A5037977979- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Epilepsy research and treatment
- Knee injuries and reconstruction techniques
- Tendon Structure and Treatment
- Advanced Neuroimaging Techniques and Applications
- Brain Metastases and Treatment
- Neuroscience and Neuropharmacology Research
- Sports injuries and prevention
- Fetal and Pediatric Neurological Disorders
- Hedgehog Signaling Pathway Studies
- Pharmacological Effects and Toxicity Studies
- Ion channel regulation and function
- Advanced MRI Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Trigeminal Neuralgia and Treatments
- Muscle Physiology and Disorders
- Neuroscience and Neural Engineering
- Neuroscience and Music Perception
- Pharmacy and Medical Practices
- Neural and Behavioral Psychology Studies
- Cerebrospinal fluid and hydrocephalus
- Single-cell and spatial transcriptomics
Yokohama City University
2017-2025
Niigata University
2025
Children's Hospital of Michigan
2019-2024
Wayne State University
2019-2024
Detroit Medical Center
2019-2024
Yokohama City University Hospital
2024
ORCID
2021
The University of Tokyo
2017-2020
Showa University
2019
City University of Seattle
2019
OBJECT The aim of this study was to elucidate the invasiveness, effectiveness, and feasibility MRI-guided stereotactic radiofrequency thermocoagulation (SRT) for hypothalamic hamartoma (HH). METHODS authors examined clinical records 100 consecutive patients (66 male 34 female) with intractable gelastic seizures (GS) caused by HH, who underwent SRT as a sole surgical treatment between 1997 2013. median duration follow-up 3 years (range 1-17 years). Seventy cases involved pediatric patients....
Abstract Researchers have looked for rapidly- and objectively-measurable electrophysiology biomarkers that accurately localize the epileptogenic zone. Promising candidates include interictal high-frequency oscillation phase-amplitude coupling. Investigators independently created toolboxes compute rate severity of This study 135 patients determined what analytic approaches would optimally classify achieving post-operative seizure control. Four different detector computed at ≥80 Hz...
Cortico-cortical evoked potentials (CCEPs) are utilized to identify effective networks in the human brain. Following single-pulse electrical stimulation of cortical electrodes, responses recorded from distant areas. A negative deflection (N1) which occurs 10–50 ms post-stimulus is considered be a marker for direct cortico-cortical connectivity. However, with CCEPs alone it not possible observe white matter pathways that conduct signal or accurately predict N1 amplitude and latency at...
Summary Objective The strength of presurgical language mapping using electrocorticography (ECoG) is its outstanding signal fidelity and temporal resolution, but the weakness includes limited spatial sampling at an individual patient level. By averaging naming‐related high‐gamma activity nonepileptic regions across a large number patients, we provided functional cortical atlases animating neural dynamics supporting visual‐object auditory‐description naming whole brain Methods We studied 79...
We investigated the developmental changes in high-frequency oscillation (HFO) and Modulation Index (MI) - coupling measure between HFO slow-wave phase. generated normative brain atlases, using subdural EEG signals from 8251 nonepileptic electrode sites 114 patients (ages 1.0-41.5 years) who achieved seizure control following resective epilepsy surgery. observed a higher MI occipital lobe across all ages, increased notably during early childhood. The cortical areas exhibiting co-growth were...
We built normative brain atlases that animate millisecond-scale intra- and inter-hemispheric white matter-level connectivity dynamics supporting object recognition speech production. quantified electrocorticographic modulations during three naming tasks using event-related high-gamma activity from 1,114 nonepileptogenic intracranial electrodes (i.e., non-lesional areas unaffected by epileptiform discharges). Using this electrocorticography data, we visualized functional defined as...
A 45-year-old female presented with progressive right hemifacial spasm (HFS) over 6 months. Magnetic resonance imaging revealed the posterior inferior cerebellar artery (PICA) as culprit vessel for HFS and a fusiform aneurysm in vertebral (VA) just proximal to it. Following patient's request endovascular treatment of VA, stent-assisted coil embolization was performed achieve PICA deviation through VA straightening after stent placement thereby reduce symptoms. At 21 months post-procedure,...
Humans understand and respond to spoken questions through coordinated activity across distributed cortical networks. However, the causal roles of connectivity engagements alternating multiple white matter bundles remain understudied at whole-brain scale. Using intracranial high-gamma recorded from 7,792 non-epileptic electrode sites in 106 epilepsy patients who underwent direct stimulation mapping, we constructed an atlas visualizing millisecond-scale dynamics functional during a naming task...
Abstract Objective Clinical investigators have hypothesized that interictal epileptiform discharges (IEDs) generated by hypothalamic hamartoma (HH) lead to cognitive dysfunction in patients with drug‐resistant gelastic seizures. Herein we provide causal evidence supporting this hypothesis demonstrating excitatory neural bursts, when propagating from the HH mediodorsal thalamus during encoding period, impair working memory. Methods By employing channelrhodopsin‐2 photostimulation, induced...
Objective: We visualized functional and effective connectivity within specific white matter networks in response to auditory descriptive questions. Methods: investigated 40 Japanese-speaking patients with focal epilepsy estimated measures using cortical high-gamma dynamics MRI tractography. Results: Hearing a wh-interrogative at question onset enhanced inter-hemispheric connectivity, left-to-right callosal facilitatory flows between the superior-temporal gyri, contrasted by diminution...
Resective surgery for pediatric drug-resistant focal epilepsy often requires extraoperative intracranial electroencephalography recording to accurately localize the epileptogenic zone. This procedure entails multiple neurosurgeries, electrode implantation and explantation, days of invasive inpatient evaluation. There is a need methods reduce diagnostic burden introduce objective biomarkers. Our preliminary studies aimed address these issues by using sevoflurane anesthesia rapidly reversibly...
Objective Hypothalamic hamartoma (HH) is a congenital anomalous brain tumor. Although most HHs are found without any other systemic features, HH observed in syndromic disorders such as Pallister–Hall syndrome (PHS) and oral-facial-digital (OFD). Here, we explore the possible involvement of somatic mutations HH. Methods We analyzed paired blood samples from 18 individuals, including three with digital anomalies, by whole-exome sequencing. Detected were validated Sanger sequencing deep target...
OBJECTIVE The authors undertook this study to validate the feasibility and safety of stereotactic radiofrequency thermocoagulation (SRT) for surgical treatment giant hypothalamic hamartoma (HH). METHODS Of 109 patients who underwent SRT (HH) at authors' institution between 1997 2013, 16 (9 female, 7 male) had HHs (maximum diameter ≥ 30 mm). clinical records these were retrospectively reviewed. RESULTS patients' age first ranged from 1 22 years (median 5 years). maximum their was 30-80 mm...
Objective: To investigate the clinical utility of deep convolutional neural network (DCNN) tract classification as a new imaging tool in preoperative evaluation children with focal epilepsy (FE). Methods: A DCNN deeply learned spatial trajectories DWI white matter pathways linking electrical stimulation mapping (ESM) findings from 89 FE, and then automatically identified associated eloquent functions (i.e., primary motor, language, vision). Clinical was examined by 1) measuring nearest...
Abstract During a verbal conversation, our brain moves through series of complex linguistic processing stages: sound decoding, semantic comprehension, retrieval semantically coherent words, and overt production speech outputs. Each process is thought to be supported by network consisting local long-range connections bridging between major cortical areas. Both temporal extratemporal lobe regions have functional compartments responsible for distinct language domains, including the perception...
Neural electrodes for electrocorticography (ECoG) recording and electrical stimulation are used diagnosis treatment of epilepsy, which temporarily attached to the surface cerebral cortex within subdural space. However, conventional have a mechanical mismatch with curvature brain cortex. Thus, it is necessary develop thin flexible ECoG electrode overcome tissue achieve long‐term measurement. Herein, thin‐film reported thickness ≈8 µm by exploiting printed electronics. A simple fabrication...
Abstract This prospective study determined the use of intracranially recorded spectral responses during naming tasks in predicting neuropsychological performance following epilepsy surgery. We recruited 65 patients with drug-resistant focal who underwent preoperative assessment and intracranial EEG recording. The Clinical Evaluation Language Fundamentals evaluated baseline postoperative language function. During extra-operative recording, we assigned to undergo auditory picture tasks....