A5044154553- Vanadium and Halogenation Chemistry
- Metal complexes synthesis and properties
- Trace Elements in Health
- Cassava research and cyanide
- Neuroendocrine regulation and behavior
- Gut microbiota and health
- Tryptophan and brain disorders
- Vitamin K Research Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Birth, Development, and Health
- Mast cells and histamine
- Peroxisome Proliferator-Activated Receptors
- Metal-Organic Frameworks: Synthesis and Applications
- Animal Behavior and Welfare Studies
- Nuclear Receptors and Signaling
- Dialysis and Renal Disease Management
- Human-Animal Interaction Studies
- Metal-Catalyzed Oxygenation Mechanisms
- 3D IC and TSV technologies
- Drug-Induced Adverse Reactions
- Crystal structures of chemical compounds
- Veterinary Pharmacology and Anesthesia
- Electronic Packaging and Soldering Technologies
- Molecular Sensors and Ion Detection
- Water Quality Monitoring and Analysis
Kyoto University of Education
2020-2024
Japan Society for the Promotion of Science
2023-2024
Hokkaido University
2020
Meijo University
2015-2016
Osaka City University
2000-2005
Kobe Women's University
2005
Fuji Xerox (Japan)
2005
Keio University
1995
Abstract Zinc(II) complexes with a Zn(O4) coordination mode were found to have insulinomimetic activity. A bis-maltolato zinc(II) (Zn(Mal)2) complex was revealed be in an octahedral and square pyramidal geometries unit cell. Both Zn(Mal)2 (IC50 = 0.59 mM) bis-2-hydroxypyridine-N-oxide 0.41 exhibited higher activity than VOSO4(IC50 1.00 ZnSO4(IC50 0.81 terms of IC50 values, which show 50% inhibition concentration the free fatty acids release from rat adipocytes.
Zinc(II) complexes of alpha-amino acids and their derivatives with a Zn(N2O2) coordination mode were found to have in vitro insulinomimetic activity as estimated the inhibition free fatty acid release isolated rat adipocytes treated epinephrine. It was revealed that activities zinc(II) over-all stability constants (log beta) less than 10.5 are higher those ZnSO4 VOSO4. The high blood glucose level KK-Ay mice type 2 diabetes mellitus lowered by daily intraperitoneal injections complex,...
Executive function (EF) consists of explicit emotion regulation (EER) and cognitive control (CC). Childhood EER in particular predicts mental physical health adulthood. Identifying factors affecting development has implications for lifelong health. Gut microbiota (GM) attracted attention as a potential biomarker risk problems Furthermore, GM is related to brain function/structure, which plays crucial role emotional processing. However, little known about how compositions are associated with...
ABSTRACT Temperament is a key predictor of human mental health and cognitive emotional development. Although fear behavior reportedly associated with gut microbiome in infancy, infant microbiota changes dramatically during the first 5 years, when diversity composition are established. This period crucial for development prefrontal cortex, which involved emotion regulation. Therefore, this study investigated relationship between temperament 284 preschool children aged 3–4 years. Child was...
A novel bis(L-carnitinato)Zn(II) complex, Zn(car)2Cl2, was prepared, and its insulinomimetic antidiabetic activities were examined. The complex showed a tendency to lower the high blood glucose levels of KK-Ay mice with type 2 diabetes mellitus when given by oral administration at dose 20 mg Zn/kg body weight for 16 d. In addition, improved tolerance ability examined test (1 g glucose/kg weight).
Abstract Four Zn(II) complexes with dipeptides and three new pseudo-tripeptides were prepared a complex, [Zn(glythr)2]n, was revealed to have polymeric structure by X-ray analysis. The ligand, glythr−, acts as bridging ligand completely, monodentate oxygen atom of the terminal carboxyl group threonine residue didentate containing nitrogen atoms glycine one. Because Zn2+ ion has distorted six-coordinated octahedral geometry, it binds two groups ligands. Also, all found high in vitro...
Following the finding of in vitro insulinominetic activities new prepared Zn(II) complexes with amide ligands (2-picolinamide (pa-a) and 6-methyl-2-picolinmethylamide (6mpa-ma)) isolated rat adipocytes treated epinephrine terms inhibition free fatty acid release, their blood glucose normalizing effects were observed on daily intraperitoneal injections for 14 d a type 2 diabetes mellitus model animal, KK-Ay mice. The levels mice maintained normal range during administration both complexes....
In vitro insulinomimetic activities of Zn(II) complexes with three natural products, betaine, L-lactic acid, and D-(−)-quinic acid (qui), were found in rat adipocytes treated epinephrine terms the inhibition free fatty release. Based on results, blood glucose lowering effect KK-Ay mice type 2 diabetes mellitus was observed by daily i.p. injections a monomeric zinc(II) complex, Zn(qui)2, for 13 d.
We found alpha-glucosidase inhibitory effect of Zn(II) complex with 6-methyl-2-picolinmethylamide (6mpa-ma) which showed the highest blood glucose lowering in complexes picolinamide derivatives KK-A(y) mice. The strong activity greater by about eighty times (substrate: maltose) and forty sucrose) compared acarbose.
Histamine disappears rapidly from plasma because of its short half-life. Because a metabolite histamine, N-methylhistamine, is stable and has longer half-life, determination concentration can be useful in retrospective histamine release. In this study, we measured N-methylhistamine concentrations after d-tubocurarine (dTc) administration to evaluate the use measurement for confirming After induction anesthesia, five patients received dTc, 0.8 mg/kg intravenously. A radioimmunoassay kit was...
Abstract Three Zn(II) complexes with nicotinamide(na), nicotinemethylamide(nma), and nicotineethylamide(nea) were found to have in vitro insulinomimetic activities. X-ray structure analysis of [Zn(nea)2(H2O)2(SO4)]n showed that each nitrogen atom two nea molecules locates trans, the water oxygen sulfates coordinate a ion, forming an octahedral geometry Zn(N2O4) unit inorganic polymer crystal. The na, nma, exhibited higher activities, respective IC50 values (50% inhibition concentration...
Abstract A new zinc(II) complex, bis(6-ethylpicolinato)zinc(II) ([Zn(6epa)2]), was prepared by introducing an electron-donating ethyl group on the pyridine ring. [Zn(6epa)2] crystallized from aqueous solution, and its structure determined X-ray analysis, in which both carboxylate O N atoms of 6epa coordinated to a Zn2+ ion, forming distorted trigonal bipyramidal geometry with two water. In vitro evaluation regard inhibition free fatty acid (FFA) release isolated rat adipocytes presence...
Abstract Temperament is a key predictor of human mental health, and cognitive emotional development. While fear behavior reportedly associated with gut microbiome in infancy, infant microbiota changes dramatically during the first five years, when diversity composition are established. This period crucial for developing executive functioning, including emotion regulation. Therefore, this study investigated relationship between temperament 284 preschool children aged 3–4 years. Child was...
offspring such as attention deficit/hyperactivity disorder, learning disabilities, and persistent anxiety.
腹膜透析（peritoneal dialysis，以下PD）患者において残腎機能は予後と至適透析を行う上で重要である．シスタチンC（Cystatin C，以下CysC）はすべての有核細胞でほぼ一定の割合で産生され，糸球体から濾過されるため優れた糸球体濾過率（glomerular filtration rate，以下GFR）のマーカーとなりえる．今回，外来通院中の残腎機能を有するPD患者68人の延べ96血清において，血清CysC値が残腎機能の評価に有効か血清β2ミクログロブリン値（β2 microglobulin，以下β2MG）と比較検討した．血清CysC値と週当たりの腎Kt/Vurea（r＝－0.39，p＜0.0001），週当たりの腎クレアチニンクリアランス（creatinine...
Histamine disappears rapidly from plasma because of its short half-life. Because a metabolite histamine, N-methylhistamine, is stable and has longer half-life, determination concentration can be useful in retrospective histamine release. In this study, we measured N-methylhistamine concentrations after d-tubocurarine (dTc) administration to evaluate the use measurement for confirming After induction anesthesia, five patients received dTc, 0.8 mg/kg intravenously. A radio-immunoassay kit was...
LSI suppliers have been making strong efforts to introduce packages with lead free plating terminals. But, gull wing still use Sn-Pb plating. Many papers report that the combination of Sn-Ag-Cu solder paste and develops a low temperature layer on PWB copper pads causes pad peel-off in wave soldering process. This failure appears conspicuously case alloys containing Bi such as Sn-Zn-Bi Sn-Ag-In-Bi. paper examines composition limit using an EPMA (Electron Probe Micro Analyzer), simulation...