A5040602190- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Tryptophan and brain disorders
- Dementia and Cognitive Impairment Research
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Neurological disorders and treatments
- Advanced NMR Techniques and Applications
- Neural and Behavioral Psychology Studies
- Pain Management and Treatment
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Music Perception
- Intensive Care Unit Cognitive Disorders
- Cell Image Analysis Techniques
- Metabolism and Genetic Disorders
- Acute Ischemic Stroke Management
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience and Neural Engineering
Keio University
2018-2025
Yokohama City University
2024
Keio University Hospital
2019-2024
Centre for Addiction and Mental Health
2022-2023
Jikei University School of Medicine
2023
The University of Tokyo
2022-2023
Takeda (Japan)
2023
Boehringer Ingelheim (Japan)
2023
Nagoya University
2023
The University of Melbourne
2023
Abstract Quantitative susceptibility mapping is a magnetic resonance imaging technique that measures brain tissues’ susceptibility, including iron deposition and myelination. This study examines the relationship between subcortical volume determines specific differences in these among patients with major depressive disorder (MDD), schizophrenia, healthy controls (HCs). was cross-sectional study. Sex- age- matched MDD ( n = 49), schizophrenia 24), HCs 50) were included. Magnetic conducted...
Abstract Background Neuromelanin (NM) is a byproduct of monoamine metabolism, including that dopamine. NM-sensitive Magnetic Resonance Imaging (NM-MRI) sequences enable the in vivo quantification NM levels substantia nigra (SN). The NM-MRI signal considered surrogate marker for integrity SN dopamine neurons and, consequently, striatal dopaminergic functioning. Elevated synthesis associated with patients responsive to first-line antipsychotics (FLR) schizophrenia, while normal implicated...
Abstract Background Chronic heavy alcohol consumption is known to harm health, while occasional light moderate drinking may have potential benefits. However, it unclear how modest intake affects brain structure. Aims & Objectives This study aimed examine the white matter integrity changes after a dose of acute using diffusion tensor imaging (DTI). Method Healthy individuals aged between 20 and 29, with ALDH2*1/*2 genotype, who understood gave written informed consent were included in...
Abstract Background Functional connectivity density, both local (lFCD) and global (gFCD), derived from functional magnetic resonance imaging (fMRI) delineates the prominence of regional widespread hubs throughout brain. However, it remains unknown regarding neurobiological mechanism hubness lFCD gFCD. α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor regulates most excitatory signals as a main controller activities relating to in We hypothesized that there was positive...
Abstract Background Treatment-resistant depression (TRD) is associated with gray matter volume reduction compared to healthy controls (HC). Since has increasingly been recognized as a disorder of dysregulated neural networks, it important evaluate these structural changes in terms brain networks. Structural covariance measurement that gauges the association strength measures between two regions, which used examine network-level alteration structure. Although several studies reported abnormal...
Abstract Background Progressive abnormalities in brain structures have consistently been reported depression. However, the distinct trajectories of progressive structural TRD remain unknown. Moreover, treatment-resistant depression (TRD) is suggested to a heterogeneous pathophysiology. The Subtype and Stage Inference (SuStaIn) algorithm, an unsupervised machine learning technique, has shown premise distinguishing disease biotypes with different progression trajectories. Aims & Objectives...
Abstract Background Approximately 30% of patients with schizophrenia (SZ) do not respond to antipsychotic treatment. Although abnormalities the dopamine (DA) function are implicated in pathophysiology SZ, reports on striatal DA and treatment responsiveness inconsistent.The striatum is modified by released from substantia nigra (SN). Neuromelanin (NM) a product monoamine metabolism including DA. NM-sensitive MRI sequences allow vivo quantification NM levels SN. NM-MRI signal thought serve as...
Abstract Background Treatment-resistant depression (TRD) is a highly biologically heterogeneous disorder, which may be due to underlying neuroanatomical heterogeneity. However, neuroimaging studies date have not yielded consistent results, possibly in part lack of analytical approaches that account for clinicodemographic confounds. The heterogeneity through discriminative analysis (HYDRA) method (Varol et al. 2017) takes into clinical confounding factors and enables biotyping based on...
Abstract Background Given the heterogeneity, particularly in terms of treatment response, and possible disease progression schizophrenia, identifying neurobiological subtypes patterns each patient may lead to novel biomarkers. Treatment-resistant schizophrenia (TRS) is a distinct subpopulation showing poor response conventional pharmacological and, as result, form illness associated with serious social economic burden. The basis TRS remains be elucidated, despite numerous strategies...
Background:Cognitive reserve is the acquired capacity reflecting a functional brain adaptability/flexibility in context of aging. Educational attainment thought to be among most important factors that contribute cognitive reserve. Objective:The aim this study investigate relationships duration education and Alzheimer's disease (AD) related neuroimaging biomarkers such as amyloid-β deposition, glucose metabolism, volumes each stage AD. Methods:We reanalyzed part datasets Disease Neuroimaging...