A5035002995- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Bone health and treatments
- Dialysis and Renal Disease Management
- Head and Neck Cancer Studies
- Bone and Joint Diseases
- Metabolism, Diabetes, and Cancer
- Neural dynamics and brain function
- Neuroscience and Music Perception
- Digital Imaging for Blood Diseases
- Tumors and Oncological Cases
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- AI in cancer detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bone Tumor Diagnosis and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related gene regulation
- Hearing, Cochlea, Tinnitus, Genetics
- Testicular diseases and treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Colorectal and Anal Carcinomas
- Neuroscience and Neuropharmacology Research
Teikyo University
2021-2025
Tokyo Medical and Dental University
2018-2025
The University of Tokyo
2018-2024
Abstract Previous studies have shown glutamatergic dysfunction and γ-aminobutyric acid (GABA)-ergic in schizophrenia. Animal suggest that N-methyl- d -aspartate receptor (NMDAR) GABA-ergic interact with each other lead to alterations excitatory/inhibitory balance. The NMDAR GABAergic-interneuron functions may be indexed by mismatch negativity (MMN) auditory steady-state gamma-band response (ASSR), respectively. However, no previous tested the hypothesis of an abnormal association between MMN...
The aim of this study is to report the differences in clinicopathological features oral tongue squamous cell carcinoma (OTSCC) and survival between adolescent young adult (AYA) patients elderly find prognosticators. medical records 101 AYA 175 control with OTSCC who underwent surgery were reviewed. Variables related prognosis their associations analyzed. 5-year overall (5y-OS) rates stage I II 94.4% 89.6% (P = .353), respectively, disease-free (5y-DFS) 82.0% 76.6%, respectively .476). 5y-OS...
The interaction between cancer cells and the stroma plays a crucial role in tumor progression metastasis diverse malignancies, including oral cancer. However, mechanism underlying this remains incompletely elucidated. Here, to investigate fibroblasts, which are major cellular components of stroma, we conducted an vitro study by using human squamous cell carcinoma (OSCC) lines normal dermal fibroblasts (NHDFs). results transwell assays revealed that migration invasion 2 OSCC lines, HO1-N-1...
Previous studies have revealed several genes involved in the carcinogenesis of oral cancer. However, detailed mechanisms underlying this process are poorly understood. Previously, we established a database cataloging transcriptional progression profile and identified candidate with continuously increasing or decreasing expression, which specifically promote transition premalignant lesions to invasive carcinomas. In study, using our microarray database, attempted determine significant that...
Primordial odontogenic tumor (POT) is a newly classified, mixed epithelial and mesenchymal tumor, with only 17 reported cases to date. Herein, we report case of POT that occurred in the right maxilla 10-year-old boy reveal unique features comparison those previously reported. Radiologically, lesion presented as well-defined, unilocular radiolucency notable radiopaque foci on periphery. Microscopically, was mainly composed dental papilla-like myxoid fibrous connective tissue, largely...
Abstract Claudins are the major component of tight junctions, which form a primary barrier to paracellular diffusion and maintain cell polarity in normal epithelia endothelia. In cancer cells, claudins play additional roles besides serving as components participate anoikis or invasion. Among claudin family proteins, claudin‐1 has most promising potential, both diagnostically prognostically, many types cancers, including oral, gastric, liver, colon cancers. However, conflicting results have...
Abstract Background Metastasis of infradiaphragmatic tumors to the left supraclavicular lymph node is reported be rare. When metastasis detected in patients with head and neck carcinoma, locating primary cancer remains a difficult time-consuming challenge despite dramatic development screening technologies treatment methods. Case presentation We report three cases malignant tumor diagnosed following an initial finding after surgery for tongue squamous cell carcinoma (follow-up period, range...
Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells, which especially uncommon in the minor glands (MSG). Because its histologic variety, complexity, heterogeneity, it sometimes challenging to make accurate diagnosis. Here, we report literature review EMC MSGs with our experience two cases. Incisional biopsy was suggestive pleomorphic adenoma Case...
Abstract Oral tumors necessitate a dependable computer-assisted pathological diagnosis system considering their rarity and diversity. A content-based image retrieval (CBIR) using deep neural networks has been successfully devised for digital pathology. No CBIR oral pathology investigated because of the lack an extensive database feature extractors tailored to This study uses large constructed from 30 categories compare learning methods as extractors. The highest average area under receiver...
Bone metabolism is strictly regulated, and impaired regulation caused by hormonal imbalances induces systemic bone loss. Local loss tumor invasion into suggested to be induced the generation of cytokines, which affect metabolism, cells. The major cause local losses excess resorption osteoclasts, differentiate from macrophages receptor activator nuclear factor kappa-B ligand (RANKL) or necrosis factor-alpha (TNF-α). We previously found a novel pathway for tumor-induced osteoclastogenesis...
Subjective quality of life is a clinically relevant outcome that strongly associated with the severity clinical symptoms in individuals ultra-high risk for psychosis and patients recent-onset psychotic disorder. Our objective was to examine whether longitudinal changes are disorder.Individuals disorder were recruited same settings at baseline followed up more than 6 months less 5 years later. We assessed five factors using positive negative syndrome scale, World Health Organization...
Abstract Background Primary intraosseous carcinoma (PIOC), NOS is an odontogenic with unknown etiology. Its diagnosis may be used when central jaw cannot categorized as any other type of carcinoma. Further information on this extremely rare tumor needed to improve our understanding and evaluate the classification carcinomas. Case presentation We herein presented two patients PIOC, different clinical histopathological features analyzed gene mutations in these using next-generation sequencing...
Oral tumors necessitate a dependable computer-assisted pathological diagnosis system considering their rarity and diversity. A content-based image retrieval (CBIR) using deep neural networks has been successfully devised for digital pathology. No CBIR oral pathology investigated because of the lack an extensive database feature extractors tailored to
Pleomorphic adenoma (PA) is a benign salivary gland tumor with diverse cytomorphological and architectural features, typically presenting biphasic ductal structures within chondromyxoid matrix. We report unique case of PA where dense lymphoid infiltration disrupted these structures, resulting in duct-like slit lined single layer spindle cells, lacking the pattern. These cells demonstrated myoepithelial nature, confirmed by positive immunostaining for pan-cytokeratin, S100 protein, calponin....
We previously observed a novel osteoclastogenesis system that is induced by oral squamous cell carcinoma (OSCC) cells, which target osteoclast precursor cells (OPC) without upregulation of the master transcriptional factor osteoclastogenesis, NFATc1. Here, we analyzed inflammatory cytokines were preferentially expressed in one osteoclastogenic OSCC lines, namely NEM, compared with subclone had lost its properties. Based on gene expression microarray and protein array analyses, IL-1, IL-6,...
サルコペニアを有する血液透析患者の栄養状態の特徴と食事摂取状況について調査したので報告する. 血液透析患者90人を対象にサルコペニアのスクリーニング, 栄養スクリーニング, 食物摂取頻度調査を実施し, サルコペニアのリスク解析を行った. 対象者のうち22%がサルコペニアに該当し, サルコペニア患者の10～50%に栄養障害のリスクが認められた. 年齢とたんぱく質摂取量不足がサルコペニアの有意なリスク因子であった. サルコペニア群は非サルコペニア群より豆類, 魚介類・肉類, 菓子類・嗜好飲料・砂糖類の摂取量が有意に低かった. サルコペニアの予防には, 十分なたんぱく質摂取が必要であるが, 低栄養に関連するサルコペニアは10～50%であり, 半数以上が低栄養に関係なく筋肉量と筋力が低下していた. 現在透析患者に用いられている栄養評価には, 筋力や身体機能を含めた評価はほとんどない. 今後は運動習慣を含めた調査が必要である.
Abstract Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland tumor, which especially uncommon in the minor glands (MSG). We report literature review of EMC MSGs with our experience two cases. Case 1 75-year-old woman hard elastic mass palate, sized 2.5 × 2 cm without ulceration. Incisional biopsy was suggestive pleomorphic adenoma. Tumor resection performed adequate surgical margin. 44-year-old 1.8 1.6 adenoma or low-grade and intraoral tumor performed. Both have good...
Vascular malformations occur due to errors during vasculogenesis. The incidence of vascular in the jawbone is reportedly rare. A diagnosis often difficult, and treatment requires precise identification location extension tumor. We describe our experience with a case mandibular capillary malformation 12-year-old girl. patient was experiencing right side mental nerve desensitization referred hospital. clinical at first visit mandible Although biopsy performed under general anesthesia, there...
Abstract The liver kinase B1 (LKB1) controls cellular metabolism and cell polarity across species. We previously established a mechanism for negative regulation of transforming growth factor β (TGFβ) signaling by LKB1. impact this in the context epithelial morphogenesis remains unknown. After demonstrating that human mammary tissue expresses robust LKB1 protein levels, whereas invasive breast cancer exhibits significantly reduced we focused on studies three dimensional (3D) acinar organoids....