A5019226910- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Cerebrospinal fluid and hydrocephalus
- Parkinson's Disease Mechanisms and Treatments
- Atomic and Subatomic Physics Research
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological disorders and treatments
- Bone and Joint Diseases
- Medical Imaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Genetic Neurodegenerative Diseases
- Acute Ischemic Stroke Management
- Vascular Anomalies and Treatments
- Cell Image Analysis Techniques
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neonatal and fetal brain pathology
- Obstructive Sleep Apnea Research
- Seismic Imaging and Inversion Techniques
- Nuclear Physics and Applications
- NMR spectroscopy and applications
- Dementia and Cognitive Impairment Research
- Liver Disease Diagnosis and Treatment
- Neurological and metabolic disorders
Nagoya University
2019-2025
Nagoya City University
2014-2025
Keio University
2023
The University of Tokyo
2020-2023
Takeda (Japan)
2023
Boehringer Ingelheim (Japan)
2023
Nagoya City University Hospital
2011-2020
Toyokawa City Hospital
2020
Mizuho (Japan)
2014-2018
Kanazawa University
2011-2016
Abstract Objective Brain iron accumulation has been proposed as one of the pathomechanisms in Parkinson's disease (PD). This study aimed to examine whole‐brain pattern associated with cognitive impairment patients PD using voxel‐based quantitative susceptibility mapping analysis. Methods We enrolled 24 and mild impairment, 22 normal cognition, 20 age‐matched healthy controls this cross‐sectional study. All participants underwent global physical assessments brain MRI. Using a combined method...
Objective To examine the effect of apolipoprotein E ( APOE ) ɛ4 dose on blood–brain barrier (BBB) clearance function, evaluated using an advanced MRI technique and analyse its correlation with brain iron β-amyloid accumulation in early stages Alzheimer’s continuum. Methods In this single-centre observational prospective cohort study, 24 non-carriers, 22 heterozygotes 20 homozygotes continuum were scanned diffusion-prepared arterial spin labelling, which estimates water exchange rate across...
BACKGROUND: Combined quantitative susceptibility mapping and R2* relaxometry can distinguish iron myelin components in ischemic lesions. We aimed to investigate whether longitudinal changes magnetic values within lesions were associated with neurological outcomes. METHODS: In this single-center prospective study, we included patients, 20 90 years of age, who consecutively admitted the stroke care unit between August 2020 March 2022 due acute stroke. The participants underwent 2 instances...
The objective of this study was to assess the relationship between nigrostriatal magnetic susceptibility and dopamine transporter abnormality their associations with behavioral cognitive impairments in patients Parkinson's disease (PD).For case-control study, we enrolled 41 PD 20 age-matched healthy controls. All participants underwent global physical assessments, 3-Tesla brain resonance imaging including quantitative mapping (QSM; iron deposition measure), 123...
To separate the contributions of paramagnetic and diamagnetic sources within a voxel, magnetic susceptibility source separation method based solely on gradient-echo data has been developed. measure opposing more accurately, we propose novel single-orientation quantitative mapping with adaptive relaxometric constant estimation (QSM-ARCS) for separation. Moreover, susceptibilities their anisotropic effects were determined in healthy volunteers white matter. Multiple spoiled gradient echo...
To assess the relationship among iron accumulation, blood-brain barrier (BBB) damage, and cognitive function in patients with cerebral autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy (CADASIL).We enrolled 21 NOTCH3 mutations age-matched healthy controls this cross-sectional study. All participants underwent global physical assessments brain MRI using voxel-based quantitative susceptibility mapping (QSM; deposition measure) dynamic contrast-enhanced (BBB permeability...
Abstract Quantitative susceptibility mapping is a magnetic resonance imaging technique that measures brain tissues’ susceptibility, including iron deposition and myelination. This study examines the relationship between subcortical volume determines specific differences in these among patients with major depressive disorder (MDD), schizophrenia, healthy controls (HCs). was cross-sectional study. Sex- age- matched MDD ( n = 49), schizophrenia 24), HCs 50) were included. Magnetic conducted...
The purpose of this study was to assess the extent which improvement in sleep with lemborexant contributed changes interstitial fluid dynamics. 3 methods including diffusion tensor image analysis along perivascular space (DTI-ALPS), dynamic contrast-enhanced method tissue vascular permeability (Ktrans), and choroid plexus volume (CPV) were used. Correlations between these imaging indices parameters (latency persistent [LPS], wake after onset [WASO], total time [TST], efficiency [SE])...
Despite the fact that social anxiety disorder (SAD) is highly prevalent, there have been only a few structural imaging studies. Moreover, most of them reported about volume reduction in amygdale, which plays key role neural function SAD. Insula another region interest. Its hyperactivity regard to processing negative emotional information or interoceptive awareness has detected patients with Referring these studies, we hypothesized insular volumes might reduce SAD and made comparison between...
The oxygen extraction fraction (OEF) has been applied to identify ischemic penumbral tissue, but is difficult use in an urgent care setting. This study aimed investigate whether OEF map generated via magnetic resonance quantitative susceptibility mapping (QSM) could help the penumbra patients with acute stroke.This prospective imaging included 21 large anterior circulation vessel occlusion who were admitted <24 h after stroke onset and age-matched healthy controls. We identified as region a...
Abstract Background Mounting evidence suggests that the blood-brain barrier (BBB) plays an important role in regulation of brain iron homeostasis normal development, but these imaging profiles remain to be elucidated. We aimed establish a relationship between dynamics and BBB function during childhood using combined quantitative magnetic resonance (MRI) depict both physiological systems along developmental trajectories. Methods In this single-center prospective study, consecutive...
Recently, various prosthetic arms have been developed, but few are both attractive and functional. Considering human coexistence, must be safe flexible. In this research, we developed a novel arm with five-fingered hand using our original pneumatic actuators slender tendon-driven wrist wire drive two small motors. Because the hand's driving source is comprised of actuators, when it makes contact people; can also operate flexibly. addition, has to expand its motion space perform many...
This study aimed to develop and test a simultaneous acquisition analysis pipeline for voxel‐based magnetic susceptibility morphometry (VBMSM) on single dataset using young volunteers, elderly healthy an Alzheimer's disease (AD) group. 3D T 1 ‐weighted multi‐echo phase images VBM quantitative mapping (QSM) were simultaneously acquired magnetization‐prepared spoiled turbo multiple gradient echo sequence with inversion pulse QSM (MP‐QSM). The magnitude image was split into gray matter (GM)...
R2* relaxometry analysis combined with quantitative susceptibility mapping (QSM), which has high sensitivity to iron deposition, can distinguish microstructural changes of the white matter (WM) and thereby providing a sensitive biologically specific measure WM owing in myelin its surrounding environment. This study aimed explore alterations associated cognitive impairment patients Parkinson's disease (PD) using QSM. We enrolled 24 PD mild (PD-MCI), 22 normal cognition (PD-CN), 19 age-...
Due to clinicoradiological similarities, including amnestic cognitive impairment and limbic atrophy, differentiation of argyrophilic grain disease (AGD) from Alzheimer's (AD) is often challenging. Minimally invasive biomarkers, especially magnetic resonance imaging (MRI), are valuable in routine clinical practice. Although it necessary explore radiological clues, morphometry analyses using new automated analytical methods, whole-brain voxel-based (VBM) surface-based (SBM), have not been...
Purpose To determine whether temporal changes in apparent diffusion coefficient (ADC) over the cardiac cycle are different patients with idiopathic normal-pressure hydrocephalus (INPH) as compared ex vacuo ventricular dilatation and healthy control subjects. Materials Methods This prospective study was approved by institutional review board performed only after informed consent obtained from each patient. At 1.5 T, electrocardiographically triggered single-shot echo-planar magnetic resonance...
Rapid eye movement sleep behavior disorder is parasomnia characterized by symptoms of dream enactment and loss muscle atonia during rapid sleep. Mild motor impairment present in some patients with presumed to be a risk factor for conversion synucleinopathies. The purpose this study identify mild evaluating finger tapping investigate its pathophysiology. Twenty-three 20 healthy control subjects were recruited the study. We accurately evaluated including amplitude, peak open, close speed...
Abstract Background Mild cognitive impairment in Parkinson’s disease (PD-MCI) is associated with an increased risk of decline. PD-MCI characterized by impairments executive function and visuospatial recognition. The n-back test useful for assessing both domains. 0-back reflects recognition, while the 1-back 2-back tests reflect working memory. Cholinesterase inhibitors are effective treatment dementia PD (PDD). Although some studies have reported efficacy memantine PDD, therapeutic patients...