Cyclin D1, an oncogenic G1 cyclin, and YB‐1, a transcription factor involved in cell growth, are both over‐expressed several human cancers. In lung cancer, the functional association between YB‐1 cyclin D1 has never been elucidated. this study, we show is of cancer. Depletion endogenous by siRNA inhibited progression phase down‐regulated protein mRNA levels cancer cells. Forced over‐expression with reporter plasmid increased luciferase activity, ChIP assay results showed bound to promoter....

This study used an augmented reality (AR) head-mounted display to generate three-dimensional (3D) perceived motions involving optic flow and evaluated their effects on aiming motor skill in dart throwing. The were generated by random white spheres moving 3D space. Six motion patterns assessed: random, lateral, radial expansion, contraction, combined diagonal expansion. of these accuracy compared a control condition lacking sphere motions. We observed significant expansion contraction...

For achieving equity of the accessibility to primary healthcare, measuring potential geographical is essential. The provider-to-population ratio most frequently used measure. However, it difficult be in closer region because does not take into consideration people and health services beyond its boundary. In order overcome this problem, we measured access hospital, using both distance measures enhanced two-step floating catchment area (E2SFCA) method. aim study was compare number hospitals...

Abstract We propose an augmented reality (AR)-based training system for basketball free-throws. The optimal shot trajectory free-throws is projected by a head-mounted display according to the shooter’s release point. efficacy of was assessed in novice shooters comparing changes success rates and eye-gaze behavior (quiet eye [QE]) between AR-training control-training groups. rate during AR with did not differ from pre-training rate; however, post-AR training, i.e., after removal trajectory,...

We aimed to assess the prognostic and predictive significance of pretreatment Geriatric Nutritional Risk Index (GNRI) Prognostic (PNI) measurements on advanced non-small cell lung cancer (NSCLC) patients treated with first-line therapy. Patients NSCLC between February 2014 August 2020 were retrospectively analyzed. The optimal cutoff points for GNRI PNI measured receiver operating characteristic (ROC) curve analysis according overall survival (OS). factors progression-free (PFS) OS evaluated...

Today's web is so huge and diverse that it arguably reflects the real world. For this reason, searching a promising approach to find things in This paper presents NEXAS, an extension search engines attempts real-worldentities relevant topic. Its basic idea extract proper names from pages retrieved for A main advantage of users can query any topic learn about real-world entities without dedicated databases In particular, we focus on application finding authoritative people web. practically...

Abstract Background Immune checkpoint inhibitors have potential applications in treating various cancers but are associated with immune-related adverse events, such as inflammation, a wide range of organs; however, allergic inflammation caused by these agents has not been extensively studied. Case presentation A 65-year-old man was diagnosed kidney neuroendocrine carcinoma. Three months after resection surgery, the tumor cells had metastasized to his liver and lymph nodes. Subsequently,...

Y box binding protein 1 ( YB 1) has multiple functions associated with drug resistance, cell proliferation and metastasis through transcriptional translational regulation. Increased expression of is closely related to tumor growth aggressiveness. We showed that levels were decreased replicative premature senescence correlated increased p16 INK 4A suppressor gene. Depletion was in human murine primary cells. Forced mouse embryonic fibroblasts resulted proliferation. Senescence‐associated...

7561 Background: First line treatment by gefitinib for NSCLC patients with EGFR mutations has been validated us (NEJ 002 Study) and WJTOG3405. In these studies, ages less than 75 years were enrolled. Namely, there no data of the first-line elderly mutations. The purpose this study was to investigate efficacy feasibility chemotherapy-naïve or older advanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) Methods: Chemotherapy-naïve age NSCLC, Eastern...

Abstract Background Recently, deaths due to mucormycosis in immunocompromised hosts have increased; however, the clinical and pathological features of are not fully understood, especially view associated high mortality rare incidence immunocompetent patients. Case presentation We described a autopsy case 67-year-old Japanese man with chronic obstructive pulmonary disease who contracted mucormycosis. He had been on any immunosuppressants, his immune functions were intact. Since 3 days prior...

This paper investigates the application of optimal control to experimental flight a Single Coaxial Rotor (SCR) Unmanned Aerial Vehicle (UAV) conducted in indoor facility National Defense Academy (NDA) Japan. The problem is prescribed as minimum-length obstacle avoidance maneuver SCR UAV and it solved using pseudospectral (PS) theory. trajectory computed offline kinematic path-planning then provided real system reference input commands. While only preliminary studies have been at NDA, results...

This study investigates a method for generating obstacle avoidance trajectories by clustering congested obstacles with polygons. The simplifies cluttered obstacles, which would be computationally expensive without clustering, and enclosing them in convex To avoid enclosed polygons, we propose cross product constraints (CPACs). They are of continuous equation using the condition that evaluation points located outside polygons can incorporated into optimization computation to generate...

This paper presents a Jacobi-pseudospectral method with the weights of high-order gauss-lobatto formulae for nonlinear optimal control problem. employs Nth-degree Jacobi polynomial approximations state and variables values these at Jacobi-Gauss-Lobatto (JGL) points as expansion coefficients. The performance index may be approximated using formulae. from this approximation is expressible explicitly in terms polynomial. process yields programming problem (NLP) JGL unknown NLP parameters....

Abstract The known oncogene cyclin D1 (CCND1) participates in progression of the cell cycle from G1 to S-phase. Expression is frequently promoted multiple human cancers including non–small lung cancer (NSCLC). However, a relationship between expression and prognosis NSCLC has not been confirmed. NKX2-1 homeobox transcription factor involved pulmonary development as differentiation-promoting factor. In NSCLC, it acts metastasis suppressor correlates with good prognosis. Here, NKX2-1–binding...

Patients and methods: This cross-sectional study included 1,075 outpatients (men, n=436, 40.6%) at six primary care institutions in Japan. Primary outcomes a salty food preference assessed by using one question daily salt intake, early morning second urine samples. Multivariate analyses determined the relationships between intake two levels. Results: The mean age was 67.6±14.6 years, 594 (55.3%) preferred foods. 12.3±4.0 g per day 11.4±3.7 nonsalt groups, respectively ( P <0.001). A <10...

Cytokine-induced neutrophil chemoattractant (CINC)-1, a counterpart of the human growth-regulated gene product (GRO) interleukin-8 family, has been suggested to play critical roles as mediator inflammatory reactions with infiltration in rats. NF-kappaB speculated be involved production CINC-1, since NF-kappaB-binding domain is important for CINC-1 promoter activity several our reporter assays. In present study, we examined effects an overexpression IkappaBalpha, specific natural inhibitor...

It is unclear whether family medical history influences the willingness to undergo genetic testing. This study aimed determine how affected testing for salt-sensitive hypertension in patients with and without hypertension.Cross-sectional using a self-administered questionnaire.Six primary care clinics hospitals Japan.Consecutive 1705 outpatients aged >20 years, 578 of whom had hypertension.The outcome variable was risk hypertension, secondary variables were age, sex, education level,...