A5047078434- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Hip and Femur Fractures
- Knee injuries and reconstruction techniques
- Mesenchymal stem cell research
- Hip disorders and treatments
- Orthopedic Surgery and Rehabilitation
- Ultrasound and Hyperthermia Applications
- Tendon Structure and Treatment
- Pelvic and Acetabular Injuries
- Sports injuries and prevention
- Shoulder Injury and Treatment
- Bone Tissue Engineering Materials
- Bone health and osteoporosis research
- Sarcoma Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Bone health and treatments
- Shoulder and Clavicle Injuries
- Surgical site infection prevention
- Bone Metabolism and Diseases
- Venous Thromboembolism Diagnosis and Management
- Lower Extremity Biomechanics and Pathologies
Kobe University
2016-2025
Hyogo Prefectural Nishinomiya Hospital
2023-2025
Nihon University
2025
Himeji Medical Center
2024
Kobe Institute Of Computing
2021
Clinical Orthopaedics and Related Research
2020
Nanjing Drum Tower Hospital
2019
Pain and Rehabilitation Medicine
2018
Showa University
2018
Takatsuki General Hospital
2018
Introduction Surgical site infection is one of the most severe complications surgical treatments. However, optimal procedure to prevent such infections remains uninvestigated. Ultraviolet radiation C (UVC) with a short wavelength has high bactericidal effect; however, it cytotoxic. Nonetheless, given that UVC 222 nm reaches only stratum corneum, does not affect skin cells. This study aimed investigate safety 222-nm irradiation and examine its sterilization effect in healthy volunteers....
Although immobility is a common cause of muscle atrophy, the mechanism underlying this causality unclear. We here show that Krüppel-like factor 15 (KLF15) and IL-6 are upregulated in skeletal limb-immobilized mice with KLF15 deficiency or systemic protected from immobility-induced atrophy. A newly developed Ca2+ bioimaging revealed cytosolic concentration ([Ca2+]i) reduced to below basal level by immobilization, which associated downregulation Piezo1. Acute disruption Piezo1 induced Klf15...
Nonunion is a challenging problem that may occur following certain bone fractures. However, there has been little investigation of the molecular basis nonunions. Bone morphogenetic proteins (BMPs) play significant role in osteogenesis. known about expression patterns BMPs abnormal healing results nonunion formation. These facts prompted us to investigate and compare gene their antagonists standard fractures nonunions using rat experimental models. Standard closed atrophic produced by...
Background Carbon dioxide (CO2) therapy refers to the transcutaneous administration of CO2 for therapeutic purposes. This effect has been explained by an increase in pressure O2 tissues known as Bohr effect. However, there have no reports investigating oxygen dissociation haemoglobin (Hb) during application vivo. In this study, we investigate whether is caused human living body. Methods We used a novel system using pure gas, hydrogel, and plastic adaptor. The validity hydrogel was confirmed...
The discovery of microRNA (miRNA) has revealed a novel type regulatory control for gene expression. Increasing evidence suggests that miRNA regulates chondrocyte, osteoblast, and osteoclast differentiation function, indicating as key regulators bone formation, resorption, remodeling, repair. We hypothesized the functions certain miRNAs changes to their expression pattern may play crucial roles during process fracture healing. Standard healing fractures unhealing produced by periosteal...
Abstract Introduction Previous studies have reported that alignment changes depend on the patient’s position in orthopedic surgery. However, it has not yet been well examined how affects preoperative planning high-tibial osteotomy (HTO). Therefore, aim of this study was to investigate effects HTO. Materials and methods A total 60 knees 55 patients who underwent HTO were retrospectively examined. Virtual for medial open-wedge (OWHTO), lateral closed-wedge (CWHTO), hybrid CWHTO performed by...
Abstract Objective To investigate the role of transforming growth factor β (TGFβ)/bone morphogenetic protein (BMP) superfamily members on accumulation superficial zone (SZP) in articular chondrocytes and synoviocytes. Methods Chondrocytes synoviocytes were isolated from cartilage synovium calf stifle joints cultured as monolayers serum‐free chemically defined medium. Articular 3 distinct zones cartilage: superficial, middle, deep. Accumulation SZP culture medium response to various TGFβ/BMP...
Fracture-related infections are difficult to treat because of the formation biofilms around implants. Systemic antibiotics notoriously ineffective against due their insufficient penetration tissues with poor vascularity. The goal treating fracture-related is achieve bone union while retaining implant. Our proposal continuous local antibiotic perfusion a sustained delivery system sufficient and soft tissue infection sites, including marrow via needles as intra-medullary soft-tissue...
Superficial-zone protein (SZP), also known as lubricin, is a key mediator of boundary lubrication and plays an important role in the functional integrity diarthrodial joint. The aim this investigation was to examine transforming growth factor beta (TGF-beta) interleukin-1 (IL-1beta) on expression SZP various compartments bovine knee joint: superficial zone articular cartilage, synovium, meniscus, anterior posterior cruciate ligaments. effects TGF-beta1 IL-1beta were examined explants cells...
MicroRNAs (miRNAs ) are small non-coding RNAs that regulate gene expression. We hypothesised the functions of certain miRNAs and changes to their patterns expression may be crucial in pathogenesis nonunion. Healing fractures atrophic nonunions produced by periosteal cauterisation were created femora 94 rats, with 1:1 group allocation. At post-fracture days three, seven, ten, 14, 21 28, extracted from newly generated tissue at fracture site. Microarray real-time polymerase chain reaction...
Classification of femoral trochanteric fractures is usually based on plain X-ray findings using the Evans, Jensen, or AO/OTA classification. However, complications such as nonunion and cut out lag screw blade are seen even in stable fracture. This may be due to difficulty exact diagnosis fracture pattern X-ray. Computed tomography (CT) provide more information about pattern, but data scarce. In present study, it was performed propose a classification system for three-dimensional CT (3D-CT)...
The authors describe a tactile surgical navigation system using custom 3-dimensional (3D) models of the bony pelvis for complex acetabular fracture surgery. bone area interest was extracted from Digital Imaging and Communications in Medicine (DICOM) data computed tomography scans. A standard triangulated language file used to create 3D by layered manufacturing printer non-cytotoxic, sterilizable, acrylic-based photopolymers. No infections no toxic or other adverse events were observed....
Immobility is a common cause of muscle atrophy, but the underlying mechanisms have remained unclear. Here we show that limb immobilization in mice elicits inflammation and atrophy skeletal are preventable by neutralizing antibodies to chemokine CXCL10. Limb also induced changes gut microbiota intestinal inflammation, either sterilization intestine with antibiotics or administration 10-hydroxy-cis-12-octadecenoic acid-a linoleic acid-derived microbial metabolite-prevented as well...
Background/Objectives: The aim of this study was to evaluate changes in bone mineral density (BMD) around the stem elderly patients with femoral neck fractures who underwent hemiarthroplasty using a collared and full hydroxyapatite coated cementless stem, as assessed Dorr classification anti-osteoporosis drug intervention. Methods: This followed 85 older classified by Dorr’s classification. We measured their BMD dual-energy X-ray absorptiometry according Gruen 7 zones clinical scores....
Hypertrophic nonunion usually results from insufficient fracture stabilization. Therefore, most hypertrophic nonunions simply require the stabilization of site. However, reasons why union occurs without treating site directly is not well understood biologically. In this study, we hypothesized that intervening tissue at (nonunion tissue) could serve as a reservoir mesenchymal progenitor cells and investigated whether derived had capacity for multilineage differentiation. After was obtained,...
Abstract Most bone fractures typically heal, although a significant proportion (5%–10%) of fail to resulting in delayed union or persistent nonunion. Some preclinical evidence shows the therapeutic potential peripheral blood CD34+ cells, hematopoietic/endothelial progenitor cell-enriched population, for fracture healing; however, clinical outcome following transplantation cells patients with has never been reported. We report phase I/IIa trial regarding autologous, granulocyte colony...
The use of intramedullary nails to treat trochanteric fractures the femur has increased with increasing size elderly population. third generation Gamma nail is currently one most popular devices for treatment fractures. Nail breakage a rare complication, possibly resulting from fatigue fracture implant. We present first reported case that was not used pathological fracture. An 83-year-old woman an unstable treated using nail. She referred our hospital 14 months postoperatively at opening lag...