A5082170531- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Spatial and Panel Data Analysis
- Neuroscience and Music Perception
- Heart Rate Variability and Autonomic Control
- Optical Imaging and Spectroscopy Techniques
- Neuroendocrine regulation and behavior
- Neural and Behavioral Psychology Studies
- Obsessive-Compulsive Spectrum Disorders
- demographic modeling and climate adaptation
- EEG and Brain-Computer Interfaces
- Infant Health and Development
- Child Development and Digital Technology
- Child and Adolescent Psychosocial and Emotional Development
- Neural dynamics and brain function
- Evolutionary Psychology and Human Behavior
- Schizophrenia research and treatment
- Bayesian Methods and Mixture Models
- Insurance, Mortality, Demography, Risk Management
- Income, Poverty, and Inequality
- Economic and Environmental Valuation
- Genetics and Neurodevelopmental Disorders
Chiba University
2015-2024
The University of Tokyo
2012-2023
University of Tokyo Hospital
2018
Nagoya University
2018
Moscow Research and Clinical Center for Neuropsychiatry
2006-2016
Tokyo Medical University
2011
Showa University
2010
Japan Science and Technology Agency
2010
Kumamoto University
2008
University of Tsukuba
2001-2004
Although autism spectrum disorder (ASD) is a serious lifelong condition, its underlying neural mechanism remains unclear. Recently, neuroimaging-based classifiers for ASD and typically developed (TD) individuals were to identify the abnormality of functional connections (FCs). Due over-fitting interferential effects varying measurement conditions demographic distributions, no have been strictly validated independent cohorts. Here we overcome these difficulties by developing novel...
Autism spectrum disorder is a prevalent neurodevelopmental with no established pharmacological treatment for its core symptoms. Although previous literature has shown that single-dose administration of oxytocin temporally mitigates autistic social behaviours in experimental settings, it remains dispute whether such potentially beneficial responses laboratories can result clinically positive effects daily life situations, which are measurable only long-term observations individuals the...
Recent studies have suggested oxytocin's therapeutic effects on deficits in social communication and interaction autism spectrum disorder through improvement of emotion recognition with direct emotional cues, such as facial expression voice prosody. Although difficulty understanding others' emotions beliefs under conditions without cues also plays an important role disorder, no study has examined the potential effect oxytocin this difficulty. Here, we sequentially conducted both a...
Sociocommunicational deficits make it difficult for individuals with autism spectrum disorders (ASD) to understand communication content conflicting verbal and nonverbal information. Despite growing prospects oxytocin as a therapeutic agent ASD, no direct neurobiological evidence exists oxytocin's beneficial effects on this core symptom of ASD. This is slowing clinical application the neuropeptide.To directly examine whether has sociocommunicational ASD using both behavioral neural...
Objective Recent epidemiologic studies worldwide have documented a rise in prevalence rates for autism spectrum disorders ( ASD ). Broadening of diagnostic criteria may be major contributor to the prevalence, particularly if superimposed on an underlying continuous distribution autistic traits. This study sought determine nature population traits using quantitative trait measure large national sample children. Method The J apanese version Social Responsiveness Scale SRS ) was completed by...
The neuropeptide oxytocin may be an effective therapeutic strategy for the currently untreatable social and communication deficits associated with autism. Our recent paper reported that mitigated autistic behavioral through restoration of activity in ventromedial prefrontal cortex (vmPFC), as demonstrated functional magnetic resonance imaging (fMRI) during a socio-communication task. However, it is unknown whether exhibited effects at neuronal level, which was outside specific task examined....
Clinical diagnosis and severity of autism spectrum disorders (ASD) are determined by trained clinicians based on clinical evaluations observed behaviors. As such, this approach is inevitably dependent the expertise subjective assessment those administering evaluations. There a need to identify objective biological markers associated with or disorder. To novel candidate metabolites as potential biomarkers for ASD, current study applied capillary electrophoresis time-of-flight mass...
Information processing deficits in major depressive disorder have been infrequently examined electrophysiologically. Its preattentive and sensory information was using mismatch field (MMNm) P1m components, respectively, by magnetoencephalography. Fourteen patients 19 healthy volunteers participated the study. MMNm elicited response to duration frequency changes of pure-tone stimuli a vowel across-category change. The magnetic global power (mGFP) significantly smaller than volunteers,...
Individuals with autism spectrum disorders (ASD) tend to make inadequate social judgments, particularly when the nonverbal and verbal emotional expressions of other people are incongruent. Although previous behavioral studies have suggested that ASD individuals difficulty in using cues presented incongruent verbal-nonverbal information, neural mechanisms underlying this symptom remain unclear. In present functional magnetic resonance imaging study, we compared brain activity 15 non-medicated...
Deficits in auditory sensory memory at the electrophysiological level as indexed by mismatch negativity and those verbal neuropsychological have been independently demonstrated previous studies of schizophrenia. We predicted a specific association between these indices Mismatch negativities elicited change tone duration phoneme were recorded 23 schizophrenia patients, who also evaluated for executive function. Lower amplitude under phoneme-duration condition was significantly associated with...
The differential diagnosis of autism spectrum disorders (ASDs) and attention deficit hyperactivity disorder (ADHD) based solely on symptomatic behavioral assessments can be difficult, even for experts. Thus, the development a neuroimaging marker that differentiates ASDs from ADHD would an important contribution to this field. We assessed differences in prefrontal activation between adults with using entirely non-invasive portable tool, near-infrared spectroscopy. This study included 21...
To develop novel interventions for autism spectrum disorder (ASD) core symptoms, valid, reliable, and sensitive longitudinal outcome measures are required detecting symptom change over time. Here, we tested whether a computerized analysis of quantitative facial expression could act as marker ASD social symptoms. Facial intensity values during semi-structured socially interactive situation extracted from the Autism Diagnostic Observation Schedule (ADOS) were quantified by dedicated software...