A5056070251- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- CRISPR and Genetic Engineering
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- MicroRNA in disease regulation
- Retinal Development and Disorders
- Child Development and Digital Technology
- Stress Responses and Cortisol
- Autism Spectrum Disorder Research
- Olfactory and Sensory Function Studies
- Neuroendocrine regulation and behavior
UConn Health
2024
Icahn School of Medicine at Mount Sinai
2020-2022
Child Health and Development Institute
2020-2022
Allen Institute for Brain Science
2020-2022
Frontal top-down cortical neurons projecting to sensory regions are well-positioned integrate long-range inputs with local circuitry in frontal cortex implement attentional control of regions. How adolescence contributes the maturation and associated local/long-range input balance, establishment is poorly understood. Here we combine projection-specific electrophysiological rabies-mediated mapping mice uncover as a developmental stage when from anterior cingulate visual highly functionally...
Nicotinic signaling regulates top-down circuit maturation and restores attention deficits in mouse model of fragile X syndrome.
C1QL1 is expressed in a subset of cells the brain and likely has pleiotropic functions, including regulation neuron‐to‐neuron synapses. Research progress on C1QL proteins been slowed by dearth available antibodies. Therefore, we created novel knock‐in mouse line which an HA‐tag inserted into endogenous C1ql1 locus. We examined entire brain, identifying previously unappreciated nuclei expressing C1QL1, presumably neurons. By total numbers, however, large majority C1QL1‐expressing are...
Myelinating oligodendrocytes arise from the stepwise differentiation of oligodendrocyte progenitor cells (OPCs). Approximately 5% all adult brain are OPCs. Why would a mature need such large number OPCs? New myelination is possibly required for higher‐order functions as cognition and learning. Additionally, this pool OPCs represents source new to replace those lost during injury, inflammation, or in diseases multiple sclerosis (MS). How instructed differentiate into poorly understood,...
Abstract Aim Attention is a goal‐directed cognitive process that facilitates the detection of task‐relevant sensory stimuli from dynamic environments. Anterior cingulate cortical area (ACA) known to play key role in attentional behavior, but specific circuits mediating attention remain largely unknown. As ACA modulates processing visual cortex (VIS), we aim test hypothesis frontal top‐down neurons projecting VIS (ACA ) contributes behavior through chemogenetic approach. Methods Adult, male...
Top-down attention is a dynamic cognitive process that facilitates the detection of task-relevant stimuli from our complex sensory environment. A neural mechanism capable deployment under specific task-demand conditions would be crucial to efficiently control attentional processes and improve promote goal-directed performance during fluctuating demand. Previous studies have shown frontal top-down neurons projecting anterior cingulate area (ACA) visual cortex (VIS; ACAVIS) are required for...
Abstract Top-down attention is a dynamic cognitive process that facilitates the detection of task-relevant stimuli from our complex sensory environment. A neural mechanism capable deployment under specific task-demand conditions would be crucial to efficiently control attentional processes and improve promote goal-directed performance during fluctuating demand. Previous studies have shown frontal top-down neurons projecting anterior cingulate area (ACA) visual cortex (VIS; ACA VIS ) are...
Abstract Frontal top-down cortical neurons projecting to sensory regions are well-positioned integrate long-range inputs with local circuitry in frontal cortex implement attentional control of regions. How adolescence contributes the maturation and associated local/long-range input balance, establishment is poorly understood. Here we combine projection-specific electrophysiological rabies-mediated mapping mice uncover as a developmental stage when from anterior cingulate visual highly...