A5071854825- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Anesthesia and Neurotoxicity Research
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Neural dynamics and brain function
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Sexual Differentiation and Disorders
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Anesthesia and Sedative Agents
- Neuroscience and Neural Engineering
- Aortic Thrombus and Embolism
- Congenital Heart Disease Studies
- Neuropeptides and Animal Physiology
- Parkinson's Disease Mechanisms and Treatments
- Sperm and Testicular Function
- Sexual function and dysfunction studies
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Polyomavirus and related diseases
- Testicular diseases and treatments
- Coenzyme Q10 studies and effects
Tokyo Metropolitan Institute of Gerontology
2008-2023
Yamagata University
1993-2003
Fukushima Medical University
2003
Kobe City College of Nursing
2002
Hyogo Medical University
2002
Kubota (Japan)
2002
Kobe Gakuin University
2002
Kanazawa University
2000-2002
RIKEN Center for Brain Science
1999
The striatum, the input stage of basal ganglia, is a critical brain structure for learning stimulus-response habits as well motor, perceptual, and cognitive skills. Roles dopamine (DA) acetylcholine (ACh) in this form implicit memory have long been considered essential, but underlying cellular mechanism still unclear. By means patch-clamp recordings from corticostriatal slices mouse, we studied whether identified striatal cholinergic interneurons undergo long-term synaptic changes after...
Mutant Cu/Zn-superoxide dismutase (SOD1) protein aggregation has been suggested as responsible for amyotrophic lateral sclerosis (ALS), although the operative mediating factors are yet unestablished. To evaluate contribution of motoneuronal Ca2+-permeable (GluR2 subunit-lacking) alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors to SOD1-related death, we generated chat-GluR2 transgenic mice with significantly reduced Ca2+-permeability these in spinal...
The striatum is a heterogeneous mosaic of two neurochemically, developmentally, and functionally distinct compartments: the μ-opioid receptor (MOR)-enriched striosomes matrix. Preferential activation persistent suppression matrix have recently been suggested to represent neural correlates motor stereotypy. However, little known concerning physiological properties striosomes. We made patch-clamp recordings from medium spiny neurons in identified MOR-immunoreactive “dopamine islands” as slice...
A recent study has revealed that fear memory may be vulnerable following retrieval, and is then reconsolidated in a protein synthesis-dependent manner. However, little known about the molecular mechanisms of these processes. Activin βA, member TGF-β superfamily, increased activated neuronal circuits regulates dendritic spine morphology. To clarify role activin synaptic plasticity adult brain, we examined effect inhibiting or enhancing function on hippocampal long-term potentiation (LTP). We...
Dopamine D4 receptors (D4R) are localized in the globus pallidus (GP), but their function remains unknown. In contrast, dopamine D2 receptor activation hyperpolarizes medium spiny neurons projecting from striatum to GP and inhibits GABA release. However, using slice preparations D2R-deficient [D2 knock-out (D2KO)] mice, we found that inhibited GABA(A)-receptor-mediated currents neurons. The paired-pulse ratio was statistically unchanged after application significantly elevated D2KO wild-type...
Tyrosine hydroxylase (TH) is the initial and rate-limiting enzyme for biosynthesis of catecholamines that are considered to be involved in a variety neuropsychiatric functions. Here, we report behavioral neuropsychological deficits mice carrying single mutated allele TH gene which activity tissues reduced approximately 40% wild-type activity. In heterozygous mutation, noradrenaline accumulation brain regions was moderately decreased 73-80% value. Measurement extracellular level frontal...
Heterotromeric G-proteins of the Gq family are thought to transduce signals from group I metabotropic glutamate receptors (mGluRs) in central neurons. We investigated roles this cascade hippocampal long-term potentiation (LTP) by using null-mutant mice lacking alpha subunit (Galphaq) or G11 (Galpha11). found no obvious abnormalities morphology, layer structure, expression NMDA receptors, and basic parameters excitatory synaptic transmission hippocampus Galphaq mutant mice. used theta burst...
Epidemiological studies suggest the high fat content of Western diet to be responsible for atherosclerosis and its thrombotic complications. Despite such a prevailing view, few animal experiments have so far succeeded in demonstrating enhanced thrombogenicity due diet. Even very cholesterol (1%) has failed demonstrate an reaction rodents rabbits. The aim present study was twofold. First, we wanted establish new, sensitive specific vivo thrombosis model mice, which can then used effect diets....
Abstract The striatum harbors a small number of tyrosine hydroxylase (TH) mRNA‐containing GABAergic neurons that express TH immunoreactivity after dopamine depletion, some which reportedly resembled striatal medium spiny projection (MSNs). To clarify whether the mRNA‐expressing were subset MSNs, we characterized their postnatal development electrophysiological and morphological properties using transgenic mouse strain expressing enhanced green fluorescent protein (EGFP) under control rat...
We examined the function of presenilin‐1 (PS1) on neuronal resistance to oxidative stress. CNS neurons cultured from PS1‐deficient mice exhibited increased vulnerability H 2 O treatment compared with those wild‐type mice. Antioxidants protected against An intracellular calcium chelator, BAPTA AM, as well an L ‐type voltage‐dependent channel blocker, nifedipine, rescued ‐induced death, while N‐type ω‐conotoxin, or release blockers ER stores, dantrolene and xestospongin C, failed rescue them....
We previously reported increase in leucine-rich α2-glycoprotein (LRG) concentration cerebrospinal fluid is associated with cognitive decline humans. To investigate relationship between LRG expression the brain and memory impairment, we analyzed transgenic mice overexpressing (LRG-Tg) focusing on hippocampus. Immunostaining Western blotting revealed age-related hippocampal neurons 8-, 24-, 48-week-old controls LRG-Tg. Y-maze Morris water maze tests indicated retained spatial 8- 24-week-old...
Abstract The volatile anesthetic sevoflurane, which is widely used in pediatric surgery, has proposed effects on GABA A receptor‐mediated extrasynaptic tonic inhibition. In the developing striatum, medium‐sized spiny projection neurons have currents, function excitatory/inhibitory balance and maturation of striatal neural circuits. this study, we examined sevoflurane currents medium slices. Sevoflurane strongly increased conductance at postnatal days 3–35. antagonist transporter‐1,...