A5014064274- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Parkinson's Disease Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Memory and Neural Mechanisms
- Electrochemical sensors and biosensors
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
- Neurogenesis and neuroplasticity mechanisms
- Transcranial Magnetic Stimulation Studies
- Sleep and Wakefulness Research
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Attention Deficit Hyperactivity Disorder
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- Nicotinic Acetylcholine Receptors Study
- Cholinesterase and Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Electrochemical Analysis and Applications
- Tryptophan and brain disorders
University of Miyazaki
2001-2021
Hamamatsu University School of Medicine
2007-2021
Hamamatsu University
2005-2009
Ministry of Education, Culture, Sports, Science and Technology
2006
St. Marianna University School of Medicine
2003
Kobe University
2003
Niigata University
2001
Nagoya University
1987-1995
University of California, San Francisco
1994
University of Tsukuba
1994
N-Methylation of (R)-1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [(R)-salsolinol] derived from dopamine was proved by in vivo microdialysis study the rat brain. The striatum perfused with (R)-salsolinol and N-methylated compound identified dialysate using HPLC electrochemical detection multichanneled electrodes. confirmed three other regions brain, substantia nigra, hypothalamus, hippocampus. In amount significantly larger than regions. These results indicate that around...
Although prenatal stress has been repeatedly shown to inhibit adult neurogenesis in the dentate gyrus of offspring, its effects on embryonic and early postnatal brain development are not well described. Here, using cell proliferation marker 5-bromo-2'-deoxyuridine, we examine for first time effect at stage hippocampus, nucleus accumbens amygdala. We show that induces a significant decrease density 5-bromo-2'-deoxyuridine-positive cells (40%) hippocampus (60%), nonsignificant amygdala (30%)....
Tyrosine hydroxylase (TH) is the initial and rate-limiting enzyme for biosynthesis of catecholamines that are considered to be involved in a variety neuropsychiatric functions. Here, we report behavioral neuropsychological deficits mice carrying single mutated allele TH gene which activity tissues reduced approximately 40% wild-type activity. In heterozygous mutation, noradrenaline accumulation brain regions was moderately decreased 73-80% value. Measurement extracellular level frontal...
Abstract Many studies have demonstrated that physical or psychological stress can increase Fos expression in brainstem monoaminergic nuclei. Little is known, however, about the extent to which increases of and nonmonoaminergic neurons brainstem. We examined effects conditioned‐fear (CF) following mild footshock (FS) as unconditioned on GABAergic ventral tegmental area (VTA), locus coeruleus (LC), dorsal raphe nucleus (DR) rats. The CF significantly increased number Fos‐positive (Fos+) cells...
Background Brain synthesis of steroids including sex-steroids is attracting much attention. The endogenous corticosteroids in the hippocampus, however, has been doubted because inability to detect deoxycorticosterone (DOC) synthase, cytochrome P450(c21). Methodology/Principal Findings expression P450(c21) was demonstrated using mRNA analysis and immmunogold electron microscopic adult male rat hippocampus. DOC production from progesterone (PROG) by metabolism 3H-steroids. All enzymes required...
Evidence suggests that maternal stress during gestation in humans and animals can cause emotional cognitive dysfunction the offspring. In present study, we examined neurons of hippocampus medial prefrontal cortex adult rats exposed to prenatal stress. Using a revised Golgi–Cox staining method, found decreases dendritic length complexity area CA3 dentate gyrus male compared with controls, as well decreased prelimbic cortex. contrast, did not detect any changes dendrites female Our results...
Circadian melatonin secretion is the best-known output signal from circadian pacemaker in suprachiasmatic nucleus that indicates internal conditions of body. We have established a system enables long-term monitoring by implanting transverse microdialysis probe or near pineal gland freely moving mouse. This vivo method enabled continuous measurement over period >20 days individual CBA mice, with simultaneous recording locomotor activity. Pineal was completely matched to change activity, and...
Background Obstetric complications have been regarded as a risk factor for schizophrenia later in life. One of the mechanisms underlying association is postulated to be hypoxic process brain offspring around time birth. Hippocampus one regions implicated late-onset dopaminergic dysfunction associated with obstetric complications. Methodology/Principal Findings We used an animal model perinatal asphyxia, which rat pups were exposed 15 min intrauterine anoxia during Cesarean section At 6 and...
Abstract To clarify whether reelin signaling is involved in dopaminergic neurotransmission the adult mouse brain, we investigated dopamine function mice lacking (reeler). We found that methamphetamine‐induced locomotor activity significantly attenuated reeler mice. elucidate mechanism of this phenomenon, first presynaptic release; however, there were no significant differences wildtype, heterozygous and homozygous Next, examined response to intra‐accumbens injection D1 D2 receptor agonists,...
Although orexin-A peptide was recently found to inhibit the brain reward system, exact neural substrates for this phenomenon remain unclear. The aim of present study investigate role orexin neurons in intra-cranial self-stimulation behavior and clarify pathways through which inhibits system. Immunohistochemical examination using Fos, a neuronal activation marker, revealed that percentage activated cells very low lateral hypothalamus even hemisphere ipsilateral self-stimulation, suggesting...
In the developing cerebral cortex, marginal zone (MZ), consisting of early-generated neurons such as Cajal-Retzius cells, plays an important role in cell migration and lamination. There is accumulating evidence widespread excitatory neurotransmission mediated by γ-aminobutyric acid (GABA) MZ. cells express not only GABAA receptors but also α2/β subunits glycine receptors, exhibit receptor-mediated depolarization due to high [Cl(-)]i. However, physiological roles their endogenous agonists...