A5026307364- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Substance Abuse Treatment and Outcomes
- Neuroscience and Neuropharmacology Research
- Alcohol Consumption and Health Effects
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Pharmacological Receptor Mechanisms and Effects
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Cerebrovascular and Carotid Artery Diseases
- Tryptophan and brain disorders
- Alcoholism and Thiamine Deficiency
- Advanced NMR Techniques and Applications
- Chemokine receptors and signaling
- Homelessness and Social Issues
- Psychedelics and Drug Studies
- Bipolar Disorder and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Gambling Behavior and Treatments
- Impact of Technology on Adolescents
- scientometrics and bibliometrics research
Centre for Addiction and Mental Health
2020-2025
Keio University
2015-2025
University of Toronto
2021-2025
Jikei University School of Medicine
2023
Kurihama Medical and Addiction Center
2017-2023
The University of Melbourne
2023
McGill University
2023
Douglas Mental Health University Institute
2023
Stony Brook University
2022
University of California, Davis
2022
An important proportion of infants and adolescents in Japan are using Internet-equipped devices, including smartphones, tablets, game consoles. However, the relationship between risk IA age at initial habitual Internet use remains unknown. We aimed to investigate this among adolescents.We surveyed 1,775 subjects seven public junior high schools Kanagawa prefecture, Japan, November 2017. Students were asked complete Young's Diagnostic Questionnaire (YDQ), which captured information regarding...
Abstract Background Chronic heavy alcohol consumption is known to harm health, while occasional light moderate drinking may have potential benefits. However, it unclear how modest intake affects brain structure. Aims & Objectives This study aimed examine the white matter integrity changes after a dose of acute using diffusion tensor imaging (DTI). Method Healthy individuals aged between 20 and 29, with ALDH2*1/*2 genotype, who understood gave written informed consent were included in...
Abstract Background Given the heterogeneity, particularly in terms of treatment response, and possible disease progression schizophrenia, identifying neurobiological subtypes patterns each patient may lead to novel biomarkers. Treatment-resistant schizophrenia (TRS) is a distinct subpopulation showing poor response conventional pharmacological and, as result, form illness associated with serious social economic burden. The basis TRS remains be elucidated, despite numerous strategies...
Gamma-Aminobutyric Acid (GABA) is the primary inhibitory neurotransmitter in central nervous system. GABAergic dysfunction has been implicated pathophysiology of schizophrenia. Clozapine, only approved drug for treatment-resistant schizophrenia (TRS), involves system as one its targets. However, no studies have investigated relationship between brain GABA levels, measured by proton magnetic resonance spectroscopy (1 H-MRS), and clozapine response patients with TRS.This study enrolled TRS who...
Impaired insight into illness occurs in up to 98% of patients with schizophrenia, depending on the stage illness, and leads negative clinical outcomes. Previous neuroimaging studies suggest that impaired schizophrenia may be related structural functional anomalies frontoparietal brain regions. To date, limited have investigated association between regional cerebral blood flow (CBF) schizophrenia. Therefore, we sought investigate relationship CBF, as measured by arterial spin labeling (ASL),...
Abstract Background Neuromelanin (NM) is a byproduct of monoamine metabolism, including that dopamine. NM-sensitive Magnetic Resonance Imaging (NM-MRI) sequences enable the in vivo quantification NM levels substantia nigra (SN). The NM-MRI signal considered surrogate marker for integrity SN dopamine neurons and, consequently, striatal dopaminergic functioning. Elevated synthesis associated with patients responsive to first-line antipsychotics (FLR) schizophrenia, while normal implicated...
Abstract Background Approximately 30% of patients with schizophrenia (SZ) do not respond to antipsychotic treatment. Although abnormalities the dopamine (DA) function are implicated in pathophysiology SZ, reports on striatal DA and treatment responsiveness inconsistent.The striatum is modified by released from substantia nigra (SN). Neuromelanin (NM) a product monoamine metabolism including DA. NM-sensitive MRI sequences allow vivo quantification NM levels SN. NM-MRI signal thought serve as...
<title>Abstract</title> Approximately 30% of patients with schizophrenia do not respond to antipsychotics. While has been primarily explained by the dopamine dysfunction hypothesis, treatment-resistant (TRS) may involve a different pathophysiology. Neuromelanin (NM), product metabolism in substantia nigra (SN), indirectly measures long-term synthesis capacity. Few studies have examined SN NM levels TRS. Therefore, we investigated relationship between and treatment responsiveness...
Abstract Background and Hypothesis Given the heterogeneity possible disease progression in schizophrenia, identifying neurobiological subtypes patterns each patient may lead to novel biomarkers. Here, we adopted data-driven machine-learning techniques identify of brain morphological changes schizophrenia investigate association with treatment resistance. Study Design In this cross-sectional multicenter study, included 177 patients characterized by response or resistance, 3D T1-weighted...
Acute alcohol administration affects functional connectivity, yet the underlying mechanism is unknown. Previous work suggested that a moderate dose of reduces activity gamma-aminobutyric acidergic (GABAergic) interneurons, thereby leading to state pyramidal disinhibition and hyperexcitability. The present study aims relate alcohol-induced changes in connectivity regional genetic markers GABAergic interneurons. Healthy young adults (N = 15, 5 males) underwent resting MRI scanning prior...
To investigate the acute effects of intravenous alcohol and its metabolite acetaldehyde on cognitive function in healthy individuals.Experimental pre-test/post-test design.Kurihama Medical Addiction Center, Japan.A total 298 Japanese people age 20 to 24 years.Participants underwent an infusion with a target blood concentration (BAC) 0.50 mg/mL for 180 minutes. Participants completed continuous performance test (CPT) sustained attention, paced auditory serial addition (PASAT) working memory,...
Validating the vulnerabilities and pathologies underlying treatment-resistant schizophrenia (TRS) is an important challenge in optimizing treatment. Gyrification surface area (SA), reflecting neurodevelopmental features, have been linked to genetic vulnerability schizophrenia. The aim of this study was identify gyrification SA abnormalities specific TRS.We analyzed 3T magnetic resonance imaging findings 24 healthy controls (HCs), 20 responders first-line antipsychotics (FL-Resp), 41 patients...
Abstract Background and Hypothesis Schizophrenia is associated with widespread cortical thinning abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients treatment-resistant schizophrenia (TRS) have stronger more thinning, but it remains unclear whether response schizophrenia. Study Design We organized a multicenter magnetic resonance imaging study assess large population of TRS non-TRS, who...
Abstract Background and Hypothesis The glymphatic system (GS), a brain waste clearance pathway, is disrupted in various neurodegenerative vascular diseases. As schizophrenia shares clinical characteristics with these conditions, we hypothesized GS disruptions patients spectrum disorder (SCZ-SD), reflected increased macromolecule (MM) decreased diffusion-tensor-image-analysis along the perivascular space (DTI-ALPS) index. Study Design Forty-seven healthy controls (HCs) 103 SCZ-SD were...