A5017148079- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Neuroendocrine regulation and behavior
- Infant Health and Development
- Autism Spectrum Disorder Research
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Neural and Behavioral Psychology Studies
- Evolutionary Psychology and Human Behavior
- Obsessive-Compulsive Spectrum Disorders
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Child Development and Digital Technology
- Attention Deficit Hyperactivity Disorder
- Heart Rate Variability and Autonomic Control
- Epigenetics and DNA Methylation
- Optical Imaging and Spectroscopy Techniques
- Pain Management and Placebo Effect
- Treatment of Major Depression
- Neuroscience and Music Perception
- Advanced Neuroimaging Techniques and Applications
- Hemispheric Asymmetry in Neuroscience
- Digital Communication and Language
- Antioxidant Activity and Oxidative Stress
The University of Tokyo
2011-2021
Moscow Research and Clinical Center for Neuropsychiatry
2019
Subcortical structures, which include the basal ganglia and parts of limbic system, have key roles in learning, motor control emotion, but also contribute to higher-order executive functions. Prior studies reported volumetric alterations subcortical regions schizophrenia. Reported results sometimes been heterogeneous, few large-scale investigations conducted. Moreover, assessed asymmetries volumes Here, as a work completely independent study performed by ENIGMA consortium, we conducted...
Autism spectrum disorder is a prevalent neurodevelopmental with no established pharmacological treatment for its core symptoms. Although previous literature has shown that single-dose administration of oxytocin temporally mitigates autistic social behaviours in experimental settings, it remains dispute whether such potentially beneficial responses laboratories can result clinically positive effects daily life situations, which are measurable only long-term observations individuals the...
Recent studies have suggested oxytocin's therapeutic effects on deficits in social communication and interaction autism spectrum disorder through improvement of emotion recognition with direct emotional cues, such as facial expression voice prosody. Although difficulty understanding others' emotions beliefs under conditions without cues also plays an important role disorder, no study has examined the potential effect oxytocin this difficulty. Here, we sequentially conducted both a...
Sociocommunicational deficits make it difficult for individuals with autism spectrum disorders (ASD) to understand communication content conflicting verbal and nonverbal information. Despite growing prospects oxytocin as a therapeutic agent ASD, no direct neurobiological evidence exists oxytocin's beneficial effects on this core symptom of ASD. This is slowing clinical application the neuropeptide.To directly examine whether has sociocommunicational ASD using both behavioral neural...
Abstract Neuropsychiatric disorders are diagnosed based on behavioral criteria, which makes the diagnosis challenging. Objective biomarkers such as neuroimaging needed, and when coupled with machine learning, can assist diagnostic decision increase its reliability. Sixty-four schizophrenia, 36 autism spectrum disorder (ASD), 106 typically developing individuals were analyzed. FreeSurfer was used to obtain data from participant’s brain scans. Six classifiers utilized classify subjects....
Changes in brain pathology as schizophrenia progresses have been repeatedly suggested by previous studies. Meta-analyses of proton magnetic resonance spectroscopy (1H MRS) studies at each clinical stage indicate that the abnormalities N-acetylaspartate (NAA) and glutamatergic metabolites change progressively. However, to our knowledge, no single study has addressed possible differences 1H MRS subjects 3 different stages disease, including those ultrahigh risk for psychosis (UHR), with...
The neuropeptide oxytocin may be an effective therapeutic strategy for the currently untreatable social and communication deficits associated with autism. Our recent paper reported that mitigated autistic behavioral through restoration of activity in ventromedial prefrontal cortex (vmPFC), as demonstrated functional magnetic resonance imaging (fMRI) during a socio-communication task. However, it is unknown whether exhibited effects at neuronal level, which was outside specific task examined....
Few biomarkers have been known that can easily measure clinical conditions in mental illnesses such as schizophrenia. Capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) is a new method ionized and low-molecular-weight metabolites. To explore global metabolomic alterations characterize the onset of schizophrenia identify biomarkers, we profiled relative absolute concentrations plasma metabolites from 30 patients with first-episode (FESZ, four drug-naïve samples), 38 healthy...
Clinical diagnosis and severity of autism spectrum disorders (ASD) are determined by trained clinicians based on clinical evaluations observed behaviors. As such, this approach is inevitably dependent the expertise subjective assessment those administering evaluations. There a need to identify objective biological markers associated with or disorder. To novel candidate metabolites as potential biomarkers for ASD, current study applied capillary electrophoresis time-of-flight mass...
Individuals with autism spectrum disorders (ASD) tend to make inadequate social judgments, particularly when the nonverbal and verbal emotional expressions of other people are incongruent. Although previous behavioral studies have suggested that ASD individuals difficulty in using cues presented incongruent verbal-nonverbal information, neural mechanisms underlying this symptom remain unclear. In present functional magnetic resonance imaging study, we compared brain activity 15 non-medicated...
Oxytocin appears beneficial for autism spectrum disorder (ASD), and more than 20 single-nucleotide polymorphisms (SNPs) in oxytocin receptor (OXTR) are relevant to ASD. However, neither biological functions of OXTR SNPs ASD nor critical that determine oxytocin's effects on remains known. Here, using a machine-learning algorithm was designed evaluate collective multiple automatically identify most informative SNPs, we examined relationships between 27 representative six types...
Atypical trajectory of brain growth in autism spectrum disorders (ASDs) has been recognized as a potential etiology an atypical course behavioral development. Numerous neuroimaging studies have focused on childhood to investigate age-related change structure and function, because it is period neuron synapse maturation. Recent studies, however, shown that the structural autistic expands beyond constitutes neural underpinnings for lifelong difficulty adaptation. Thus, we examined effects aging...
Social judgments often require resolution of incongruity in communication contents. Although previous studies revealed that such conflict recruits brain regions including the medial prefrontal cortex (mPFC) and posterior inferior frontal gyrus (pIFG), functional relationships networks among these remain unclear. In this magnetic resonance imaging study, we investigated dissociation by measuring human activity during resolving between verbal non-verbal emotional First, found resolutions...
Associations between altered DNA methylation of the serotonin transporter (5-HTT)-encoding gene SLC6A4 and early life adversity, mood anxiety disorders, amygdala reactivity have been reported. However, few studies examined epigenetic alterations in schizophrenia (SZ). We CpG sites SLC6A4, whose levels reported to be bipolar disorder, using 3 independent cohorts patients with SZ age-matched controls. found significant hypermethylation a site male all cohorts. showed that chronic...
Although advanced paternal and maternal age at birth (PA/MA) increases the risk of autism spectrum disorder (ASD), underlying neurobiological mechanisms are not fully understood. To explore neuroanatomical correlates PA/MA, current study conducted brain morphometric analyses in 39 high-functioning adult males with ASD age-, intellectual level-, parental socioeconomic background-matched, typically developed (TD) males. Whole-brain analysis revealed that regional gray matter volume (GMV)...
Although advanced parental age holds an increased risk for autism spectrum disorder (ASD), its role as a potential factor atypical white matter development underlying the pathophysiology of ASD has not yet been investigated. The current study was aimed to detect disparities in ASD, and further investigate relationship paternal maternal at birth with such disparities.
Comprehensive approaches for patients with psychotic symptoms play essential roles in the symptomatic and functional outcomes of patients, especially during disease onset. In Japan, shortage mental health services, particularly outpatients, community-based supports has been a major problem. The purpose this trial is to investigate effectiveness affordability 18-month comprehensive early intervention services first-episode psychosis compared typical treatment. This interventional, parallel,...