A5011126050- Neuroscience and Neuropharmacology Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Receptor Mechanisms and Signaling
- Reproductive Biology and Fertility
- Diatoms and Algae Research
- Nerve injury and regeneration
- Neurosurgical Procedures and Complications
- Skin Protection and Aging
- Hormonal Regulation and Hypertension
- Vascular Malformations Diagnosis and Treatment
- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Diet and metabolism studies
- Neural dynamics and brain function
- Renin-Angiotensin System Studies
- Liver Disease Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Neurogenesis and neuroplasticity mechanisms
- HER2/EGFR in Cancer Research
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Memory and Neural Mechanisms
The University of Tokyo
2024
KOSÉ (Japan)
2012-2020
Kone (Switzerland)
2008-2020
Aichi Human Service Center
2013-2019
University of Fukui
2019
Daiichi-Sankyo (Japan)
2005-2018
Canon (United States)
2017-2018
Nagoya City University
1983-2018
Wakayama Medical University
2016
Daiichi Sankyo (Germany)
2015
Brain-derived neurotrophic factor (BDNF) regulates both short-term synaptic functions and activity-dependent plasticity such as long-term potentiation. In the present study, we investigated role of BDNF in spatial reference working memory a radial arm maze test. The training resulted significant increase mRNA expression hippocampus, although frontal cortex did not change. When learning was inhibited by treatment with 7-nitroindazole, an inhibitor brain nitric oxide synthase, hippocampal...
ABSTRACT. Prevention or retardation of diabetic nephropathy (DN) includes anti-hypertensive treatment with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II type 1 receptor blockers (ARB) on the premises that these drugs have an added protective effect beyond their influence BP. The present study used a strain spontaneously hypertensive/NIH-corpulent rats [SHR/NDmc-cp (fat/fat)] as model DN to unravel renoprotective effects drugs. Olmesartan (1 5 mg/kg per d), ARB,...
The N-methyl-D-aspartate (NMDA) receptors are involved in long-term potentiation (LTP), and phosphorylated by several tyrosine kinases including a Src-family kinase Fyn. Brain-derived neurotrophic factor (BDNF) is neurotrophin, which also enhances hippocampal synaptic transmission efficacy increasing NMDA receptor activity. Here, we show that Fyn key molecule linking the BDNF TrkB with receptors, play an important role spatial memory formation radial arm maze. Spatial learning induced...
Tumor necrosis factor-α (TNF-α), a proinflammatory cytokine, is now emerging as an important modulator of the function CNS. Methamphetamine (METH) widely abused psychostimulant that causes euphoria, hyperactivity, and drug dependence. High doses METH cause long-term neurotoxicity in dopaminergic neurons. In this study, we investigated role TNF-α METH-induced dependence neurotoxicity. Repeated treatment with (2 mg/kg for 5 d) rats induced significant increase mRNA protein expression brain....
A series of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position their related compounds were prepared evaluated for antagonistic activities to angiotensin II (AII) receptor. Among them, 4-(1-hydroxyalkyl)imidazole derivatives had strong binding affinity AII receptor potently inhibited AII-induced pressor response by intravenous administration. Various esters these showed potent long-lasting activity oral The most promising...
Little is known about molecular mechanisms for long-lasting neuroadaptation related to the rewarding effects of methamphetamine (MAP). In present study, we examined intracellular signaling that associated with expression conditioned place preference (CPP) induced by MAP in rats. Rats were given or saline (control group) conditioning CPP test. MAP-treated and control animals killed immediately after test [CPP<sup>+</sup>]. Some rats without [CPP<sup>-</sup>]. Hyperphosphorylation...
Abstract Epidermal growth factor (EGF) is a member of structurally related family containing heparin‐binding EGF‐like (HB‐EGF) and transforming alpha (TGFα) that exerts neurotrophic activity on midbrain dopaminergic neurons. To examine abnormality in Parkinson's disease (PD), we measured the protein content EGF, TGFα, HB‐EGF post‐mortem brains patients with age‐matched control subjects. Protein levels EGF tyrosine hydroxylase were decreased prefrontal cortex striatum patients. In contrast,...
Background Neuregulin-1 (NRG1) is one of the susceptibility genes for schizophrenia and implicated in neurotrophic regulation GABAergic dopaminergic neurons, myelination, NMDA receptor function. Postmortem studies often indicate a pathologic association increased NRG1 expression or signaling with this illness. However, psychobehavioral implication has mainly been investigated using hypomorphic mutant mice individual splice variants. Methodology/Principal Findings To assess behavioral impact...
Amyloid β (Aβ)-induced neurotoxicity is a major pathological mechanism of Alzheimer's disease (AD). Our previous studies have demonstrated that schisandrin B (Sch B), an antioxidant lignan from Schisandra chinensis, could protect mouse brain against scopolamine- and cisplatin-induced neuronal dysfunction. In the present study, we examined protective effect Sch intracerebroventricular (ICV)-infused Aβ-induced dysfunction in rat cortex explored potential its action. results showed 26 days...
SPECIFIC AIMSIn this study, we investigated the hypothesis that a chronic intracerebroventricular (i.c.v.) infusion of amyloid β-peptide (Aβ) into rat can stimulate nitric oxide (NO) production, wh...
We analysed the expression of members hh gene family in adult ocular tissues newt, frog and mouse by RT‐PCR method. Shh displayed restricted neural retina that was conserved each species analyzed. X‐bhh , X‐chh Ihh were detected iris retinal pigment epithelium, while Dhh additionally faintly cornea. also found two types ptc genes, potential targets receptors, expressed these tissues, suggesting presence active signalling there.
Sekino, Yuko, Kunihiko Obata, Manabu Tanifuji, Makoto Mizuno, and Jin Murayama. Delayed signal propagation via CA2 in rat hippocampal slices revealed by optical recording. J. Neurophysiol. 78: 1662–1668, 1997. Signal from mossy fibers to CA1 neurons was investigated a combination of electrical recordings. The were prepared oblique sectioning the middle part hippocampus preserve fiber connections. stimulated induce population spikes (PSs) excitatory postsynaptic potentials region. Latencies...
MACRO Domain Containing 2 (MacroD2) is a neurodevelopmental disorder-related mono-ADP-ribosylhydrolase. Molecular features of this protein in neural tissues are largely unknown. In study, we generated specific antibody against MacroD2, and carried out expression morphological analyses the molecule during mouse brain development. Western blotting, MacroD2 isoforms with molecular masses ∼70 ∼75 kDa started to be expressed at embryonic day 16.5, reached maximal level postnatal 8, then gradually...
Abstract Serum hepatitis C virus (HCV) RNA level has been shown to be a good predictor of subsequent response interferon‐α (IFN) therapy in US patients whom genotype 1a/1b are both predominant. To determine whether serum HCV is IFN Japanese or not, appropriately collected pre‐IFN samples from 35 with chronic infection were studied. and determined correlated the IFN. Response was defined by alanine transaminase level: complete sustained (n = 15), followed relapse 10), no 10). Patients had...