A5071644562- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Hydrogen Storage and Materials
- Substance Abuse Treatment and Outcomes
- Mental Health Research Topics
- Advanced Chemical Physics Studies
- Anesthesia and Neurotoxicity Research
- Mental Health Treatment and Access
- Diet and metabolism studies
- Catalytic Processes in Materials Science
- Community Health and Development
- Homelessness and Social Issues
- Nuclear Materials and Properties
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Epilepsy research and treatment
- Ammonia Synthesis and Nitrogen Reduction
- Impact of Technology on Adolescents
- Gambling Behavior and Treatments
- Mindfulness and Compassion Interventions
- Bipolar Disorder and Treatment
- Adenosine and Purinergic Signaling
- Fusion materials and technologies
- Alcohol Consumption and Health Effects
Keio University
2023-2025
Zero to Three
2024
Tokai University
1991
Abstract Background Stigma hinders the recovery from mental disorders due to societal statuses, social networks, and patients' pride. Self-stigma particularly internalizes fear of standing out, leading patients experience self-blame, despair, shame associated with their disorders. Patients alcohol use face self-stigma lack acceptance for such conditions. Yoga is a mind-body exercise intervention that has gained popularity over last decade. Previous randomized controlled trials (RCTs)...
Abstract Background Functional connectivity density, both local (lFCD) and global (gFCD), derived from functional magnetic resonance imaging (fMRI) delineates the prominence of regional widespread hubs throughout brain. However, it remains unknown regarding neurobiological mechanism hubness lFCD gFCD. α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor regulates most excitatory signals as a main controller activities relating to in We hypothesized that there was positive...
Abstract Background Whereas ketamine has displayed robust antidepressant effects in treatment-resistant depression (TRD) (Han et al., 2016), only 30-40% of patients with TRD respond to therapy (Wilkinson 2018; Sakurai 2020). Several postmortem studies have shown decreased myelination (Hamidi, Drevets and Price, 2004; Altshuler 2010), an animal study suggested that increased may underlie the for (Huang 2023). Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging technique...
Abstract Background Whereas ketamine's antidepressant effect for treatment-resistant depression (TRD) has been consistent in the literature from North American and European countries (1-3), its evidence is scarce among Asian population (4-6). Aims & Objectives We aimed to evaluate efficacy safety of intravenous ketamine treatment Japanese patients with TRD. Method In this double-blind randomized placebo-controlled trial, 34 (41.4±9.4 years, 23 men [67.6%]) TRD were receive either (0.5...
Abstract Synaptic phenotypes in living patients with psychiatric disorders are poorly characterized. Excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) is a fundamental component for neurotransmission. We recently developed positron emission tomography (PET) tracer AMPAR, [ 11 C]K-2, the first technology to visualize and quantify AMPARs density human brain. In this study, we characterized major C]K-2. One hundred forty-nine (schizophrenia, n = 42;...
Abstract Introduction Predictors of treatment response to intravenous ketamine remain unclear in patients with treatment-resistant depression (TRD); therefore, this study aimed clarify these predictors using the US National Institutes Health database clinical trials. Methods Data from a placebo-controlled, double-blind, randomized controlled trial were used assess efficacy adult TRD (NCT01920555). For analysis, data participants who had received therapeutic doses (i. e., 0.5 and 1.0 mg/kg)....
Although the antidepressant effect of ketamine on treatment-resistant depression (TRD) has been frequently reported in North American and European countries, evidence is scarce among Asian population. We aimed to evaluate efficacy safety intravenous Japanese patients with TRD.