A5024208153- Autism Spectrum Disorder Research
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Face Recognition and Perception
- Neural and Behavioral Psychology Studies
- Child and Adolescent Psychosocial and Emotional Development
- Child Development and Digital Technology
- Obsessive-Compulsive Spectrum Disorders
- Infant Health and Development
- Advanced Neuroimaging Techniques and Applications
- Action Observation and Synchronization
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Attachment and Relationship Dynamics
- Bipolar Disorder and Treatment
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Eating Disorders and Behaviors
- Neurological disorders and treatments
- Evolutionary Psychology and Human Behavior
- Memory and Neural Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Virology and Viral Diseases
- Behavioral and Psychological Studies
University of Fukui
2016-2025
Hamamatsu University School of Medicine
2014-2024
Osaka University
2014-2024
Kanazawa University
2014-2024
Chiba University
2014-2024
University of Fukui Hospital
2015-2024
Shionogi (Japan)
2021
Takeda (Japan)
2021
Kantar Health (United States)
2021
National Institute of Mental Health
2014
Compelling evidence in Caucasian populations suggests a role for copy-number variations (CNVs) autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 ASD cases, 2,458 SCZ 2,095 controls Japanese population confirmed an increased burden of rare exonic CNVs both disorders. Clinically significant (or pathogenic) CNVs, including those at 29 loci common to disorders, were found about 8% which was significantly higher than controls. Phenotypic analysis revealed association...
Abstract Some involvement of the human amygdala in processing facial expressions has been investigated neuroimaging studies, although neural mechanisms underlying motivated or emotional behavior response to stimuli are not yet fully understood. We investigated, using functional magnetic resonance imaging (fMRI) and healthy volunteers, how interacts with other cortical regions while subjects judging sex faces negative, positive, neutral emotion. The data were analyzed by a subtractive method,...
Eye contact provides a communicative link between humans, prompting joint attention. As spontaneous brain activity may have an important role in coordination of neuronal processing within the brain, their inter-subject synchronization occur during eye contact. To test this, we conducted simultaneous functional MRI pairs adults. was maintained at baseline while subjects engaged real-time gaze exchange attention task. Averted activated bilateral occipital pole extending to right posterior...
Abstract Age‐related differences involved in the neural substrates of emotional face perception were investigated young and old healthy volunteers. The subjects scanned using functional magnetic resonance imaging while they judging gender faces with negative, positive, or neutral valence. results showed that both predominant activation reduced activity contributed to a significant age difference left amygdala during negative faces. Activity right parahippocampal gyrus positive diminished...
Autism spectrum traits are postulated to lie on a continuum that extends between individuals with autism and typical development (TD). Social cognition properties deeply associated have been linked functional connectivity regions within the brain's default mode network (DMN). Previous studies shown resting-state connectivities (rs-FCs) of DMN low show negative correlation level in disorder (ASD). However, it is unclear whether individual differences strength rs-FCs participants including...
Abstract Recent studies have suggested that long-term oxytocin administration can alleviate the symptoms of autism spectrum disorder (ASD); however, factors influencing its efficacy are still unclear. We conducted a single-center phase 2, pilot, randomized, double-blind, placebo-controlled, parallel-group, clinical trial in young adults with high-functioning ASD, to determine whether dosage and genetic background receptor affects efficacy. This consisted double-blind (12 weeks), open-label...
Meditation is a specific consciousness state in which deep relaxation and increased internalized attention coexist. There have been various neurophysiological studies on meditation. However, the personal predispositions/traits that characterize properties of meditation not adequately studied. We analyzed changes parameters [EEG coherence autonomic nervous activity using heart rate variability (HRV) as an index] during Zen meditation, evaluated results association with trait anxiety (assessed...
Individuals with autism spectrum disorders (ASD) are known to have difficulty eye contact. This might make it difficult for partners communicate them face-to-face. To elucidate the neural substrates of live inter-subject interactions ASD patients and typically-developed (normal) subjects, we conducted hyper-scanning functional MRI 21 subjects autistic disorder paired normal 19 pairs as a control. Baseline contact was maintained while performed real-time joint-attention task. The task-related...
Approximately half of autism spectrum disorder (ASD) individual suffer from comorbid intellectual disabilities (ID). Oxytocin (OXT) receptors are highly expressed in temporal lobe structures and likely to play a modulatory role excitatory/inhibitory balance, at least based on animal model findings. Thus, it is feasible that the representative group Kanner type ASD subjects OXT could have beneficial effect social communication interaction. The aim this pilot study was investigate feasibility...
Gaze abnormality is a diagnostic criterion for autism spectrum disorder (ASD). However, few easy-to-use clinical tools exist to evaluate the unique eye-gaze patterns of ASD. Recently, we developed Gazefinder, an all-in-one eye-tracking system early detection ASD in toddlers. Because abnormal gaze have been documented various age groups, predicted that Gazefinder might also detect adolescents and adults. In this study, tested whether could identify adults with We measured percentage eye...
Oxytocin (OT) signalling represents one of the most critical systems involved in human social behaviour. Although several studies have examined relationship between functioning and peripheral OT levels, association development attention has not been well studied. Therefore, we investigated developmental gaze fixation for cues levels during young childhood. We visual using an eye tracking system infants children (5-90 months age) measured concentration saliva samples. observed a negative age...
Abstract Although intranasal oxytocin is expected to be a novel therapy for the core symptoms of autism spectrum disorder, which has currently no approved medication, efficacy repeated administrations was inconsistent, suggesting that optimal dose single administration not administration. The current double-blind, placebo-controlled, multicentre, crossover trial (ClinicalTrials.gov Identifier: NCT03466671) aimed test effect TTA-121, new formulation spray with an enhanced bioavailability (3.6...
BackgroundWe aimed to determine the similarities and differences in roles of genic regulatory copy number variations (CNVs) bipolar disorder (BD), schizophrenia (SCZ), autism spectrum (ASD).MethodsBased on high-resolution CNV data from 8708 Japanese samples, we performed our knowledge largest cross-disorder analysis CNVs BD, SCZ, ASD.ResultsIn CNVs, found an increased burden smaller (<100 kb) exonic deletions which contrasted with highest larger (>500 SCZ/ASD. Pathogenic linked...
Recent findings suggest that stigma and camouflaging contribute to mental health difficulties for autistic individuals, however, this evidence is largely based on UK samples. While studies have shown cross-cultural differences in levels of autism-related stigma, it unclear whether vary across cultures. Hence, the current study had two aims: (1) determine significant relationships between autism acceptance, camouflaging, replicate a sample adults, (2) compare these variables To fulfil aims,...
Patients with autism spectrum disorders (ASDs) exhibit core autistic symptoms including social impairments from early childhood and mostly show secondary disabilities such as irritability aggressive behavior based on symptoms. However, there are still no radical treatments of in these patients. Oxytocin has been reported to play important roles multiple behaviors dependent recognition, expected one the effective patients ASDs. We present a case 16-year-old girl disorder who treated by...
Child maltreatment is a major risk factor for psychopathology, including reactive attachment disorder (RAD).To examine whether neural activity during reward processing was altered in children and adolescents with RAD.Sixteen RAD 20 typically developing (TD) individuals performed tasks high low monetary rewards while undergoing functional magnetic resonance imaging.Significantly reduced the caudate nucleus accumbens observed condition group compared TD (P=0.015, family-wise error-corrected...
This study was designed to ascertain the relationship between visual attention for social information and oxytocin (OT) levels in Japanese preschool children with autism spectrum disorder (ASD). We hypothesized that poor low OT are crucially important risk factors associated ASD. measured pattern of gaze fixation using an eye-tracking system, salivary by Enzyme-Linked Immunosorbent Assay (ELISA). There a positive association duration indicated object area finger-pointing movie typically...
BACKGROUND AND OBJECTIVES Geriatric depression is often thought to differ from that at other times of adulthood. Recently, several studies have shown the incidence white matter hyperintense lesions identified by brain MRI higher in patients with geriatric than healthy elderly subjects, but a consensus has not yet been reached on relationship between severity and either cognitive impairment or depressive symptoms.Forty-seven aged 50 75 years major were divided into two groups based age onset...