A5010794898- Functional Brain Connectivity Studies
- Optical Imaging and Spectroscopy Techniques
- Schizophrenia research and treatment
- Heart Rate Variability and Autonomic Control
- Mental Health Research Topics
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Bipolar Disorder and Treatment
- Neural and Behavioral Psychology Studies
- Blood Pressure and Hypertension Studies
- Neuroscience and Music Perception
- Mental Health and Psychiatry
- Treatment of Major Depression
- Psychosomatic Disorders and Their Treatments
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Family Caregiving in Mental Illness
- Gambling Behavior and Treatments
- RNA Research and Splicing
- Neurological Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Neurobiology of Language and Bilingualism
- Family Support in Illness
- Alcoholism and Thiamine Deficiency
- Fibromyalgia and Chronic Fatigue Syndrome Research
The University of Tokyo
2015-2024
Office of Diversity and Inclusion
2024
Few biomarkers have been known that can easily measure clinical conditions in mental illnesses such as schizophrenia. Capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) is a new method ionized and low-molecular-weight metabolites. To explore global metabolomic alterations characterize the onset of schizophrenia identify biomarkers, we profiled relative absolute concentrations plasma metabolites from 30 patients with first-episode (FESZ, four drug-naïve samples), 38 healthy...
Abstract Previous studies have shown glutamatergic dysfunction and γ-aminobutyric acid (GABA)-ergic in schizophrenia. Animal suggest that N-methyl- d -aspartate receptor (NMDAR) GABA-ergic interact with each other lead to alterations excitatory/inhibitory balance. The NMDAR GABAergic-interneuron functions may be indexed by mismatch negativity (MMN) auditory steady-state gamma-band response (ASSR), respectively. However, no previous tested the hypothesis of an abnormal association between MMN...
Abstract Discrepancies in self-rated and observer-rated depression severity may underlie the basis for biological heterogeneity depressive disorders be an important predictor of outcomes indicators to optimize intervention strategies. However, neural mechanisms underlying this discrepancy have been understudied. This study aimed examine brain networks that represent between using resting-state functional MRI. To severity, self- observer-ratings (SOD) was defined, higher lower SOD groups were...
Abstract Several animal models of schizophrenia and patients with chronic have shown increased spontaneous power gamma oscillations. However, the most robust alterations oscillations in are reduced auditory–oscillatory responses. We hypothesized that early-stage would This study included 77 participants, including 27 ultra-high-risk (UHR) individuals, 19 recent-onset (ROS), 31 healthy controls (HCs). The auditory steady-state response (ASSR) measured as induced during ASSR period were...
Abstract Methamphetamine abuse and dependence, frequently accompanied by schizophrenia‐like psychotic symptoms [methamphetamine‐associated psychosis ( MAP )], is a serious public health problem worldwide. Few studies, however, have characterized brain dysfunction associated with , nor investigated similarities differences in between schizophrenia. We compared prefrontal cortical activity stop‐signal inhibitory task 21 patients 14 schizophrenia age‐ gender‐matched healthy controls using...
Aim There is an increasing need for identifying neurocognitive predictors of global functional outcome in early psychosis toward optimizing intervention strategy. Methods We conducted a longitudinal observational study to investigate association between assessments at baseline and average 1‐year follow up. Participants included ultra‐high‐risk ( UHR ) individuals who had not converted during the follow‐up period UHR‐NP those with first‐episode FEP ). evaluated neurocognition using Brief...
Recent studies have shown that microRNAs (miRNAs) play a role as regulators of neurodevelopment by modulating gene expression. Altered miRNA expression has been reported in various psychiatric disorders, including schizophrenia. However, the changes profile occur during initial stage schizophrenia not fully investigated. To explore global alterations profiles may be associated with onset schizophrenia, we first profiled plasma from 17 patients first-episode and healthy controls using...
In the early intervention in psychosis, ultra-high risk (UHR) criteria have been used to identify individuals who are prone develop psychosis. Although transition rate psychosis at UHR is 10% 30% within several years, some present with poor prognoses even without occurring. Therefore, it important biomarkers for predicting prognosis of UHR, regardless transition. We investigated whether mismatch negativity (MMN) response both duration deviant stimuli (dMMN) and frequency (fMMN) could predict...
Research efforts aiming at neuroimaging-aided differential diagnosis for psychiatric disorders have been progressing rapidly. A previous multisite study has developed a supplementary diagnostic system using functional near-infrared spectroscopy (fNIRS) that can be easily applied to clinical settings. However, few neuroimaging biomarkers the psychosis spectrum with various stages.We employed fNIRS as examination device 143 participants, comprising 47 ultra-high risk (UHR) individuals, 30...
Children with special health care needs (CSHCN) are those who require more for their physical, developmental, or emotional differences than typically developing peers. Among a wide range of burdens that caregivers CSHCN experience, the mental burden is still not well investigated. This study aimed at examining relationship between caring and mothers' anxiety/depression.This used data from Tokyo Early Adolescence Survey, population-based cross-sectional survey. Using screening questionnaires,...
Abstract Background The prefrontal deficits in psychiatric disorders have been investigated using functional neuroimaging tools; however, no studies tested the related characteristics across considering various demographic and clinical confounders. Methods We analyzed 1558 brain measurements a near-infrared spectroscopy during verbal fluency task from 1200 participants with three disease spectra [196 schizophrenia, 189 bipolar disorder (BPD), 394 major depressive (MDD)] 369 healthy controls...
Background Schizophrenia is a complex mental disorder characterized by significant cognitive and neurobiological alterations. Impairments in function eye movement have been known to be promising biomarkers for schizophrenia. However, assessment methods require specialized expertise. To date, data on simplified measurement tools assessing both patients with schizophrenia are lacking. Objective This study aims assess the efficacy of novel tablet-based platform combining measures classifying...
Mental health problems, such as depression, are increasingly common among workers. Job-related stresses, including psychological demands and a lack of discretion in controlling one's own work environment, important causal factors. However, the mechanisms through which job-related stress may affect brain function remain unknown. We sought to identify relationship between frontotemporal cortex activation using near-infrared spectroscopy. Seventy-nine (45 females, 34 males) Japanese employees,...
Near-infrared spectroscopy (NIRS) is a functional neuroimaging modality that has advantages in clinical usage. Previous magnetic resonance imaging (fMRI) studies have found the resting-state connectivity (RSFC) of default mode network (DMN) increased, while RSFC cognitive control (CCN) reduced patients with major depressive disorder (MDD) compared healthy controls. This study tested whether NIRS-based measurements can detect abnormalities been associated MDD previous fMRI studies. We...