A5056127996- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Nutrition and Health in Aging
- Cancer Diagnosis and Treatment
- Renal and related cancers
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Abdominal vascular conditions and treatments
- Liver physiology and pathology
- Connective tissue disorders research
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Liver Disease and Transplantation
- Cancer Treatment and Pharmacology
- Colorectal Cancer Surgical Treatments
Nara Medical University
2016-2025
Johns Hopkins Medicine
2021-2023
Johns Hopkins University
2021-2023
Nara Medical University Hospital
2014-2019
Shigakkan University
1995
Jichi Medical University
1991
Jichi Medical University Hospital
1991
Kyushu University
1984-1989
Teikyo University
1987
Nippon Kayaku (Japan)
1984
Nectin-4 belongs to the nectin family that has diverse physiological and pathological functions in humans. Recent studies have also suggested some roles for several human cancers. However, precise clinical relevance of tumors are largely unknown.Nectin-4 expression was investigated 123 patients with pancreatic cancer by immunohistochemistry. Furthermore, we association tumor proliferation, angiogenesis immunity using immunohistochemistry siRNA interference method.Patients high had poorer...
Carbohydrate antigen (CA) 19–9 levels after resection are considered to predict prognosis; however, the significance of decreased CA19–9 neoadjuvant therapy has not been clarified. This study aimed define prognostic in patients with pancreatic adenocarcinoma. Between 2001 and 2012, 240 consecutive received subsequent at seven high-volume institutions Japan. These were divided into three groups: Normal group (no elevation [≤37 U/ml] before therapy), Responder (elevated [> 37 but afterwards),...
Patients with pancreatic ductal adenocarcinoma (PDAC) and liver metastasis are treated palliative chemotherapy, whereas similar patients metastatic colorectal cancer considered for aggressive surgery.
The optimal therapeutic strategy for very elderly pancreatic cancer patients remains to be determined. aim of this study was clarify the role resection in 80 years age or older.A retrospective multicenter analysis 1401 who had undergone performed. aged ≥ (n = 99) were compared with a control group <80 1302).There no significant differences postoperative complications and mortality between two groups. However, prognosis octogenarians poorer than that younger both resectable borderline tumors....
Three new phenolic compounds, 3'-Ο-methylsappanol, 3'-Ο-methylepisappanol and 3'-Ο-methylbrazilin, were isolated from Sappan Lignum, the dried heartwood of Caesalpinia sappan. The absolute configurations sappanol, episappanol, 3'-deoxysappanol, 3'-Ο-methylepisappanol, brazilin 3'-Ο-methylbrazilin determined by means Horeau's partial resolution method chemical correlations.Sappanol, 3'-Ο-methylsappanol form a novel class homoisoflavonoids.
Abstract Background Postoperative nonalcoholic fatty liver disease ( NAFLD ) after pancreaticoduodenectomy PD has recently become recognized. However, the pathoetiology of postoperative is largely unknown. Furthermore, optimal treatment not been established. The aim this prospective study was to clarify whether pancrelipase, which contains digestive pancreatic enzymes, could reverse . Methods A collaborative clinical trial conducted UMIN000006841 ). total 30 patients who developed were...
718 Background: Conversion surgery (CS) for unresectable locally advanced pancreatic cancer (UR-LAPC) has been widely accepted when feasible. However, optimal preoperative treatment strategies remain unclear. To determine the most effective approach UR-LAPC in current landscape, we conducted a project study Japanese Society of Hepato-Biliary-Pancreatic Surgery. Methods: We analyzed 465 patients who underwent CS following chemotherapy with FOLFIRINOX (FFX), gemcitabine plus nab-paclitaxel...
Management of gastrointestinal perforation in patients with vascular Ehlers-Danlos syndrome (vEDS) is clinically challenging. A male his 40s vEDS presented right lower abdominal pain. Computed tomography revealed a foreign body the ileum bowel perforation. detailed inquiry that he had consumed codfish six days prior. Based on these findings, was diagnosed small caused by fish bone. Emergency laparotomy performed and intraoperative findings showed bone penetrating mesentery. We resected ~5 cm...
Much attention has been paid to neoadjuvant treatment (NAT) as a new strategy especially for borderline resectable pancreatic cancer (BRPC). However, the optimal indication of NAT remains undetermined.We analyzed 248 patients with (PC). One hundred tumors were classified R group. Sixty-nine venous involvement BR-P group, while 31 arterial BR-A Ninety-nine received NAT. Furthermore, 48 unresectable locally advanced PC served controls (LAPC group). Among them, 11 adjuvant surgery afterwards...