A5030352704- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Venous Sinus Thrombosis
- Spinal Dysraphism and Malformations
- Advanced Neuroimaging Techniques and Applications
- Vestibular and auditory disorders
- Facial Nerve Paralysis Treatment and Research
- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Hearing, Cochlea, Tinnitus, Genetics
- Radiomics and Machine Learning in Medical Imaging
- Cell Image Analysis Techniques
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Pancreatitis Pathology and Treatment
- Brain Tumor Detection and Classification
- Meningioma and schwannoma management
- Pancreatic and Hepatic Oncology Research
- Neurosurgical Procedures and Complications
- Head and Neck Surgical Oncology
- EEG and Brain-Computer Interfaces
- Central Venous Catheters and Hemodialysis
- Medical Image Segmentation Techniques
- Ear Surgery and Otitis Media
Nagoya University
2013-2025
Japanese Red Cross Nagoya Daiichi Hospital
2014
The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was developed to evaluate brain's glymphatic function or interstitial fluid dynamics. This study aimed reproducibility of DTI-ALPS and effect modifications in imaging data evaluation.Seven healthy volunteers were enrolled this study. Image acquisition performed for test-retest using a fixed sequence modified methods which included placement region interest (ROI), plane, head position, averaging, number...
More than 5 years have passed since the Diffusion Tensor Image Analysis ALong Perivascular Space (DTI-ALPS) method was proposed with intention of evaluating glymphatic system. This is handy due to its noninvasiveness, provision a simple index in straightforward formula, and possibility retrospective analysis. Therefore, ALPS adopted evaluate system for many disorders studies. The purpose this review look back discuss at moment.
The purpose of this study was to evaluate the interstitial fluid status in a wide range age groups using diffusion-weighted image analysis along perivascular space (DWI-ALPS) method, which is simplified variation diffusion tensor (DTI-ALPS).This retrospective included data from 128 patients who underwent clinical magnetic resonance imaging (MRI) studies, including DWI, and were found have no abnormal findings brain on MRI. Three motion-probing gradients DWI applied an orthogonal direction...
Purpose: Many inner ear disorders, including Ménière's disease, are believed to be based on endolymphatic hydrops. We evaluated a newly proposed method for semi-quantification of size in patients with suspected hydrops that uses 2 kinds processed magnetic resonance (MR) images. Methods: Twenty-four consecutive underwent heavily T2-weighted (hT2W) MR cisternography (MRC), hT2W 3-dimensional (3D) fluid-attenuated inversion recovery (FLAIR) time 2250 ms (positive perilymph image, PPI), and...
The purpose of this study was to assess the extent which improvement in sleep with lemborexant contributed changes interstitial fluid dynamics. 3 methods including diffusion tensor image analysis along perivascular space (DTI-ALPS), dynamic contrast-enhanced method tissue vascular permeability (Ktrans), and choroid plexus volume (CPV) were used. Correlations between these imaging indices parameters (latency persistent [LPS], wake after onset [WASO], total time [TST], efficiency [SE])...
Interest in interstitial fluid dynamics has increased since the proposal of glymphatic system hypothesis. Abnormal have been pointed out to be an important factor various pathological statuses. In this article, we propose concept central nervous fluidopathy as a disease or condition which abnormal is one factors for development condition. We discuss aspects diseases, including Alzheimer's disease, Parkinson's normal pressure hydrocephalus, and cerebral small vessel disease. also method...
Purpose: MRI of endolymphatic hydrops (EH) 4 h after intravenous administration a single dose gadolinium-based contrast agent is used for clinical examination in some institutions; however, further improvement image quality would be valuable wider utility. Denoising using deep learning reconstruction (Advanced Intelligent Clear-IQ Engine [AiCE]) has been reported CT and MR. The purpose this study was to compare the contrast-to-noise ratio endolymph perilymph (CNREP) between improved hybrid...
Abstract Purpose To visualize and analyze the dynamics of cerebrospinal fluid (CSF) motion in cranium, we evaluated distribution motion-related signal dephasing by CSF on Diffusion ANalysis DYnamics with Incremental Strength Motion proving gradient (DANDYISM) method, a composite imaging method using various low b values. Materials methods This study examined ten subjects aged 25–58. We acquired DWIs 3T clinical scanner values 0, 50, 100, 200, 300, 500, 700, 1000 s/mm 2 total time 4 min....
We explored normal diameter values of the cochlear (CN) and facial (FN) nerves on 3-dimensional constructive interference in steady state (3D-CISS) using a 3-tesla magnetic resonance (MR) imaging scanner.A total 142 patients underwent MR inner ear at 3T. retrospectively analyzed data from 172 ears. All ears had hearing no history ipsilateral palsy. Parasagittal images 0.5-mm thickness perpendicular to internal auditory canal were reconstructed 0.4-mm thick axial 3D-CISS for all Two...
Purpose: The purpose of this retrospective study was to investigate the relationship between number and size cystic structures around cortical veins near superior sagittal sinus leakage gadolinium-based contrast agent (GBCA) veins.
Abstract In the current study, we assessed changes in interstitial fluid dynamics resulting after whole‐brain radiotherapy using diffusion‐weighted image analysis along perivascular space (DWI‐ALPS) method, which is a simplified variation of diffusion tensor ALPS (DTI‐ALPS) method imaging (DWI) with orthogonal motion‐probing gradients (MPGs). This retrospective study included 47 sets from 22 patients who underwent for brain tumors. The data normal control group comprised 105 participants no...
To investigate the association between signal changes over time in perivenous cystic structures near superior sagittal sinus and leakage of a gadolinium-based contrast agent (GBCA) into subarachnoid space patients with suspected endolymphatic hydrops.Fifty-one 27 cases were evaluated. The intensity was measured on 3D real inversion recovery (3D-real IR) images obtained at pre-, 10 min, 4 hrs 24 post-intravenous administration (IV) GBCA. Signal enhancement from pre-contrast each point...
Decrease in signal of the cerebrospinal fluid (CSF) on low b-value diffusion weighted image (DWI) due to non-uniform flow can provide additional information regarding CSF motion. The purpose current study was evaluate whether arterial pulsations constitute driving force motion.We evaluated signals within Sylvian fissure DWI 19 patients with unilateral middle cerebral artery (MCA) occlusion. 500 s/mm2 for a decrease including vallecula and lower, middle, higher fissures graded as follows:...
To identify magnetic resonance cisternography (MRC) imaging findings related to Gadolinium-based contrast agent (GBCA) leakage into the subarachnoid space.The number of voxels GBCA (V-leak) on 3D-real inversion recovery images was measured in 56 patients scanned 4 h post-intravenous injection. Bridging veins (BVs) were identified MRC. The numbers BVs with surrounding cystic structures (BV-cyst), arachnoid granulations protruding superior sagittal sinus (BV-AG-SSS) and skull (BV-AG-skull),...
We report here a rare case of undifferentiated carcinoma the pancreas mimicking main-duct intraductal papillary mucinous neoplasm. In an 80-year-old woman, approximately 8-mm mass was incidentally detected at downstream edge dilatated main pancreatic duct lumen on CT and MRI. Main dilatation in body tail parenchymal atrophy were observed upstream mass. Histopathologically, tumor protruded into body. The cells had highly atypical nuclei abundant polymorphic structures, showed positive...
Abstract Purpose The diploic veins have been suggested to be involved in the excretion of cerebrospinal fluid and intracranial waste products; however, date, there no reports evaluating space surrounding veins. Therefore, we aimed visualize distribution gadolinium-based contrast agent (GBCA) evaluate spatial characteristics. Materials methods Ninety-eight participants (aged 14–84 years) were scanned 4 h after intravenous GBCA injection at Nagoya University Hospital between April 2021...
The characteristics of tissue structures can be estimated by comparing images with different diffusion times acquired using the OGSE and PGSE methods. However, for multiple images, it is difficult to make pixel-by-pixel comparison. We attempted a method integrating pixel values these ternary plotting malignant glioma cases. Tumor areas abnormal enhancement, peritumoral signal areas, distant edematous were evaluated. plot provided immediate visual information. It also highlighted similarities...
Motivation: The motivation is to investigate the relationship between sleep and interstitial fluid dynamics influenced by administration of lemborexant, a dual orexin receptor antagonist. Goal(s): goal identify changes in indices related before after lemborexant. Approach: ALPS-index, Ktrans DSC method, choroid plexus volume were assessed as indicators dynamics. Results: indexes on night found correlate with ALPS-index measured evening that night's sleep. In multiple regression analysis, was...
Motivation: The edema around a malignant glioma contains infiltrating tumor cells. motivation for this study was to determine the characteristics of glioma. Goal(s): goal is evaluate gliomas using combination oscillating gradient spin echo and pulsed echo. Approach: ternary plot method used by existing tissue as an internal reference. Results: Edema showed different distribution in relation reference compared other tumors. Impact: Ternary present pixel values obtained from echo, tissues were...
The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method has been developed to evaluate glymphatic function. In order wider clinical cases, we a weighted ALPS (DWI-ALPS) technique. ALPS-index was retrospectively calculated by DWI of normal subjects and those with pathologies. subjects, highest in their forties lowest seventies. Patients Alzheimer’s disease subdural hematoma showed lower than age-matched subjects. DWI-ALPS seems be feasible for evaluation...