A5061205086- Quantum, superfluid, helium dynamics
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Atomic and Subatomic Physics Research
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Physics of Superconductivity and Magnetism
- High-pressure geophysics and materials
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Pain Mechanisms and Treatments
- Superconducting Materials and Applications
- Nicotinic Acetylcholine Receptors Study
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Cold Atom Physics and Bose-Einstein Condensates
- Ion channel regulation and function
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Solid-state spectroscopy and crystallography
- Rare-earth and actinide compounds
- Attention Deficit Hyperactivity Disorder
- Surface and Thin Film Phenomena
- Neuroinflammation and Neurodegeneration Mechanisms
Meijo University
2014-2023
National Pension Service
2019
National Institute of Advanced Industrial Science and Technology
2014
Louisiana State University Health Sciences Center New Orleans
2009-2013
Ministry of Health Labour and Welfare
2012-2013
University of Chicago
2013
Nagoya University
1995-2004
Nagoya University Hospital
1996-2003
Material Sciences (United States)
1983
Cornell University
1983
A mouse model of Rubinstein—Taybi syndrome (RTS) was generated by an insertional mutation into the cyclic AMP response element-binding protein (CREB)-binding (CBP) gene. Heterozygous CBP-deficient mice, which had truncated CBP (residues 1–1084) containing CREB-binding domain 462–661), showed clinical features RTS, such as growth retardation (100%), retarded osseous maturation hypoplastic maxilla with narrow palate cardiac anomalies (15%) and skeletal abnormalities (7%). Truncated is...
Accumulated evidence suggests that oxidative stress is involved in amyloid beta (Abeta)-induced cognitive dysfunction. Silibinin (silybin), a flavonoid derived from the herb milk thistle (Silybum marianum), has been shown to have antioxidative properties; however, it remains unclear whether silibinin improves Abeta-induced neurotoxicity. In present study, we examined effect of on memory impairment and accumulation induced by Abeta(25-35) mice.Aggregated (3 nmol) was intracerebroventricularly...
Tumor necrosis factor-α (TNF-α), a proinflammatory cytokine, is now emerging as an important modulator of the function CNS. Methamphetamine (METH) widely abused psychostimulant that causes euphoria, hyperactivity, and drug dependence. High doses METH cause long-term neurotoxicity in dopaminergic neurons. In this study, we investigated role TNF-α METH-induced dependence neurotoxicity. Repeated treatment with (2 mg/kg for 5 d) rats induced significant increase mRNA protein expression brain....
Background : Midkine (MK) is a growth factor implicated in the development and repair of various tissues, especially neural tissues. However, its vivo function has not been clarified. Results Knockout mice lacking MK gene ( Mdk ) showed no gross abnormalities. We closely analysed postnatal brain (–/–) using calcium binding proteins as markers to distinguish neuronal subpopulations. Intense prolonged calretinin expression was found dentate gyrus granule cell layer hippocampus infant mice. In...
The ubiquitin–proteasome system (UPS) controls the stability of most cellular proteins. polymorphism UPS-related genes is associated with major depression disorder, but less known about molecule that plays a role in by modulating UPS. Melanoma antigen gene-D1 (MAGE-D1) interacts RING E3 ubiquitin ligase and implicated protein degradation. MAGE-D1 may thus play an important CNS via ubiquitylation. Here, we clarified novel emotional functions, namely its modulation ubiquitylation to serotonin...
Humanin is a very recently discovered 24 amino acid linear polypeptide, which protects against cell death induced by either familial Alzheimer's disease mutant of amyloid precursor protein, presenilin‐1 or presenilin‐2 in vitro . However, it has remained uncertain whether humanin useful drug for the animal model learning and memory deficit. In this study, we evaluated effects [Gly 14 ]‐humanin, more potent analogue, on scopolamine HBr (1 mg kg −1 s.c.)‐induced impairment spontaneous...
In Alzheimer's disease (AD), the deposition of amyloid peptides is invariably associated with oxidative stress and inflammatory responses. Silibinin (silybin), a flavonoid derived from herb milk thistle, has potent anti-inflammatory antioxidant activities. However, it remains unclear whether silibinin improves β (Aβ) peptide-induced neurotoxicity. this study, we examined effect on fear-conditioning memory deficits, response, induced by intracerebroventricular injection Aβ...
Abstract Depression is known to occur frequently in chronic hepatitis C viral (HCV) patients receiving interferon (IFN)-α therapy. In this study, we investigated whether indoleamine 2,3-dioxygenase1 (IDO1)-mediated tryptophan (TRP) metabolism plays a critical role depression occurring as side effect of IFN-α Increases serum kynurenine (KYN) and 3-hydroxykynurenine (3-HK) concentrations the ratios KYN/TRP 3-HK/kynurenic acid (KA) were much larger depressive HCV than non-depressed following...
We have previously demonstrated that continuous i.c.v. infusion of amyloid β‐peptide (Aβ), the major constituent senile plaques in brains patients with Alzheimer's disease, results learning and memory deficits rats. In present study, we investigated effects nefiracetam [N‐(2,6‐dimethylphenyl)‐2‐(2‐oxo‐1‐pyrrolidinyl) acetamide, DM‐9384] on Aβ‐(1–42)‐induced Aβ‐(1–42)‐infused rats, spontaneous alternation behaviour a Y‐maze task, spatial reference working water maze retention passive...
Accumulating evidence suggests that dysregulation of histone modification is involved in the pathogenesis and/or pathophysiology psychiatric disorders. However, abnormalities animal model schizophrenia and efficacy antipsychotics for such remain unclear. Here, we investigated involvement phencyclidine-induced behavioral effects on these abnormalities. After repeated phencyclidine (10 mg/kg) treatment 14 consecutive days, mice were treated with (clozapine or haloperidol) deacetylase inhibitor...
Abstract Telencephalin (TLCN) is a cell adhesion molecule selectively expressed in the telencephalon of mammalian brain. The mutant mice lacking TLCN had no detectable abnormalities their neural development and synaptic structures. Ablation increased hippocampal long‐term potentiation its saturation level. mutation enhanced performance radial maze water‐finding tasks, learning tasks with appetitive reinforcers, but not contextual fear conditioning Morris water aversive stimuli for...
Enriched environments (EEs) during development have been shown to influence adult behaviour. Environmental conditions childhood may contribute the onset and/or pathology of schizophrenia; however, it remains unclear whether EE might prevent schizophrenia. Herein, we investigated effects adolescence on phencyclidine (PCP)-induced abnormal behaviour, a proposed schizophrenic endophenotype. Male ICR mice (3 wk old) were exposed an for 4 and then treated with PCP 2 wk. The potentiated acute...