A5054470630- Maternal and fetal healthcare
- Neonatal Respiratory Health Research
- Cardiac Arrest and Resuscitation
- Congenital Diaphragmatic Hernia Studies
- Proteoglycans and glycosaminoglycans research
- Trauma and Emergency Care Studies
- Trauma Management and Diagnosis
- Pregnancy and preeclampsia studies
- Pediatric health and respiratory diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pregnancy-related medical research
- Anesthesia and Pain Management
- Reproductive Biology and Fertility
- Cell Adhesion Molecules Research
- Cardiac, Anesthesia and Surgical Outcomes
- Glycosylation and Glycoproteins Research
- Ectopic Pregnancy Diagnosis and Management
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Cellular Mechanics and Interactions
- Airway Management and Intubation Techniques
- Fetal and Pediatric Neurological Disorders
- Protease and Inhibitor Mechanisms
- Gestational Diabetes Research and Management
- Otitis Media and Relapsing Polychondritis
Yokohama City University
2023-2025
Saitama Medical University
2017-2024
Social Insurance Saitama Chuo Hospital
2018-2024
Jichi Medical University
2016-2017
Jichi Medical University Saitama Medical Center
2016-2017
Nagoya University
2000-2002
University of Washington
1964
Seattle University
1964
Neointima formation is a common feature of atherosclerosis and restenosis after balloon angioplasty. To find new target to suppress neointima formation, we investigated the possible role midkine (MK), heparin-binding growth factor with neurotrophic chemotactic activities, in formation. MK expression increased during caused by intraluminal injury rat carotid artery. model was strongly suppressed MK-deficient mice. Continuous administration protein mice restored Leukocyte recruitment vascular...
Background : Midkine (MK) is a growth factor implicated in the development and repair of various tissues, especially neural tissues. However, its vivo function has not been clarified. Results Knockout mice lacking MK gene ( Mdk ) showed no gross abnormalities. We closely analysed postnatal brain (–/–) using calcium binding proteins as markers to distinguish neuronal subpopulations. Intense prolonged calretinin expression was found dentate gyrus granule cell layer hippocampus infant mice. In...
Chondroitin 6-sulfotransferase (C6ST) catalyzes the transfer of sulfate to position 6 the<i>N</i>-acetylgalactosamine residue chondroitin. To obtain direct evidence regarding function C6ST and its product, chondroitin 6-sulfate, <i>in vivo</i>, we isolated mouse gene (<i>C6st</i>) generated mice deficient in this (<i>C6st<sup>−/−</sup></i>) by embryonic stem cell technology.<i>C6st<sup>−/−</sup></i> were born at approximately expected frequency viable through adulthood. In spleen...
Massive obstetric haemorrhage remains a major cause of maternal death attributable to hypofibrinogenaemia. Transfusion large volumes fresh frozen plasma (FFP) is required normalise fibrinogen levels. We compared the efficacy FFP (F group) with that plus concentrate + F in massive haemorrhage. In this retrospective study, we medical charts (2004-2016) 137 patients <150 mg/dl treated (n = 47; after August 2009) or 56; before 2009). Although was only administered severe cases, FFP/red blood...
Syndecan-4 is a transmembrane protein bearing heparan sulfate chains, involved in anticoagulation and focal adhesion formation. Here, we revealed that syndecan-4 was expressed the fetal vessels placental labyrinth by situ hybridization immunohistochemical staining. At 17.5 gestational days, area of degenerated more diffuse larger Synd4(-/-) embryos than wild-type controls. Calcium fibrin(ogen) depositions were also extensive severe placentas embryos. These findings suggest deficiency impairs...
A puerperal vulvovaginal hematoma may continue to grow after a surgical procedure and require blood transfusion. Thus, we selected arterial embolization for hemostasis as the first-line management in two cases of large hematoma.Case 1 was 32-year-old pregnant woman. After delivery, 10-cm vulvar developed. An enhanced computed tomography (CT) scan revealed active bleeding. Arterial performed complete obtained. Case 2 34-year-old woman with recurring delivery. CT extravasation hematoma....
In Japan, dilatation and curettage (D&C) is a common procedure for spontaneous miscarriage induced abortion, its safety has long been an issue. Electric vacuum aspiration (EVA) also common, but manual (MVA) was introduced recently, with medical abortions using mifepristone or misoprostol which are not yet legally accepted. This nationwide retrospective study surveyed the surgical methods complications associated abortion at less than 12 weeks of gestation in Japan to assess their safety,...
Abstract Background Determination of the optimal timing for termination pregnancy in cases preterm premature rupture membranes (pPROM) during extremely period is still difficult. Bronchopulmonary dysplasia (BPD) a major disease widely taken into account when determining prognosis respiratory disorders neonate. Many aspects this remain unclear. With aim further improving neonates born to mothers with pPROM, study examined who were diagnosed pPROM before 28 weeks gestation. The analysed risk...
A number of investigations have been made the estimation incidence central nervous system (CNS) malformations. Several these studies {e.g. McKeown and Record, Ciba Foundation, 1960) stressed association malformations (e.g. spina bifida with anencephalus or hydrocephalus). The possible effects birth order upon commented by several authors, but conclusions seem to vary according author. Thus Record (1949), on basis their examination 930 cases in Birmingham, considered that risk a CNS...
Abstract Aim Umbilical cord ulceration (UCU) is a disease in which an ulcer forms the umbilical pregnant uterus and accompanied by hemorrhaging from same site. UCU occurs fetuses with congenital upper‐intestinal atresia (CUIA); however, its onset mechanism remains unclear. Here, we report our investigation of cases hospital. Methods Among 9825 deliveries performed between 2007 2016 at this hospital, 20 were diagnosed CUIA, 4 (20%) had UCU. There was no difference backgrounds (UCU group:...
Little is known about the influence of pregnancy on pyogenic sterile arthritis, pyoderma gangrenosum, acne (PAPA) syndrome. We experienced a rare case complicated with PAPA The patient had various histories skin and joint disorders subarachnoid hemorrhage during pregnancy; however, her lesion was unaffected.
Mitochondrial disease exhibits various symptoms and is rarely seen in young women. We report the case of a patient with mitochondrial complicated maternal inherited diabetes-deafness (MIDD) who suffered severe clinical course. A 33-year-old primipara woman had history diabetes, diagnosed when she was 18 years old, treated insulin injection. At 24 genetic testing performed point mutation DNA m3243 identified. She admitted to our hospital at 23 weeks gestation because threatened preterm labor...
Instrument-assisted vaginal delivery is a significant risk factor for birth canal lacerations. Although many obstetricians recently are recommending restrictive rather than routine episiotomy, reports have shown episiotomy to be associated with more extensive anterior trauma compared episiotomy.We retrospectively reviewed 110 cases of forceps and vacuum deliveries investigated the site Birth lacerations were divided into four sites according direction-anterior, ipsilateral, contralateral,...
Abstract Background The U.S. Food and Drug Administration (FDA) European Medicines Agency (EMA) have published guidelines on the use of cancer treatments in young people reproductive potential. However, no such guideline is available Japan. Therefore, this project aimed to gather relevant data draft a respective guidance paper. Methods From April 2019 March 2021, Study Group for Providing Information Proper Use Pharmaceuticals Patients with Reproductive Potential at Japan Medical Research...
BACKGROUNDEarly recognition of hypofibrinogenemia and prompt initiation transfusion therapy in patients with massive obstetrical hemorrhage can improve prognosis. There are reports on the usefulness point-of-care testing, which provides quicker test results compared fibrinogen measurements using conventional Clauss method.OBJECTIVEThis study aimed to compare investigate diagnostic accuracy dry hematology thromboelastography testing for diagnosis hypofibrinogenemia.STUDY DESIGNA...
Background: The Japan Society of Obstetrics and Gynecology (JSOG) guidelines, revised in 2013, recommend that the numbers traction should be at most five repetitions vacuum extraction. Forceps extraction is less likely to fail compared with requires equipment preparation. At our institution, forceps delivery was not a standard procedure, but response revisions JSOG we launched an education program on for residents January 2013. We report results introduced institution.
Abstract Aim The high rate of stored preoperative autologous blood wastage is concerning. This study analyzed patients who provided donations (PABDs) for massive bleeding during surgery placenta previas and low‐lying placentas, investigated the optimal PABD storage volume required to avoid allogeneic transfusion. Methods Of 386 PABDs at our hospital from 2008 2013, 269 with or placentas were retrospectively analyzed. volumes stratified into four groups based on amounts stored, transfusion...