A5044370464- Anesthesia and Pain Management
- Optical Imaging and Spectroscopy Techniques
- Hemodynamic Monitoring and Therapy
- Berry genetics and cultivation research
- Anesthesia and Sedative Agents
- Advanced biosensing and bioanalysis techniques
- Oral Health Pathology and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Gastric Cancer Management and Outcomes
- Salivary Gland Tumors Diagnosis and Treatment
- Nanocomposite Films for Food Packaging
- Pharmacy and Medical Practices
- Nausea and vomiting management
- DNA and Nucleic Acid Chemistry
- Drug Solubulity and Delivery Systems
- Spine and Intervertebral Disc Pathology
- Galectins and Cancer Biology
- Neurological and metabolic disorders
- Cerebrovascular and Carotid Artery Diseases
- Intraoperative Neuromonitoring and Anesthetic Effects
- Diabetes and associated disorders
- Reproductive Biology and Fertility
- Moyamoya disease diagnosis and treatment
- Polysaccharides and Plant Cell Walls
- Prenatal Screening and Diagnostics
Osaka University Hospital
2016-2023
Asahikawa Medical University
2023
Nihon University
2009-2022
Saiseikai Central Hospital
2022
Kitasato University
1990-2021
Sekisui Medical (Japan)
2019
Osaka University
2012-2019
Toho University Ohashi Medical Center
2018-2019
Osaka Dental University
2019
Toho University
2018-2019
Remimazolam, an ultra-short-acting benzodiazepine, has been used for procedural sedation in the United States. We conducted investigator-initiated clinical trial to determine appropriate dose of remimazolam required during gastrointestinal endoscopy Japanese subjects.In this single-center, open-label, uncontrolled, phase II trial, a three-stage cohort investigated initial and additional doses endoscopy. This study was designed with advice from Pharmaceuticals Medical Devices Agency. The were...
We have developed an SNAr reaction-triggered fluorescence probe using a new fluorogenic compound derivatized from 7-aminocoumarin for oligonucleotides detection.
The effect of high and low molecular weight chitosans (HMC; 1000 kDa, LMC; 30 kDa) on oxidative stress hypercholesterolemia was investigated using male 6-week-old Wistar Kyoto rats as a normal model (Normal-rats) spontaneously hypertensive rat/ND mcr-cp (SHP/ND) metabolic syndrome (MS-rats), respectively. In Normal-rats, the ingestion both over 4 week period resulted in significant decrease total body (BW), glucose (Gl), triglyceride (TG), density lipoprotein (LDL) serum creatinine (Cre)...
Therapeutic blocking antibodies against programmed death 1 (PD1) and cytotoxic T-lymphocyte antigen 4 (CTLA4) are applied for advanced cancer therapy, but induce a wide range of immune-related adverse events. In our recent case 52-year-old female doctor suffering from breast having metastasized to the lung liver, it was decided use nivolumab prevent disease progressing after excisional surgeries multiple chemotherapies. One month completing course, fatigue, hypoglycemia hypotension developed...
Enzymatic ligation methods are useful in the diagnostic detection of DNA sequences. Here, we describe investigation nonenzymatic phosphorothioate--iodoacetyl chemical as a method for and identification RNA DNA. The specificity on target is shown to allow discrimination single point mutation with drop yield up 16.1-fold. Although enzymatic has very low activity targets, this reaction efficient targets. speed an achieves 70% 5 s, which equal or better than that ligase-enzyme-mediated target....
Although several studies have demonstrated correlation between white matter hyperintensities (WMH) and impairment of executive functions, the underlying anatomical-functional relationships are not fully understood. The present study sought to investigate correlations volume WMH medial temporal lobe atrophy (MTA) using quantitative magnetic resonance image (MRI) a variety function assessments. A total 91 patients ranging in age from 58 90 years with mild cognitive (MCI) due Alzheimer's...
The antioxidant properties of different low molecular weight (LMW) chitosans (CS1; 22 kDa, CS2; 38 CS3; 52 CS4; 81 kDa) were examined for possible use in extended-release tablets. criteria used the ability to reduce Cu2+, and hydroxyl superoxide radicals N-centered derived from 1,1'-diphenyl-2-picrylhydrazyl, via ESR spectrometry. CS2 showed highest scavenging activity. CS1 CS3, however, much less effective CS4 was not a viable antioxidant. results suggest that could be useful combating...
Acanthosis nigricans (AN) is a hyperpigmented keratotic skin lesion known to be associated with malignant disease and endocrinopathy. We report very rare case of generalized AN Sjögren's syndrome- systemic lupus erythematosus-like features but without type B insulin resistance. Neither internal malignancy nor other endocrinological disorders, including glucose intolerance, were detected during 10-year clinical course benign diffuse papillomatosis extending from the mucosa larynx...
Autoimmune encephalitis (AE) is an immune-mediated characterized by the subacute onset of memory deficits, altered mental status, or psychiatric symptoms. Limbic associated with rheumatoid arthritis (RA) has not been reported yet. A 57-year-old man presented headache, depression, and anorexia 7 months before RA. Brain magnetic resonance imaging showed symmetric parenchymal lesions involving medial temporal lobes. He was diagnosed RA AE, but no autoantibodies to neuronal intracellular...
Aims: Evaluating the accuracy of modified Endoscopic ABC (Endo ABC) classification with an electronic endoscopy narrow band imaging without magnification in diagnosing Helicobacter pylori (H. pylori)-infected gastritis. Methods: A total 576 patients were enrolled and they underwent Endo ABC. They stratified into 5 groups (A to E) based on grades endoscopic findings. H. pylori-infected gastritis status was determined following ways: current defined as active and/or chronic atrophic (CAG) seen...