A5056225189- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Advanced Glycation End Products research
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Crustacean biology and ecology
- Fish Biology and Ecology Studies
- Genomic variations and chromosomal abnormalities
- MicroRNA in disease regulation
- Folate and B Vitamins Research
- Identification and Quantification in Food
- Diabetes Management and Research
- Stress Responses and Cortisol
- Isotope Analysis in Ecology
- Rice Cultivation and Yield Improvement
- Hedgehog Signaling Pathway Studies
- Marine and fisheries research
- Fish biology, ecology, and behavior
- RNA Research and Splicing
- Decision-Making and Behavioral Economics
- Restless Legs Syndrome Research
- Soil Geostatistics and Mapping
Juntendo University
2021-2025
Weatherford College
2024
Japan Fisheries Research and Education Agency
2019-2024
Tokyo Metropolitan Matsuzawa Hospital
2020-2022
Tokyo Metropolitan Institute of Medical Science
2020-2022
Northwestern University
2017-2022
Meguro Parasitological Museum
2021
The University of Tokyo
2013-2020
Kyoto University
2007-2018
Accumulating evidence suggests that epigenetic alterations in brain-derived neurotrophic factor (BDNF) promoters are associated with the pathophysiology of psychiatric disorders. Epigenetic changes BDNF were reported not only brain tissues but also other tissues, including peripheral blood cells (PBC) and saliva. We examined DNA methylation levels I IV using genomic derived from PBC healthy controls (n = 100), patients schizophrenia all Japanese population, by pyrosequencing. The CpG sites...
Prediction of treatment response by genetic biomarkers has potential for clinical use and contributes to the understanding pathophysiology drug mechanism action. The purpose this study is detect possibly associated with lurasidone, during first four weeks treatment. One-hundred seventy-one acutely psychotic patients from two placebo-controlled trials lurasidone were included. Genetic associations changes in Positive Negative Syndrome Scale total score at one, two, examined. Genotyping was...
We have reported that a subpopulation of patients with schizophrenia lower levels vitamin B6 (VB6) in peripheral blood than do healthy controls. In previous study, we found VB6 level was inversely proportional to the patient's positive and negative symptom scale (PANSS) score for measuring severity, suggesting loss might contribute development symptoms. present clarify relationship between deficiency schizophrenia, generated VB6-deficient (VB6(-)) mice through feeding VB6-lacking diet as...
Schizophrenia (SZ) and bipolar disorder (BD) have been known to share genetic environmental risk factors, complex gene-environmental interactions may contribute their pathophysiology. In contrast high overlap between SZ BD, as revealed by genome-wide association studies, the extent of epigenetic remains largely unknown. present study, we explored whether BD factors in same manner they components.We performed DNA methylation analyses CpG sites top five candidate regions (FAM63B, ARHGAP26,...
Recent studies have shown that microRNAs (miRNAs) play a role as regulators of neurodevelopment by modulating gene expression. Altered miRNA expression has been reported in various psychiatric disorders, including schizophrenia. However, the changes profile occur during initial stage schizophrenia not fully investigated. To explore global alterations profiles may be associated with onset schizophrenia, we first profiled plasma from 17 patients first-episode and healthy controls using...
Abstract Psychotic-like experiences (PLEs) occur occasionally in adolescence and mostly disappear with increasing age. Their presence, if persistent, is considered a robust risk factor for subsequent psychiatric disorders. To date, only few biological markers have been investigated persistent PLE prediction. This study identified urinary exosomal microRNAs that can serve as predictive biomarkers PLEs. was part of population-based biomarker subsample the Tokyo Teen Cohort Study. A total 345...
Methylglyoxal (MG) is a reactive and cytotoxic α-dicarbonyl byproduct of glycolysis. Our bodies have several bio-defense systems to detoxify MG, including an enzymatic system by glyoxalase (GLO) 1 GLO2. We identified subtype schizophrenia patients with novel mutations in the GLO1 gene that results reductions activity. Moreover, we found vitamin B6 (VB6) levels peripheral blood dysfunction are significantly lower than healthy controls. However, effects VB6 deficiency on pathophysiology...
Monozygotic twins are assumed to have identical genomes. Based on this assumption, phenotypic discordance in monozygotic has been previously attributed environmental factors. However, recent genomic studies identified characteristic somatic mutations discordant for Darier disease, Van der Woude syndrome, and Dravet syndrome. Here, we explored four pairs of schizophrenia or delusional disorder. We analyzed whole exome sequence data obtained from blood samples seven one twin pair All these...
Abstract We examined whether common variants from the extended major histocompatibility complex (xMHC) region contribute to response antipsychotic drugs (APDs) in patients with schizophrenia persistent psychosis. Subjects participated a prospective longitudinal study of effect APDs on psychopathology were temporally split into discovery ( n = 88) and replication 42) cohorts. The primary endpoint was change Brief Psychiatric Rating Scale at 6-week or 6-month after treatment. rs204991 β 3.917,...
An annotated checklist of benthic fishes on the western part Kitami-Yamato Bank off northeastern Hokkaido, Japan in southern Sea Okhotsk, is presented based voucher specimens with accompanying color photographs.All material was collected late April, 2013 and 2014 by bottom trawl net, a total 450 being classified into 92 species representing 21 families.These include Bathyraja trachouros, first record from Careproctus segaliensis, only second confirmed species.
Associations between altered DNA methylation of the serotonin transporter (5-HTT)-encoding gene SLC6A4 and early life adversity, mood anxiety disorders, amygdala reactivity have been reported. However, few studies examined epigenetic alterations in schizophrenia (SZ). We CpG sites SLC6A4, whose levels reported to be bipolar disorder, using 3 independent cohorts patients with SZ age-matched controls. found significant hypermethylation a site male all cohorts. showed that chronic...
Abstract Introduction Impulsivity in intertemporal choice has been operationalized as “delay discounting”, referring to the preference for a sooner, smaller reward. FK506 binding protein 5 ( FKBP5 ) is co‐chaperone of glucocorticoid receptor GR ). overexpression causes resistance, resulting increased plasma cortisol levels. High levels are associated with low impulsivity choice. The aim this study was explore effect single nucleotide polymorphisms SNPs on delay discounting. Methods...
Introduction: Impulsivity in intertemporal choice has been operationalized as “delay discounting,” referring to the preference for a sooner, smaller reward neuroeconomics. It is reportedly associated with dopaminergic systems. Dopamine receptor D2 (DRD2) subtype of dopamine G-protein coupled family. The aim this study was explore effect single nucleotide polymorphisms (SNPs) DRD2 gene on delay discounting. Methods: participants consisted 91 healthy Japanese people (66 males and 25 females...
Mental health problems, such as depression, are increasingly common among workers. Job-related stresses, including psychological demands and a lack of discretion in controlling one's own work environment, important causal factors. However, the mechanisms through which job-related stress may affect brain function remain unknown. We sought to identify relationship between frontotemporal cortex activation using near-infrared spectroscopy. Seventy-nine (45 females, 34 males) Japanese employees,...
Plasma N-terminal pro-atrial natriuretic peptide (NT-proANP) concentration increases with progression of myxomatous mitral valve disease (MMVD) in dogs. This multicentre, prospective study compared plasma NT-proANP, pro-brain (NT-proBNP), ANP, and cardiac troponin I (cTnI) concentrations dogs MMVD for their characteristics discriminatory ability to detect dilatation congestive heart failure (CHF). Thirty-six healthy 69 were included. Clinical variables obtained via physical examination,...
Advanced glycation end products play a key role in the pathophysiology of schizophrenia. Cognitive impairment is one central features schizophrenia; however, association between advanced and cognitive remains unknown. This study investigated whether affect domain patients with A total 58 chronic schizophrenia were included this cross-sectional study. Plasma measured using high-performance liquid chromatography (HPLC). Neuropsychological functions assessed Wechsler Adult Intelligence Scale,...
Abstract Case control studies have suggested that advanced glycation end products play a key role in the pathophysiology of chronic schizophrenia. However, longitudinal association between and psychotic symptoms among drug-naïve adolescents remains unclear. This study examined whether could predict trajectory drug-naive using data from prospective population-based biomarker subsample Tokyo Teen Cohort. A total 277 community-dwelling aged 13 years without antipsychotic medication were...
Abstract Previously, we identified a subpopulation of schizophrenia (SCZ) showing increased levels plasma pentosidine, marker glycation and oxidative stress. However, its causative genetic factors remain largely unknown. Recently, it has been suggested that dysregulated posttranslational modification by copy number variable microRNAs (CNV-miRNAs) may contribute to the etiology SCZ. Here, an integrative genome-wide CNV-miRNA analysis was performed investigate SCZ with accumulated pentosidine...
イネ‐コムギ‐ダイズを2年3作で作付ける田畑輪換田において, 2002年から2004年播コムギを対象に, コムギ収量の圃場内変動をもたらす要因を解析し, その要因の圃場内変動に応じて肥料や種子などの農業資材の投入量を変化させ圃場内の収量変動を是正する可変量管理の可能性を検討した. 収量変動に対して穂数の寄与が1穂整粒数および千粒重に比較して高く, 収量を是正するには穂数を可変量管理の対象とするのが効率的と考えられた. そして播種量が苗立ち数を左右し, 苗立ち数に影響される小穂分化期窒素保有量そして茎数が穂数を左右すると共に, 播種時土壌含水比は出芽深度を左右することで穂数に強く影響していたと考えられた. これらの事から, 播種時土壌含水比の圃場内変動に応じて播種量を制御する可変量管理によって, 場所ごとの穂数を是正することで圃場の平均収量を是正し得るものと考えられた. この可変量管理は, 収量の圃場内変動のうち是正できる可能性を有する変動の42.7%を是正できると判断された.
The mechanism underlying the vulnerability to developing schizophrenia (SCZ) during adolescence remains elusive. Hypofunction of N-methyl-d-aspartate receptors (NMDARs) has been implicated in pathophysiology SCZ. During development, composition synaptic NMDARs dramatically changes from NR2B-containing NR2A-containing through phosphorylation NR2B S1480 or Y1472 by CDK5, CSNK2A1, and EphB2, which plays a pivotal role maturation neural circuits. We hypothesized that dysregulation developmental...