A5071932953- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Neuroscience and Music Perception
- Mental Health Research Topics
- Neuroscience and Neuropharmacology Research
- Mind wandering and attention
- Mindfulness and Compassion Interventions
- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 and Mental Health
- Ion channel regulation and function
- EEG and Brain-Computer Interfaces
- Digital Mental Health Interventions
- Mental Health and Psychiatry
- Tryptophan and brain disorders
- Psychological and Temporal Perspectives Research
- Family Support in Illness
- Transcranial Magnetic Stimulation Studies
- Technology and Data Analysis
- Reliability and Agreement in Measurement
- Williams Syndrome Research
- Education and Learning Interventions
- Family Caregiving in Mental Illness
- T-cell and Retrovirus Studies
- Veterinary Medicine and Surgery
National Institute of Mental Health
2022-2025
National Center of Neurology and Psychiatry
2022-2025
The University of Tokyo
2019-2024
Japan Society for the Promotion of Science
2022
Waseda University
2015-2021
The auditory mismatch negativity (MMN) is a translatable electroencephalographic biomarker automatically evoked in response to unattended sounds that robustly associated with cognitive and psychosocial disability patients schizophrenia. Although recent animal studies have tried clarify the neural substrates of MMN, nature schizophrenia-related deficits unknown. In this study, we applied novel paradigm developed from translational model carefully deconstruct constituent neurophysiological...
Abstract Aim This study aimed to compare the 12‐item and 36‐item versions of World Health Organization Disability Assessment Schedule (WHODAS) 2.0 using longitudinal data from community mental health outreach service users. Methods Using Tokorozawa City users in Japan, total domain WHODAS‐12 WHODAS‐36 scores were compared. First, we examined score‐change differences by at start services (T1) 1 year later (T2) for each version. Next, compared between two Pearson's correlation, Wilcoxon...
This study aims to examine the psychometric properties of Recovering Quality Life– Japanese version (ReQoL-J) for use in community setting. cross-sectional was conducted among service users mental health facilities. A series confirmatory factor analyses (CFAs) performed. After best-fitting model identified, omega indices, and intraclass correlation (ICC) were calculated evaluate dimensionality reliability. The coefficients between ReQoL-J scores other scales testing construct validity. We...
Abstract Several animal models of schizophrenia and patients with chronic have shown increased spontaneous power gamma oscillations. However, the most robust alterations oscillations in are reduced auditory–oscillatory responses. We hypothesized that early-stage would This study included 77 participants, including 27 ultra-high-risk (UHR) individuals, 19 recent-onset (ROS), 31 healthy controls (HCs). The auditory steady-state response (ASSR) measured as induced during ASSR period were...
In the early intervention in psychosis, ultra-high risk (UHR) criteria have been used to identify individuals who are prone develop psychosis. Although transition rate psychosis at UHR is 10% 30% within several years, some present with poor prognoses even without occurring. Therefore, it important biomarkers for predicting prognosis of UHR, regardless transition. We investigated whether mismatch negativity (MMN) response both duration deviant stimuli (dMMN) and frequency (fMMN) could predict...
The excellence of the brain is its robustness under various types noise and flexibility environments. However, how works still a mystery. critical hypothesis proposes possible mechanism states that criticality plays an important role in healthy brain. Herein, using electroencephalography dataset obtained from patients with psychotic disorders (PDs), ultra-high risk (UHR) individuals controls (HCs), dynamical network analysis, we show HCs remains around state, whereas PD falls into more...
Adolescence is a critical period for psychological difficulties. Auditory mismatch negativity (MMN) and gamma-band auditory steady-state response (ASSR) are representative electrophysiological indices that mature during adolescence. However, the longitudinal association between MMN/ASSR difficulties among adolescents remains unclear. We measured MMN amplitude duration frequency changes ASSR twice in subsample (n = 67, mean age 13.4 16.1 years, respectively) from large-scale population-based...
Individuals with mental illness and their families often undergo recovery process in communities. This study explored the long-term outcome trajectories of individuals who received case management services provided by multidisciplinary outreach teams a community setting. The primary objective this was to determine whether subjective quality life (QoL) related personal were linked those clinical societal outcomes changes service frequency.
Abstract The gamma-band auditory steady-state response (ASSR), primarily generated from the cortex, has received substantial attention as a potential brain marker indicating pathophysiology of schizophrenia. Previous studies have shown reduced ASSR in patients with schizophrenia and demonstrated correlations impaired neurocognition psychosocial functioning. Recent clinical healthy populations suggested that neural substrates may be distributed throughout cortices surrounding especially right...
Mismatch negativity (MMN) is a negative deflection of the auditory event-related potential (ERP) elicited by an abrupt change in sound presented repeatedly. In patients with schizophrenia, MMN consistently reduced, which makes it promising biomarker. A non-human primate (NHP) model based on scalp electroencephalogram (EEG) recordings can provide useful translational tool, given high structural homology prefrontal and cortices between NHPs, such as macaques, humans. However, previous studies,...
Abstract Aim This study aimed to clarify the association between treatment status (untreated or treated) at start of community mental health outreach services and service intensity. Methods retrospective cohort was conducted using Tokorozawa City users' data. Treatment (exposure variable) intensity (outcome variables) were taken from clinical records. Poisson regression linear analyses conducted. The frequency medical social use 12 months after initiation also calculated. approved by...
Subjective quality of life is a clinically relevant outcome that strongly associated with the severity clinical symptoms in individuals ultra-high risk for psychosis and patients recent-onset psychotic disorder. Our objective was to examine whether longitudinal changes are disorder.Individuals disorder were recruited same settings at baseline followed up more than 6 months less 5 years later. We assessed five factors using positive negative syndrome scale, World Health Organization...
Abstract Aim Online classes were implemented in numerous schools during the school closure due to COVID‐19. The present study examined relationship between online national and mental health symptoms after reopening of schools. Methods We conducted a cross‐sectional survey from October 1 November 7, 2020 using an anonymous self‐reported questionnaire evaluate 21 junior senior high Saitama prefecture Japan. Out 5538 students who recruited, 5000 agreed participate. implementation (emotional...
Abstract Background Adverse childhood experiences (ACEs) have lifelong effects on mental health. However, actual situations among users of community comprehensive outreach support with various health problems are unclear. The study comprehensively explored users’ ACEs, associated factors, and when these disclosed during the service process. Methods In this retrospective conducted using records dating October 1, 2015 to April 30, 2023 from in Tokorozawa city, Japan, we collected demographic...