A5101685684- Endometrial and Cervical Cancer Treatments
- Advanced Radiotherapy Techniques
- Management of metastatic bone disease
- Laser Applications in Dentistry and Medicine
- Head and Neck Cancer Studies
- Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Sports Analytics and Performance
- Prostate Cancer Treatment and Research
- Oral and Maxillofacial Pathology
- Ovarian cancer diagnosis and treatment
- Sports Performance and Training
- Lung Cancer Research Studies
- MRI in cancer diagnosis
- Prostate Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Spine and Intervertebral Disc Pathology
- CNS Lymphoma Diagnosis and Treatment
- Effects of Radiation Exposure
- Sports Dynamics and Biomechanics
- Telomeres, Telomerase, and Senescence
Tottori University Hospital
2022-2025
University of Tsukuba
2014-2024
Sumitomo Dainippon Pharma (Japan)
2014-2024
Japanese Red Cross Nagoya Daiichi Hospital
2022
Nara City Hospital
2022
Ohu University
2016-2021
Kobe University
2011-2020
Kobe Institute Of Computing
2020
UPMC Health System
2020
Duke Medical Center
2020
Abstract This study aimed to evaluate the efficacy of stereotactic body radiotherapy (SBRT) compared with three-dimensional conformal (3DCRT). Forty-three patients portal vein tumor thrombosis (PVTT)/inferior vena cava (IVCTT) treated SBRT (27 CyberKnife (CK) and 16 TrueBeam (TB)) from April 2013 December 2014, 54 3DCRT June 2008 March were evaluated. Dosimetric parameters, response (RT) survival outcomes in total vs. 3DCRT, CK TB respectively. The median biologically effective dose 10...
A long noncoding RNA (lncRNA), nuclear enriched abundant transcript 1 (NEAT1) variant (NEAT1v1), is involved in the maintenance of cancer stem cells (CSCs) hepatocellular carcinoma (HCC). CSCs are suggested to play important roles therapeutic resistance. Therefore, we investigated whether NEAT1v1 sensitivity radiation therapy HCC. Gene knockdown was performed using short hairpin RNAs, and NEAT1v1-overexpressing HCC cell lines were generated by stable transfection with a NEAT1v1-expressing...
To evaluate and compare the survivals radiotherapy-induced adverse events (AEs) of intensity-modulated radiotherapy (IMRT) with androgen deprivation therapy (ADT) trimodality therapy, including low-dose iodine-125 brachytherapy, external beam radiotherapy, ADT, for high-risk localized prostate cancer (LPC). High-risk patients LPC at T stage ≥ 3a, Gleason score 8, initial prostate-specific antigen 20.0 ng/mL treated between 2010 2021 were retrospectively evaluated. All IMRT plus ADT or...
The telomere hypothesis postulates stabilization of length and telomerase activation as key events in cellular immortalization carcinogeneses. Accordingly, has been suggested a novel highly selective target for design antitumor drugs. Screening chemical library including 16 000 synthetic compounds yielded six that strongly inhibited activity extracts cultured human cells, four isothiazolone derivatives two unrelated compounds. most potent inhibitor was...
The purpose of this study was to analyze outcomes for the treatment locally advanced temporal bone cancer by means concomitant chemoradiotherapy (CCRT) with a combination cisplatin (CDDP), 5-fluorouracil (5-FU), and docetaxel (TPF).Between 2006 2011, 34 patients squamous cell carcinoma were treated at Kobe University Hospital. Medical records retrospectively reviewed obtain information concerning patient characteristics, extent disease, treatment, adverse events, oncologic results.Ten CCRT...
Surgical spacer placement (SSP) is useful in particle therapy (PT) for patients with abdominal or pelvic tumors located adjacent to normal organs. We developed a nonwoven fabric bioabsorbable made of polyglycolic acid (PGA) sutures that degrades via hydrolysis. then conducted this first-in-human phase 1 study the combination SSP and PT using PGA spacer, which we termed space-making (SMPT). This aimed evaluate safety efficacy SMPT unresectable malignant tumor organs.The eligibility criteria...
In our previous study, monogalactosyl diacylglycerol (MGDG) purified from spinach was found to have cytotoxic effects in human cancer cell lines. This study further assessed whether MGDG can enhance the of radiation pancreatic cells vitro and vivo.Glycoglycerolipids including were extracted dried spinach. The cytotoxicity evaluated by MTT assay using four lines (MIAPaCa-2, AsPC-1, BxPC-3 PANC-1) normal dermal fibroblasts (NHDFs). alone or combination MIAPaCa-2 analyzed with colony forming...
Background and Purpose To investigate the prognostic value of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in patients with laryngeal cancer. Materials Methods The study included 51 whom 30 underwent definitive radiotherapy or without chemotherapy 21 radical surgery adjuvant chemoradiation therapy. FDG uptake by both primary lesion neck node was measured using maximum standardized (SUVmax). effects clinicopathological factors including tumor SUVmax nodal on progression-free...
Abstract Micro-slit-beam radiation therapy (MRT) using synchrotron-generated X-ray beams allows for extremely high-dose irradiation. However, the toxicity of MRT in central nervous system (CNS) use is still unknown. To gather baseline toxicological data, we evaluated mortality normal mice following CNS-targeted MRT. Male C57BL/6 J were head-fixed a stereotaxic frame. Synchrotron X-ray-beam was provided by SPring-8 BL28B2 beam-line. For MRT, delivered to groups 10 × 12 mm unidirectional array...
Organoids, self-organized cell aggregates, contribute significantly to developing disease models and cell-based therapies. Organoid-to-organoid variations, however, are inevitable despite the use of latest differentiation protocols. Here, we focused on morphology organoids formed in a cerebral organoid culture assessed their cellular compositions by single-cell RNA sequencing analysis. The data revealed that primarily composed non-neuronal cells, such as those from neural crest choroid...
To evaluate changes in the anterior and posterior corneal shape, thickness, chamber depth (ACD) caused by mydriasis or miosis using scanning-slit topography.Department of Ophthalmology, Iwate Medical University School Medicine, Iwate, Morioka, Japan.Twenty-eight eyes 28 healthy volunteers with refractive errors -6.00 to +0.25 diopters were studied. One eye each subject had instillation tropicamide-phenylephrine hydrochloride (Mydrin P) obtain pilocarpine 2% (Sanpilo) miosis. assess best-fit...
The aim of this study was to evaluate the significance nuclear factor-kappa B (NF-kappaB) expression as a marker radioresistance in early-stage laryngeal cancer.Thirty-five patients with local recurrence and 70 case-matched without were entered study. NF-kappaB compared Bcl-2 epidermal growth factor (EGF) receptor by immunohistochemistry, using pretreatment biopsy specimens. prognostic value also evaluated. Twenty-nine recurrent tumors tumors.NF-kappaB significantly correlated tumor control...
To examine the preliminary survival outcomes and treatment-related toxicity for elderly patients with cervical cancer treated radiotherapy (RT).Forty ≥75 years old who were RT evaluated. Of these 40 patients, 25 classified as FIGO stage I or II 15 III IVA. Thirty-five radical (RRT), five surgery plus adjuvant (S + ART). External beam combined high-dose-rate intracavitary brachytherapy was performed on 31 RRT 2 S ART because of positive vaginal surgical margins. The patients' median age 78...
Abstract Background The purpose of the present study was to analyze recurrence pattern high-grade glioma treated with a multimodal treatment approach and evaluate whether MIB-1 labeling index (LI) could be useful marker for predicting failure in glioblastoma (GB). Methods materials We evaluated histologically confirmed 131 patients either anaplastic astrocytoma (AA) or GB. A median dose 60 Gy. Concomitant adjuvant chemotherapy were administered 111 patients. LI assessed by...
The vasoconstrictive effect due to the addition of epinephrine local anesthetic has been clearly shown by measuring blood-flow volume or blood concentration in oral mucosal tissue. However, there are no reports on measurement using samples directly taken from jawbone and Consequently, this study, lidocaine tissue was considered quantitatively within Japanese white male rabbits ( n = 96) were used as test animals. General anesthesia induced sevoflurane oxygen, then cannulation femoral artery...