhibiting several cell cycle proteins, including p53. Although gene amplification has been reported various primary tumors, lung cancer, its biological significance survival of tumor patients remains unclear. We investigated the expression cancer epithelial cells immunohistochemically 84 consecutive resected cases adenocarcinoma. Increased was observed 54...
The first influenza pandemic of the 21st century was caused by novel H1N1 viruses that emerged in early 2009. An Asp-to-Gly change at position 222 receptor-binding protein hemagglutinin (HA) correlates with more-severe infections humans. amino acid HA contributes to specificity Asp (typically found human viruses) and Gly avian classic swine viruses), conferring binding human- avian-type receptors, respectively. Here, we asked whether receptors enhances virus pathogenicity. We tested two 2009...