A5021932877- Schizophrenia research and treatment
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Electroconvulsive Therapy Studies
- Mental Health Research Topics
- Mental Health and Psychiatry
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Epilepsy research and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Attention Deficit Hyperactivity Disorder
- Diet and metabolism studies
- Mental Health Treatment and Access
- Advanced Neuroimaging Techniques and Applications
- Pharmaceutical studies and practices
- Obsessive-Compulsive Spectrum Disorders
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Psychosomatic Disorders and Their Treatments
- Microbial metabolism and enzyme function
Keio University
2016-2025
University of Toronto
2007-2025
Kurashiki Central Hospital
2018-2025
Gunma University
2024-2025
Keio University Hospital
2014-2024
Centre for Addiction and Mental Health
2014-2023
Jikei University School of Medicine
1992-2023
McGill University
2022-2023
Douglas Mental Health University Institute
2022-2023
The University of Tokyo
2011-2023
Introduction: Antipsychotic drugs exert antipsychotic effects by blocking dopamine D2 receptors in the treatment of schizophrenia. However, receptor blockade on neurocognitive function still remain to be elucidated. The objective this analysis was evaluate impacts estimated occupancy with several domains patients schizophrenia Clinical Trials Intervention Effectiveness (CATIE) trial. Methods: dataset from CATIE trial used present analysis. Data were extracted 410 subjects who treated...
Patients with late-life schizophrenia (LLS) are highly susceptible to antipsychotic adverse effects. Treatment guidelines endorse lower doses. However, the optimal dose of antipsychotics and associated dopamine D2/3 receptor (D2/3R) occupancies remain largely unexplored in patients LLS.To evaluate effects reduction on striatal D2/3R occupancies, clinical variables, blood pharmacokinetic measures LLS.An open-label, single-arm prospective study a 3- 6-month follow-up period (January 10, 2007,...