A5017059941- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Dementia and Cognitive Impairment Research
- Tryptophan and brain disorders
- Psychosomatic Disorders and Their Treatments
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Obsessive-Compulsive Spectrum Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Suicide and Self-Harm Studies
- Transcranial Magnetic Stimulation Studies
- Vestibular and auditory disorders
- Neural and Behavioral Psychology Studies
- Mental Health Treatment and Access
- Neurological disorders and treatments
- Mental Health Research Topics
- Electroconvulsive Therapy Studies
Centre for Addiction and Mental Health
2016-2025
University of Toronto
2016-2025
Mental Health Research Institute
2018-2025
Mental Health Research Canada
2018-2024
Keio University
2023
Jikei University School of Medicine
2023
Ontario Institute for Cancer Research
2021
University Health Network
2007-2021
Canada Research Chairs
2015-2021
Mount Sinai Hospital
2007-2009
Learning to associate auditory information of speech sounds with visual letters is a first and critical step for becoming skilled reader in alphabetic languages. Nevertheless, it remains largely unknown which brain areas subserve the learning automation such associations. Here, we employ functional magnetic resonance imaging study letter–speech sound integration children without developmental dyslexia. The results demonstrate that dyslexic show reduced neural planum temporale/Heschl sulcus...
Background Novel coronavirus disease 2019 (COVID-19) vaccine hesitancy is a barrier to achieving herd immunity, and thus, prominent public health concern. This study aimed identify the determinants of COVID-19 based on World Health Organization’s ‘3Cs’ model (i.e., confidence, complacency, convenience) in United States (U.S.) Canada. Methods Data from 7678 adults ages 18 or older were collected four most populous U.S. States, specifically New York, California, Florida, Texas,...
Introduction: Behavioural and psychological symptoms of dementia (BPSD) include agitation aggression in people with dementia. BPSD is common on inpatient psychogeriatric units may prevent individuals from living at home or residential/nursing settings. Several drugs non-pharmacological treatments have been shown to be effective reducing behavioural Algorithmic treatment address the challenge synthesizing this evidence-based knowledge. Methods: A multidisciplinary team created algorithms for...
Patients with late-life schizophrenia (LLS) are highly susceptible to antipsychotic adverse effects. Treatment guidelines endorse lower doses. However, the optimal dose of antipsychotics and associated dopamine D2/3 receptor (D2/3R) occupancies remain largely unexplored in patients LLS.To evaluate effects reduction on striatal D2/3R occupancies, clinical variables, blood pharmacokinetic measures LLS.An open-label, single-arm prospective study a 3- 6-month follow-up period (January 10, 2007,...
Food addiction is a debated topic in neuroscience. Evidence suggests diabetes related to reduced basal dopamine levels the nucleus accumbens, similar persons with drug addiction. It unknown whether insulin sensitivity endogenous ventral striatum of humans. We examined this using agonist D2/3 receptor radiotracer [11C]-(+)-PHNO and an acute depletion challenge. In separate sample healthy persons, we could alter sensitivity. Insulin was estimated for each subject from fasting plasma glucose...
Mounting evidence associates a lifetime history of major depression (LMD) with an increased risk for Alzheimer's disease (AD). Studies have shown that (MD) is strongly linked to pathophysiological markers AD, such as cortical amyl